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Conserved domains on  [gi|285403261|ref|NP_001165577|]
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prostate stem cell antigen precursor [Rattus norvegicus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 20-96 3.74e-27

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467103  Cd Length: 78  Bit Score: 95.59  E-value: 3.74e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 285403261  20 ALQCYSCTAQVSNRDCLNVQNCTLDQNSCFTSRVRTIGLLTFISKGCSSKCEDDTENYYVGKKNITCCSSDLCNVNG 96
Cdd:cd23573    2 SLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78
 
Name Accession Description Interval E-value
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 20-96 3.74e-27

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 95.59  E-value: 3.74e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 285403261  20 ALQCYSCTAQVSNRDCLNVQNCTLDQNSCFTSRVRTIGLLTFISKGCSSKCEDDTENYYVGKKNITCCSSDLCNVNG 96
Cdd:cd23573    2 SLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-93 3.67e-10

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 52.16  E-value: 3.67e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 285403261   23 CYSCTAQvSNRDCLNVQNCTLDQNSCFTSRVRTIG---LLTFISKGCS-SKC---EDDTENYYVGKKNITCCSSDLCN 93
Cdd:pfam00021   1 CYSCLGV-SNEDCLSEVTCPLSDGQCVTTTLELPEgnlRGTVVSKGCArSSCprlLSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-97 3.75e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 36.74  E-value: 3.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261    21 LQCYSCTaQVSNRDCLNVQNCTLDQNSCFTSRVR--TIGLLTFISKGC--SSKC---EDDTENYYVGKKNITCCSSDLCN 93
Cdd:smart00134   1 LQCYSCT-GNPDSSCSSEEECRSPDDVCLTVVAEviSDSRGSVVYKGCatSPICpgsHGYEINLTIAFLKVSCCQTDLCN 79


                   ....
gi 285403261    94 VNGA 97
Cdd:smart00134  80 AAGP 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 20-96 3.74e-27

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 95.59  E-value: 3.74e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 285403261  20 ALQCYSCTAQVSNRDCLNVQNCTLDQNSCFTSRVRTIGLLTFISKGCSSKCEDDTENYYVGKKNITCCSSDLCNVNG 96
Cdd:cd23573    2 SLQCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNVNG 78
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 19-97 4.02e-16

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 67.74  E-value: 4.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  19 AALQCYSCTAQVSNRDCLNVQNCTLDQNSCFTSRVRT---IGLLTFISKGCSSKCEDDTENYYVGKKNITCCSSDLCNVN 95
Cdd:cd23575    1 HSLKCYTCVSAHSNSDCLTETNCSSSDTYCKTLVASAsggSGSLTTITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNVS 80


                 ..
gi 285403261  96 GA 97
Cdd:cd23575   81 GA 82
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-93 3.67e-10

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 52.16  E-value: 3.67e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 285403261   23 CYSCTAQvSNRDCLNVQNCTLDQNSCFTSRVRTIG---LLTFISKGCS-SKC---EDDTENYYVGKKNITCCSSDLCN 93
Cdd:pfam00021   1 CYSCLGV-SNEDCLSEVTCPLSDGQCVTTTLELPEgnlRGTVVSKGCArSSCprlLSDFINGGIISVSESCCQSDLCN 77
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 20-93 4.89e-09

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 49.27  E-value: 4.89e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 285403261  20 ALQCYSCTAQVSNRDCLNVQNCTLDQNSCFTSRVRTIGLLTF---ISKGCSSKCEDDTENYYVGKKNITCCSSDLCN 93
Cdd:cd23543    2 SLYCYTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGSSSgvrITKKCSPKCPETNVNIGIASVSTSCCQSSLCN 78
TFP_LU_ECD_SLURP1_like cd23560
extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like ...
 21-93 1.50e-07

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467090  Cd Length: 78  Bit Score: 45.51  E-value: 1.50e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 285403261  21 LQCYSCTAQVSNRDCLNVQNCTLDQNSCFTSRVRTIGLLTF-----ISKGCSSKCEDDTENYYVGKKNITCCSSDLCN 93
Cdd:cd23560    1 LRCYTCPEPTDSSLCTTIVNCSPNETACKTTLYSVDSGYPFfgnitVTRGCASECIPSDPDGIGETHPISCCNTDLCN 78
TFP_LU_ECD_LYPD2 cd23620
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar ...
 20-93 1.10e-06

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar proteins; LYPD2 is a lymphocyte antigen-6 family protein. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467140  Cd Length: 79  Bit Score: 43.39  E-value: 1.10e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 285403261  20 ALQCYSCTAQVSNRDCLNVQNCTLDQNSCFTSRVRTIGLLTF-----ISKGCSSKCEDDTENYYVGKKNITCCSSDLCN 93
Cdd:cd23620    1 ALRCYVCPEPTSASDCVTITTCHTNETMCKTTLYSREIVYPFlgdstVTKSCASKCEPSDVDGIGQTRPVSCCNTDLCN 79
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 21-93 1.65e-06

