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    sgll sugarlethal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sgllprovided by FlyBase
    Official Full Name
    sugarlethalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051472
    Locus tag
    Dmel_CG31472
    See related
    AllianceGenome:FB:FBgn0051472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2649; CG31472; Dmel\CG31472; dPNPO; Sgll
    Summary
    Enables pyridoxamine phosphate oxidase activity. Involved in pyridoxal phosphate biosynthetic process and response to sucrose. Is expressed in adult head and organism. Used to study pyridoxamine 5'-phosphate oxidase deficiency. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sgll in Genome Data Viewer
    Location:
    84E1-84E1; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7810532..7811912)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3636254..3637634)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46127

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes. Chi W, et al. Proc Natl Acad Sci U S A, 2022 Mar 1. PMID 35217610, Free PMC Article
    2. The multifaceted role of vitamin B(6) in cancer: Drosophila as a model system to investigate DNA damage. Contestabile R, et al. Open Biol, 2020 Mar. PMID 32208818, Free PMC Article
    3. Pyridox (am) ine 5'-phosphate oxidase deficiency induces seizures in Drosophila melanogaster. Chi W, et al. Hum Mol Genet, 2019 Sep 15. PMID 31261385, Free PMC Article
    4. A nutritional conditional lethal mutant due to pyridoxine 5'-phosphate oxidase deficiency in Drosophila melanogaster. Chi W, et al. G3 (Bethesda), 2014 Apr 16. PMID 24739647, Free PMC Article
    5. Pyridoxine/pyridoxamine 5'-phosphate oxidase (Sgll/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila. Mascolo E, et al. J Cell Physiol, 2020 Jan. PMID 31506944

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pyridoxine/pyridoxamine 5'-phosphate oxidase (Sgll/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila.
      Title: Pyridoxine/pyridoxamine 5'-phosphate oxidase (Sgll/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pyridoxal phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxal phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vitamin B6 metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sugarlethal
    Names
    CG31472-PA
    CG31472-PB
    pyridoxine 5'-phosphate oxidase
    sgll-PA
    sgll-PB
    NP_731186.2
    NP_731187.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7810532..7811912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169195.4 → NP_731187.1  sugarlethal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731187.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSW3
      Related
      FBpp0081245
      Conserved Domains (3) summary
      TIGR00558
      Location:33 → 237
      pdxH; pyridoxamine-phosphate oxidase
      pfam01243
      Location:50 → 126
      Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
      pfam10590
      Location:182 → 237
      PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region

    2. NM_169194.4 → NP_731186.2  sugarlethal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731186.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS89, Q9VHZ5
      Related
      FBpp0081244
      Conserved Domains (3) summary
      TIGR00558
      Location:42 → 246
      pdxH; pyridoxamine-phosphate oxidase
      pfam01243
      Location:59 → 135
      Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
      pfam10590
      Location:191 → 246
      PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KSW3 Q7KSW3
    Q9VHZ5 Q9VHZ5

    Gene LinkOut

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