ths thisbe [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: thsprovided by FlyBase
Official Full Name: thisbeprovided by FlyBase
Primary source: FLYBASE:FBgn0033652
Locus tag: Dmel_CG12443
See related: AllianceGenome:FB:FBgn0033652
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12443; DFGF8-1; Dmel\CG12443; DmThs; fgf8-like; FGF8-like1; Neu4; Ths; THS
Summary: Enables receptor ligand activity. Involved in several processes, including larval development; mesodermal cell fate specification; and mesodermal cell migration. Located in extracellular space. Is expressed in several structures, including epithelium; germ layer; gut section; neurogenic region; and somatic precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 48C2-48C4; 2-65 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11756817..11814424)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7644322..7701929)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

thisbe signaling instructs ensheathing glia wrapping of Drosophila olfactory glomerulus
Title: Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli.
Proliferation of epithelial sheath progenitors, the apical cells, was decreased in both htl and ths mutants, while ectopic expression of the Ths ligand led to these cells' over-proliferation suggesting that FGF signaling supports ovarian muscle sheath formation by controlling apical cell number in the developing gonad.
Title: FGF signaling supports Drosophila fertility by regulating development of ovarian muscle tissues.
Data indicate that Pyramus (Pyr) and Thisbe (Ths) signals play an obligatory role for the survival of the migrating cells.
Title: The FGF8-related signals Pyramus and Thisbe promote pathfinding, substrate adhesion, and survival of migrating longitudinal gut muscle founder cells.
Data show that FGF signaling regulates directional movement of caudal visceral mesoderm cells and that presentation of both FGF ligands, Pyramus and Thisbe, together is most effective at attracting cells.
Title: Synchronous and symmetric migration of Drosophila caudal visceral mesoderm cells requires dual input by two FGF ligands.
Ths and Pyr proteins are secreted from S2 cells as N-terminal fragments as a result of intracellular proteolytic cleavage; the FGF-domain is contained within the secreted ligand portion, and is functions in the embryo when ectopically expressed.
Title: Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs.
pyr and ths single mutants display defects in gastrulation and mesoderm differentiation.
Title: Differential and overlapping functions of two closely related Drosophila FGF8-like growth factors in mesoderm development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thisbe

Names: CG12443-PA; CG12443-PB; ths-PA; ths-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

11756817..11814424

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259339.2 → NP_001246268.1 thisbe, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246268.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7X1

Conserved Domains (1) summary

cl00060
Location:22 → 126

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
NM_136857.4 → NP_610701.2 thisbe, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610701.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6Q7I9

Conserved Domains (1) summary

cl00060
Location:33 → 137

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...