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 42.86  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  21 LQCYSCTAQVSNRDCLN---VQNCTLDQNSCFTSRVRTIGLLTFISKGCSSKCEDD-----TENYYVGKKNITCCSSDLC 92
Cdd:cd00117    1 LKCYQCNSSNDPNCCNSsptLVTCSSPETFCRKIVGKVGGGETLVIRGCATECECGcteccSGTGTSGTTCTSCCDTDLC 80


                 .
gi 285403261  93 N 93
Cdd:cd00117   81 N 81
TFP_LU_ECD_CinHb4_like cd23539
extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; ...
 21-93 3.43e-06

extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; Four distinct globin genes have been identified in the Ciona genome. CinHb4 is encoded by the fourth globin gene. It shows an unusual extension at its N-terminus, which reveals a conserved region with similarity to the extracellular domain (ECD) of the TGF-beta receptor type I/II protein family involved in signal transduction. The functional relevance of these matches is currently unknown. The ECD belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467069  Cd Length: 91  Bit Score: 42.41  E-value: 3.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  21 LQCYSCTAQVSNRDCLN---VQNCTLDQNSCFTSRVRTIGLLTFISKGCSSK--CEDDTENYYVGKKNIT---------- 85
Cdd:cd23539    1 LSCWTCDNASSNEECLAngtLVTCQSNEESCQTEVRRRGGGVYLISKGCKQRqaCENNKKQNFKAAWNPTqcnpespnsv 80

                         90
                 ....*....|.
gi 285403261  86 ---CCSSDLCN 93
Cdd:cd23539   81 crcCCSTDLCN 91
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 21-93 3.55e-05

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 39.37  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  21 LQCYSCTaqvSNRDCLNVQNCTLDQNSCFTSRVRTI---GLLTFISKGCS-SKCEDDTENYYVGKKNI----TCCSSDLC 92
Cdd:cd23556    1 LRCYSCK---SNGDCRVEEVCALGQDLCRTTVMTLWeegEELELVVKGCDvSGKTNASSSYRTGLNINslqeTVCSSDLC 77


                 .
gi 285403261  93 N 93
Cdd:cd23556   78 N 78
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 21-93 3.92e-05

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 38.84  E-value: 3.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 285403261  21 LQCYSCTAQVSNrdCLNVQNCTLDQNSCFTSRVRTIglltfISKGC--SSKCEDDT--ENYYVGKKNITCCSSDLCN 93
Cdd:cd23554    1 LKCYNCPNPTSN--CNTNVTCSSNLDACLIVKAGNR-----IYRQCwkYSDCNFDFisERFGESNFKYRCCQKDLCN 70
TFP_LU_ECD_Cold cd23599
extracellular domain (ECD) found in Drosophila melanogaster protein coiled and similar ...
 21-93 3.07e-04

extracellular domain (ECD) found in Drosophila melanogaster protein coiled and similar proteins; Coiled (Cold) is coded by the Drosophila cold gene that is expressed in a subset of glial cells. It is a member of the Drosophila Ly6 superfamily of extracellular ligands and could behave as a membrane component of the septate junctions (SJ). Cold is essential for tracheal morphogenesis and the organization of the insect SJ in a cell autonomous way. It is also required for organization of the blood-brain-barrier in the Drosophila nervous system. Coiled contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467128  Cd Length: 95  Bit Score: 37.28  E-value: 3.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  21 LQCYSCTAQVSNRD-CLN-VQNCTLDQNSCFTS---------RVRTIGLLtFISKGCSS--KCEDDTE--------NYYV 79
Cdd:cd23599    1 LECYVCKNQEGNKDkCIKtVKQCEPEEDACITYirwgsppywTPRGERQH-YISKGCDTleRCQKQREatepycqrDWYN 79

                         90
                 ....*....|....
gi 285403261  80 GKKNITCCSSDLCN 93
Cdd:cd23599   80 DWECVECCQGDLCN 93
TFP_snake_toxin cd00206
Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, ...
 21-93 3.40e-04

Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheets; it exists as either a monomer or a dimer. The snake toxin domain exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold), which also includes extracellular domain (ECD) found in Ly-6 antigen/uPA receptor-like (LU) superfamily.


