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    Sanbr SANT and BTB domain regulator of CSR [ Mus musculus (house mouse) ]

    Gene ID: 71675, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sanbrprovided by MGI
    Official Full Name
    SANT and BTB domain regulator of CSRprovided by MGI
    Primary source
    MGI:MGI:1918925
    See related
    Ensembl:ENSMUSG00000042208 AllianceGenome:MGI:1918925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa1841; mKIAA1841; 0610010F05Rik
    Summary
    Enables identical protein binding activity. Involved in isotype switching. Is expressed in central nervous system; ganglia; and sensory organ. Orthologous to human SANBR (SANT and BTB domain regulator of CSR). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 9.0), CNS E14 (RPKM 7.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sanbr in Genome Data Viewer
    Location:
    11 A3.2; 11 14.33 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23514949..23596409, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23564949..23633681, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene STARR-seq mESC enhancer starr_28914 Neighboring gene STARR-seq mESC enhancer starr_28915 Neighboring gene STARR-seq mESC enhancer starr_28916 Neighboring gene STARR-seq mESC enhancer starr_28917 Neighboring gene selenoprotein K, pseudogene 1 Neighboring gene peroxisomal biogenesis factor 13 Neighboring gene pseudouridylate synthase 10 Neighboring gene STARR-seq mESC enhancer starr_28923 Neighboring gene reticuloendotheliosis oncogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination. Zheng S, et al. J Biol Chem, 2021 Jan-Jun. PMID 33831416, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in isotype switching IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isotype switching IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    SANT and BTB domain regulator of class switch recombination

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347242.1 → NP_001334171.1  SANT and BTB domain regulator of class switch recombination isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AI642567, AL672049
      Consensus CDS
      CCDS88137.1
      UniProtKB/Swiss-Prot
      Q68FF0
      Conserved Domains (1) summary
      pfam11822
      Location:1 → 102
      DUF3342; Domain of unknown function (DUF3342)

    2. NM_027860.3 → NP_082136.2  SANT and BTB domain regulator of class switch recombination isoform 1

      See identical proteins and their annotated locations for NP_082136.2

      Status: VALIDATED

      Source sequence(s)
      AK053838, BB522605, BC072622, BC079876, BP759684
      Consensus CDS
      CCDS36119.1
      UniProtKB/Swiss-Prot
      A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
      Related
      ENSMUSP00000136118.2, ENSMUST00000180260.8
      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    RNA

    1. NR_156450.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672049

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23514949..23596409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156994.1 → XP_036012887.1  SANT and BTB domain regulator of class switch recombination isoform X3

      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    2. XM_006514811.5 → XP_006514874.1  SANT and BTB domain regulator of class switch recombination isoform X3

      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    3. XM_036156993.1 → XP_036012886.1  SANT and BTB domain regulator of class switch recombination isoform X2

      UniProtKB/TrEMBL
      M0QWF3
      Related
      ENSMUSP00000137799.2, ENSMUST00000155903.8
      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    4. XM_036156995.1 → XP_036012888.1  SANT and BTB domain regulator of class switch recombination isoform X4

      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    5. XM_017314769.3 → XP_017170258.1  SANT and BTB domain regulator of class switch recombination isoform X4

      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    6. XM_006514808.4 → XP_006514871.1  SANT and BTB domain regulator of class switch recombination isoform X1

      See identical proteins and their annotated locations for XP_006514871.1

      UniProtKB/Swiss-Prot
      A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    7. XM_030246329.1 → XP_030102189.1  SANT and BTB domain regulator of class switch recombination isoform X5

      Related
      ENSMUSP00000090955.5, ENSMUST00000093267.11
      Conserved Domains (1) summary
      pfam11822
      Location:1 → 102
      DUF3342; Domain of unknown function (DUF3342)

    8. XM_030246327.1 → XP_030102187.1  SANT and BTB domain regulator of class switch recombination isoform X1

      UniProtKB/Swiss-Prot
      A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
      Related
      ENSMUSP00000044265.7, ENSMUST00000043356.13
      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    9. XM_011243749.3 → XP_011242051.1  SANT and BTB domain regulator of class switch recombination isoform X1

      See identical proteins and their annotated locations for XP_011242051.1

      UniProtKB/Swiss-Prot
      A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    10. XM_017314768.3 → XP_017170257.1  SANT and BTB domain regulator of class switch recombination isoform X1

      UniProtKB/Swiss-Prot
      A2AF87, A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q68FF0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7
      Conserved Domains (1) summary
      pfam11822
      Location:147 → 248
      DUF3342; Domain of unknown function (DUF3342)

    RNA

    1. XR_004937036.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FF0.2 GenPept UniProtKB/Swiss-Prot:Q68FF0

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