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    ago archipelago [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38516, updated on 17-Dec-2024

    Summary

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    Official Symbol
    agoprovided by FlyBase
    Official Full Name
    archipelagoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041171
    Locus tag
    Dmel_CG15010
    See related
    AllianceGenome:FB:FBgn0041171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ago; anon-WO0118547.345; cdc4; CG15010; Dmel\CG15010; DmFbw7; FBXW3; FBXW7; SCF[Ago]
    Summary
    Enables ubiquitin-specific protease binding activity. Involved in several processes, including DNA endoreduplication; negative regulation of imaginal disc growth; and respiratory system development. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in eye disc morphogenetic furrow; larval central nervous system; muscle cell of A1-7 ventral longitudinal muscle 1; and organism. Used to study developmental delay, hypotonia, and impaired language. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ago in Genome Data Viewer
    Location:
    64A11-64A12; 3-10 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4246343..4254306, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4246343..4254306, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45738 Neighboring gene Sulfide quinone oxidoreductase Neighboring gene pavarotti Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell cycle. Archipelago of destruction. Schwab M, et al. Nature, 2001 Sep 20. PMID 11565017
    2. Myc degradation: dancing with ubiquitin ligases. Amati B. Proc Natl Acad Sci U S A, 2004 Jun 15. PMID 15187232, Free PMC Article
    3. Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome. Stephenson SEM, et al. Am J Hum Genet, 2022 Apr 7. PMID 35395208, Free PMC Article
    4. FUS-induced neurotoxicity is prevented by inhibiting GSK-3β in a Drosophila model of amyotrophic lateral sclerosis. Choi HJ, et al. Hum Mol Genet, 2022 Mar 21. PMID 34605896
    5. SCF-Slimb is critical for Glycogen synthase kinase-3β-mediated suppression of TAF15-induced neurotoxicity in Drosophila. Choi HJ, et al. J Neurochem, 2021 Jun. PMID 32915460

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings indicate that Archipelago (Ago)/FBXW7 controls S6kinase (dS6K) protein levels, but do not impinge on the transcript level.
      Title: A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7.
    2. these findings identify Ago as a required element of a circuit that suppresses the tracheogenic activity of larval muscle cells by antagonizing the Sima-mediated transcriptional response to hypoxia.
      Title: The archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression.
    3. p53-mediated regulation of ectopic neural stem cells (NSC) self-renewal through the Ago/Cyc E axis becomes particularly important when NSC homeostasis is perturbed.
      Title: dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E.
    4. Notch-archipelago-cyclin E link represents a significant new cell cycle regulatory mechanism in the developing eye.
      Title: Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye.
    5. Ago loss induces hyperplasia of some organs but paradoxically reduces the size of the adult eye.
      Title: The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues.
    6. novel function for the ago ubiquitin-ligase in tracheal morphogenesis via Trh and its target breathless, and suggest that ago has distinct functions in mitotic and post-mitotic cells that influence its role in development and disease
      Title: The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system.
    7. archipelago is an important inhibitor of Drosophila Myc in developing tissues, and can regulate Cyclin E levels and Notch activity.
      Title: The Drosophila F box protein archipelago regulates dMyc protein levels in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in branch fusion, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of glial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of exit from mitosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of proteolysis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in trachea development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in trachea development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    archipelago
    Names
    CG15010-PA
    CG15010-PB
    CG15010-PC
    ago-PA
    ago-PB
    ago-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4246343..4254306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079198.3 → NP_523922.1  archipelago, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G6, Q9VZF4
      Related
      FBpp0073101
      Conserved Domains (4) summary
      COG2319
      Location:981 → 1274
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:988 → 1264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:892 → 938
      F-box-like; F-box-like
      sd00039
      Location:998 → 1033
      7WD40; WD40 repeat [structural motif]

    2. NM_168073.2 → NP_728965.1  archipelago, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G6, Q9VZF4
      Related
      FBpp0073102
      Conserved Domains (4) summary
      COG2319
      Location:981 → 1274
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:988 → 1264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:892 → 938
      F-box-like; F-box-like
      sd00039
      Location:998 → 1033
      7WD40; WD40 repeat [structural motif]

    3. NM_168072.2 → NP_728964.1  archipelago, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728964.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G6, Q9VZF4
      Related
      FBpp0073103
      Conserved Domains (4) summary
      COG2319
      Location:981 → 1274
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:988 → 1264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12937
      Location:892 → 938
      F-box-like; F-box-like
      sd00039
      Location:998 → 1033
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZF4.1 Q9VZF4

    Gene LinkOut

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