Pssm-ID: 467061  Cd Length: 64  Bit Score: 36.55  E-value: 3.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 285403261  21 LQCYSCTaqvsNRDCLNVQNCTLDQNSCFTSRVRTIGLLTFISKGCSSKCEDDTENyyvgkKNITCCSSDLCN 93
Cdd:cd00206    1 LICYNCP----SSTCPTTKTCPPGENLCYKKWWRDGPRGKRIERGCAATCPKPKPG-----EKVKCCSTDKCN 64
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-97 3.75e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 36.74  E-value: 3.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261    21 LQCYSCTaQVSNRDCLNVQNCTLDQNSCFTSRVR--TIGLLTFISKGC--SSKC---EDDTENYYVGKKNITCCSSDLCN 93
Cdd:smart00134   1 LQCYSCT-GNPDSSCSSEEECRSPDDVCLTVVAEviSDSRGSVVYKGCatSPICpgsHGYEINLTIAFLKVSCCQTDLCN 79


                   ....
gi 285403261    94 VNGA 97
Cdd:smart00134  80 AAGP 83
TFP_LU_ECD_Sax cd23600
extracellular domain (ECD) found in Drosophila melanogaster Saxophone and similar proteins; ...
 21-93 5.84e-04

extracellular domain (ECD) found in Drosophila melanogaster Saxophone and similar proteins; Saxophone (Sax) is the Drosophila bone morphogenetic protein (BMP) type I receptor that transmits signal through Mad. It functions as a Dpp (Decapentaplegic) receptor in Drosophila embryos, but that its activity is normally inhibited by the O-linked glycosyltransferase Sxc (Super sex combs). Saxophone is the ortholog of the human activin receptor-like kinase (ALK)-1/2. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467129  Cd Length: 89  Bit Score: 36.13  E-value: 5.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  21 LQCYSCtaqvSNRDCLNVQNCTlDQNSCFTSRVRTIGLLTFISKGCSSKCE-------------DDTENYYVGKKNITCC 87
Cdd:cd23600    4 FKCYSC----EPPDCDPTTVCS-NAIQCWKSRVRDSDGKERVSRGCITEPDqvpftcntkshsgSSKKKPNSGQYSVECC 78


                 ....*.
gi 285403261  88 SSDLCN 93
Cdd:cd23600   79 QGDFCN 84
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 16-93 9.50e-04

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 35.47  E-value: 9.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  16 SPGAALQCYSCTaqvSNRDCLNVQNCTLDQNSCFTSRVrTIGLLTFISKGCSSKCEDDTENYYV--GKKNITCCSSDLCN 93
Cdd:cd23542    1 GPANALQCHVCN---SSSNCTNPVNCEGSERYCKTTTV-VQPSGNLVKKGCAETCPPSTSRQQVgsGISSVTCCQGDLCN 76
TFP_LU_ECD_Ly6M cd23552
extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar ...
 16-93 2.40e-03

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467082  Cd Length: 80  Bit Score: 34.45  E-value: 2.40e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 285403261  16 SPGAALQCYSCtaqVSNRDCLNVQNCTLDQNSCFTSRVRTIGLLTFISKGCSSKCEDDTENYyvGKKNITCCSSDLCN 93
Cdd:cd23552    2 SSAQALKCHEC---KGIEDCYNPTSCNNQSRYCLTTWYTPPGEKTTVTKSCAYTCPDAPESL--ANSKASCCNTDLCN 74
TFP_LU_ECD_SPACA4 cd23574
extracellular domain (ECD) found in sperm acrosome membrane-associated protein 4 (SPACA4); ...
 19-93 5.63e-03

extracellular domain (ECD) found in sperm acrosome membrane-associated protein 4 (SPACA4); SPACA4 (also called SAMP14) is a sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. SPACA4 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467104  Cd Length: 79  Bit Score: 33.50  E-value: 5.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  19 AALQCYSCTAQVSnRDCLNVQNCTLDQNSCFTSRVRTIGLLTFISKGC--SSKCEDDTENYYVG---KKNITCCSSDLCN 93
Cdd:cd23574    1 GAKTCYYCDLTNS-SDCPGIPMICADEEDCYTGRGAALGFPLIINKGCieATRCGKEESVTYMGvtyNLTTYCCEGELCN 79
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 21-97 6.25e-03

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 33.44  E-value: 6.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  21 LQCYSCTAQvSNRDCLNVQNCTLDQNSCFTSRVRTIGLLTFISKGCSSKCEDdTENYYVGKKN-----------ITCCSS 89
Cdd:cd23550    1 LTCHVCEVE-NSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPV-VEVPPPPPKSfvlekpmpflyIKCCRE 78


                 ....*...
gi 285403261  90 DLCNVNGA 97
Cdd:cd23550   79 NLCNEEGP 86
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 21-94 8.52e-03

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 33.15  E-value: 8.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285403261  21 LQCYSCTAQVSNRDCLNVQnCTLDQNSCFTSRVRTIG---LLTFISKGC-------SSKCEDDTENYYVGKKNITCCSSD 90
Cdd:cd23551    2 LKCYQCFKVSSDEDCKPDQ-CAPSEIVCISNEVVLYVgtkVRVLISKRCaprcpntNSRCEWSPGTQVIGSITRTCCSQS 80


                 ....
gi 285403261  91 LCNV 94
Cdd:cd23551   81 LCNR 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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