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    Psca prostate stem cell antigen [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680210, updated on 27-Nov-2024

    Summary

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    Gene symbol
    Psca
    Gene description
    prostate stem cell antigen
    See related
    EnsemblRapid:ENSRNOG00000061376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Kidney (RPKM 120.8) and Testes (RPKM 82.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psca in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (108483974..108492098)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (106598203..106603114)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116090189..116091955)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479925 Neighboring gene U6 spliceosomal RNA Neighboring gene activity-regulated cytoskeleton-associated protein Neighboring gene Jrk helix-turn-helix protein Neighboring gene thioesterase superfamily member 6 Neighboring gene secreted Ly6/Plaur domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In utero and lactational exposure of DEHP increases the susceptibility of prostate carcinogenesis in male offspring through PSCA hypomethylation. Xia B, et al. Toxicol Lett, 2018 Aug. PMID 29689378
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypomethylation of PSCA could mediate the effect of di(2-ethylhexyl) phthalate on prostate carcinogenesis in rats.
      Title: In utero and lactational exposure of DEHP increases the susceptibility of prostate carcinogenesis in male offspring through PSCA hypomethylation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    prostate stem cell antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172106.3 → NP_001165577.1  prostate stem cell antigen precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A8F0, D4A6I7
      Related
      ENSRNOP00000099144.1, ENSRNOT00000146932.1
      Conserved Domains (1) summary
      cd00117
      Location:21 → 95
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      108483974..108492098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264246.1 → XP_063120316.1  prostate stem cell antigen isoform X1

    2. XM_039079881.2 → XP_038935809.1  prostate stem cell antigen isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8F0, D4A6I7
      Conserved Domains (1) summary
      cd00117
      Location:21 → 95
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    3. XM_017595109.3 → XP_017450598.1  prostate stem cell antigen isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8F0
    Nucleotide Protein Strain
    Heading Accession and Version

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