WD40 repeat [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533  979 WRSRPVRKPKVLKGHDDHViTCLQFS--GNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMS--GNIIISGSTD 1054
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAV-RSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpdGKLLASGSDD 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1055 RTLKVWDMDSGACVHTLQGHTSTVRCMHLH--GSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQY--DGKLIVS 1130
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1131 GAYDYMVKIWHPERQECLHTLQGHTNRVYSLQF--DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQN-- 1206
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgk 343

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17737533 1207 ILVSGNADSTVKVWDITTGQCLQTLSGpnkHHSAVTCLQF--NSRFVVTSSDDGTVKLWDVKT 1267
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTG---HTGAVTSVAFspDGRTLASGSADGTVRLWDLAT 403

WD40 repeat [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533  979 WRSRPVRKPKVLKGHDDHViTCLQFS--GNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMS--GNIIISGSTD 1054
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAV-RSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpdGKLLASGSDD 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1055 RTLKVWDMDSGACVHTLQGHTSTVRCMHLH--GSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQY--DGKLIVS 1130
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1131 GAYDYMVKIWHPERQECLHTLQGHTNRVYSLQF--DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQN-- 1206
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgk 343

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17737533 1207 ILVSGNADSTVKVWDITTGQCLQTLSGpnkHHSAVTCLQF--NSRFVVTSSDDGTVKLWDVKT 1267
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTG---HTGAVTSVAFspDGRTLASGSADGTVRLWDLAT 403

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17737533  875 QVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWK 933
Cdd:cd22133    1 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59

A Receptor for Ubiquitination Targets;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 17737533     895 LPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEK 935
Cdd:smart00256    1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 17737533    1146 ECLHTLQGHTNRVYSLQF--DGLHVVSGSLDTSIRVWD 1181
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40

WD40 repeat [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533  979 WRSRPVRKPKVLKGHDDHViTCLQFS--GNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMS--GNIIISGSTD 1054
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAV-RSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpdGKLLASGSDD 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1055 RTLKVWDMDSGACVHTLQGHTSTVRCMHLH--GSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQY--DGKLIVS 1130
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1131 GAYDYMVKIWHPERQECLHTLQGHTNRVYSLQF--DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQN-- 1206
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgk 343

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17737533 1207 ILVSGNADSTVKVWDITTGQCLQTLSGpnkHHSAVTCLQF--NSRFVVTSSDDGTVKLWDVKT 1267
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTG---HTGAVTSVAFspDGRTLASGSADGTVRLWDLAT 403

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533  988 KVLKGHDDhVITCLQFS--GNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMS--GNIIISGSTDRTLKVWDMD 1063
Cdd:cd00200    3 RTLKGHTG-GVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1064 SGACVHTLQGHTSTVRCMHLHGSK--VVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQY--DGKLIVSGAYDYMVKI 1139
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1140 WHPERQECLHTLQGHTNRVYSLQF--DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQ-SLTSGM-ELRQNILVSGNADS 1215
Cdd:cd00200  162 WDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAfSPDGYLLASGSEDG 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17737533 1216 TVKVWDITTGQCLQTLSGpnkHHSAVTCLQF--NSRFVVTSSDDGTVKLWD 1264
Cdd:cd00200  242 TIRVWDLRTGECVQTLSG---HTNSVTSLAWspDGKRLASGSADGTIRIWD 289

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1067 CVHTLQGHTSTVRCMHLH--GSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQY--DGKLIVSGAYDYMVKIWHP 1142
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1143 ERQECLHTLQGHTNRVYSLQF--DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQN--ILVSGNADSTVK 1218
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDgtFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533 1219 VWDITTGQCLQTLSGpnkHHSAVTCLQF--NSRFVVTSSDDGTVKLWDVKTGDFIRNLValdsgGSGGVVWRIRANDTKL 1296
Cdd:cd00200  161 LWDLRTGKCVATLTG---HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-----GHENGVNSVAFSPDGY 232

                        250
                 ....*....|
gi 17737533 1297 ICAVGSRNGT 1306
Cdd:cd00200  233 LLASGSEDGT 242

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17737533  875 QVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWK 933
Cdd:cd22133    1 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 17737533  891 FISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKE 934
Cdd:cd22148    1 FISLLPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWKA 44

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 17737533  891 FISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKC 936
Cdd:cd22147    1 FLSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 17737533  887 FQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKC 936
Cdd:cd22172    1 EHIDFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLTELDQLWMPKC 50

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 17737533  892 ISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLW 932
Cdd:cd22124    1 ISLLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 17737533    892 ISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWK 933
Cdd:pfam00646    1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 17737533  892 ISLLPRELALF-VLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKC 936
Cdd:cd22109    2 LESLRRRDALFcVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

A Receptor for Ubiquitination Targets;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 17737533     895 LPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEK 935
Cdd:smart00256    1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 17737533  892 ISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKE 934
Cdd:cd22117    1 FDLLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKE 43

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17737533  888 QRDFISLLPRE----LALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKE 934
Cdd:cd22130    1 QRDFISALPAKgldhIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 17737533  892 ISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWK 933
Cdd:cd22123    1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42

protein SPA1-RELATED; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533  1128 IVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQF---DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLT------ 1198
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYssaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICcvqfps 627

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533  1199 -SGMElrqniLVSGNADSTVKVWDITTGQC-LQTLSGpnkHHSAVTCLQF-NSRFVVTSSDDGTVKLWDV 1265
Cdd:PLN00181  628 eSGRS-----LAFGSADHKVYYYDLRNPKLpLCTMIG---HSKTVSYVRFvDSSTLVSSSTDNTLKLWDL 689

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 17737533  892 ISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRK 938
Cdd:cd22084    1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKK 47

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 17737533    1146 ECLHTLQGHTNRVYSLQF--DGLHVVSGSLDTSIRVWD 1181
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17737533  892 ISLLPRELALFVLSYLEPKDLLRAAQ-TCRSWRFLCDDNLLWKEKCRkaqilaepRSDRPKRGRDGNMPpiasPWKAAYM 970
Cdd:cd22168    4 ISDLPEDVLLEILSLVPARDLILSCRlVCSRWRDLVDLPTLWKRKCQ--------REGFILKDWDGPPK----DWKIFYF 71

                 ..
gi 17737533  971 RQ 972
Cdd:cd22168   72 LR 73

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17737533  888 QRDFISLLPRE----LALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKE 934
Cdd:cd22183    1 QRDFITALPAKgldhIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 17737533    1064 SGACVHTLQGHTSTVRCMHLH--GSKVVSGSRDATLRVWD 1101
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40

WD domain, G-beta repeat;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 17737533   1225 GQCLQTLSGpnkHHSAVTCLQF--NSRFVVTSSDDGTVKLWD 1264
Cdd:pfam00400    1 GKLLKTLEG---HTGSVTSLAFspDGKLLASGSDDGTVKVWD 39

WD domain, G-beta repeat;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17737533   1065 GACVHTLQGHTSTVRCMHLH--GSKVVSGSRDATLRVWD 1101
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39

WD domain, G-beta repeat;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17737533   1025 GKCLRTLVGHTGGVWSSQMS--GNIIISGSTDRTLKVWD 1061
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 17737533  895 LPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKC 936
Cdd:cd22137    3 LPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 17737533  895 LPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLW 932
Cdd:cd22156    5 LPEDVLMQILRLLGPKDAAKLCLVCKSWRYLVSDNRLW 42