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    pla2g12b phospholipase A2, group XIIB [ Danio rerio (zebrafish) ]

    Gene ID: 406739, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pla2g12bprovided by ZNC
    Official Full Name
    phospholipase A2, group XIIBprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2771
    See related
    Ensembl:ENSDARG00000015662 AllianceGenome:ZFIN:ZDB-GENE-040426-2771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56487; zgc:77746; wu:fb26d02; wu:fb99g06; wu:fc91d12; zgc:111897
    Summary
    Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in cholesterol homeostasis and triglyceride homeostasis. Predicted to act upstream of or within arachidonate secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region. Is expressed in caudal fin skeleton and yolk syncytial layer. Orthologous to human PLA2G12B (phospholipase A2 group XIIB). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pla2g12b in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (4671737..4683141)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (4543108..4554563)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487356 Neighboring gene phosphodiesterase 10A Neighboring gene C1D nuclear receptor corepressor Neighboring gene oncoprotein induced transcript 3 Neighboring gene mitochondrial calcium uniporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding. Jawahar J, et al. BMC Genomics, 2022 Mar 22. PMID 35317738, Free PMC Article
    2. The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins. Thierer JH, et al. Nat Commun, 2019 Jul 31. PMID 31366908, Free PMC Article
    3. mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay. Anderson JL, et al. PLoS Genet, 2017 Nov. PMID 29161261, Free PMC Article
    4. Transcriptomics integrated with metabolomics reveals the ameliorating effect of mussel-derived plasmalogens on high-fat diet-induced hyperlipidemia in zebrafish. Feng J, et al. Food Funct, 2023 Apr 24. PMID 36961308
    5. Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acid and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer's disease zebrafish model. Feng J, et al. Food Funct, 2021 Nov 29. PMID 34783821

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111897

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    group XIIB secretory phospholipase A2-like protein
    NP_998595.2
    XP_005156576.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213430.1 → NP_998595.2  group XIIB secretory phospholipase A2-like protein precursor

      See identical proteins and their annotated locations for NP_998595.2

      Status: PROVISIONAL

      Source sequence(s)
      BC052113
      UniProtKB/TrEMBL
      Q6P033
      Related
      ENSDARP00000130123.1, ENSDART00000164617.2
      Conserved Domains (1) summary
      pfam06951
      Location:68 → 231
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      4671737..4683141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156519.5 → XP_005156576.1  group XIIB secretory phospholipase A2-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2B2K0, F1R147
      Related
      ENSDARP00000104679.1, ENSDART00000128494.3
      Conserved Domains (1) summary
      pfam06951
      Location:68 → 235
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
    Nucleotide Protein Strain
    Heading Accession and Version

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