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    CG40228 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG40228provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0063670
    Locus tag
    Dmel_CG40228
    See related
    AllianceGenome:FB:FBgn0063670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE67573; Dmel\CG40228
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in transcription elongation by RNA polymerase II. Predicted to be part of transcription elongation factor complex. Is expressed in organism. Orthologous to human ELOF1 (elongation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG40228 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (27082091..27083906, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (2188916..2190731, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45177 Neighboring gene long non-coding RNA:CR46252 Neighboring gene long non-coding RNA:CR45181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterochromatic genes in Drosophila: a comparative analysis of two genes. Schulze SR, et al. Genetics, 2006 Jul. PMID 16648646, Free PMC Article
    2. Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster. Syrzycka M, et al. G3 (Bethesda), 2019 May 7. PMID 30948422, Free PMC Article
    3. Adaptation of gene loci to heterochromatin in the course of Drosophila evolution is associated with insulator proteins. Funikov SY, et al. Sci Rep, 2020 Jul 17. PMID 32681087, Free PMC Article
    4. Spt6 enhances the elongation rate of RNA polymerase II in vivo. Ardehali MB, et al. EMBO J, 2009 Apr 22. PMID 19279664, Free PMC Article
    5. The Organization of Pericentromeric Heterochromatin in Polytene Chromosome 3 of the Drosophilamelanogaster Line with the Rif1(1); SuUR(ES) Su(var)3-9(06) Mutations Suppressing Underreplication. Zykova T, et al. Cells, 2021 Oct 20. PMID 34831030, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG40228-PC
    CG40228-PD
    CG40228-PE
    CG40228-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      27082091..27083906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110956.3 → NP_001104426.1  uncharacterized protein Dmel_CG40228, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y556, A8Y557, Q7PL43, Q8MQI6
      UniProtKB/TrEMBL
      L7EEF9
      Conserved Domains (1) summary
      pfam05129
      Location:2 → 79
      Elf1; Transcription elongation factor Elf1 like

    2. NM_001276238.1 → NP_001263167.1  uncharacterized protein Dmel_CG40228, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7ED64
      Conserved Domains (1) summary
      pfam05129
      Location:2 → 74
      Elf1; Transcription elongation factor Elf1 like

    3. NM_001110955.2 → NP_001104425.2  uncharacterized protein Dmel_CG40228, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104425.2

      Status: REVIEWED

      Conserved Domains (1) summary
      cl02038
      Location:6 → 34
      Elf1; Transcription elongation factor Elf1 like

    4. NM_001276237.1 → NP_001263166.1  uncharacterized protein Dmel_CG40228, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y556, A8Y557, Q7PL43, Q8MQI6
      UniProtKB/TrEMBL
      L7EEF9
      Conserved Domains (1) summary
      pfam05129
      Location:2 → 79
      Elf1; Transcription elongation factor Elf1 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L7ED64 L7ED64
    L7EEF9 L7EEF9
    Q8MQI6.1 Q8MQI6

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