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Conserved domains on  [gi|386767758|ref|NP_001246268|]
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thisbe, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_FGF8-like cd23307
FGF domain, beta-trefoil fold, found in the fibroblast growth factor 8 (FGF8)-like family; The ...
 14-137 5.10e-26

FGF domain, beta-trefoil fold, found in the fibroblast growth factor 8 (FGF8)-like family; The FGF8-like family includes FGF8, FGF17 and FGF18. FGF8, also called androgen-induced growth factor (AIGF), or heparin-binding growth factor 8 (HBGF8), plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation, and cell migration. It is required for normal brain, eye, ear,, and limb development during embryogenesis. It is also required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. It plays a role in neurite outgrowth in hippocampal cells. FGF8 interacts with fibroblast growth factor receptors, FGFR1, FGFR2, FGFR3, and FGFR4. FGF17 plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. It is required for normal brain development. FGF17 interacts with FGFR3 and FGFR4. FGF18, also called zFGF5, plays an important role in the regulation of cell proliferation, cell differentiation, and cell migration. It is required for normal ossification and bone development. It stimulates hepatic and intestinal proliferation. FGF18 interacts FGFR3 and FGFR4. Members in this family contain a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 466993  Cd Length: 127  Bit Score: 103.47  E-value: 5.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767758  14 YVIMSQCaHNKAIHIAaEGTVSVT--DTSQIQNITIVgfpdYLNNEFKIALYAKETRRYLCFNDNWRLVGMRELR--DTC 89
Cdd:cd23307    3 VRLYSRC-SKKFVRIT-GGRVDARgeKGSPYAKLTIE----SVGFSGKVRIRGAKSGRYLCFNKKGKLVAKKNGKkdKRC 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386767758  90 YFNETIVHG-YFVFRSVVDLQRRVGFTHRGKPVGPKKSVNDA--CYMFNKI 137
Cdd:cd23307   77 VFEEELTDGyYTRYRSVKNPSWYLGFNRNGRPLKGSKTRKKKqkCFHFLKR 127
 
Name Accession Description Interval E-value
beta-trefoil_FGF8-like cd23307
FGF domain, beta-trefoil fold, found in the fibroblast growth factor 8 (FGF8)-like family; The ...
 14-137 5.10e-26

FGF domain, beta-trefoil fold, found in the fibroblast growth factor 8 (FGF8)-like family; The FGF8-like family includes FGF8, FGF17 and FGF18. FGF8, also called androgen-induced growth factor (AIGF), or heparin-binding growth factor 8 (HBGF8), plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation, and cell migration. It is required for normal brain, eye, ear,, and limb development during embryogenesis. It is also required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. It plays a role in neurite outgrowth in hippocampal cells. FGF8 interacts with fibroblast growth factor receptors, FGFR1, FGFR2, FGFR3, and FGFR4. FGF17 plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. It is required for normal brain development. FGF17 interacts with FGFR3 and FGFR4. FGF18, also called zFGF5, plays an important role in the regulation of cell proliferation, cell differentiation, and cell migration. It is required for normal ossification and bone development. It stimulates hepatic and intestinal proliferation. FGF18 interacts FGFR3 and FGFR4. Members in this family contain a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466993  Cd Length: 127  Bit Score: 103.47  E-value: 5.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767758  14 YVIMSQCaHNKAIHIAaEGTVSVT--DTSQIQNITIVgfpdYLNNEFKIALYAKETRRYLCFNDNWRLVGMRELR--DTC 89
Cdd:cd23307    3 VRLYSRC-SKKFVRIT-GGRVDARgeKGSPYAKLTIE----SVGFSGKVRIRGAKSGRYLCFNKKGKLVAKKNGKkdKRC 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386767758  90 YFNETIVHG-YFVFRSVVDLQRRVGFTHRGKPVGPKKSVNDA--CYMFNKI 137
Cdd:cd23307   77 VFEEELTDGyYTRYRSVKNPSWYLGFNRNGRPLKGSKTRKKKqkCFHFLKR 127
FGF pfam00167
Fibroblast growth factor; Fibroblast growth factors are a family of proteins involved in ...
 60-126 4.04e-07

Fibroblast growth factor; Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organizms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organizms.


Pssm-ID: 425498  Cd Length: 124  Bit Score: 49.47  E-value: 4.04e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767758   60 IALYAKETRRYLCFNDNWRLVGMRELRDTCYFNETIV-HGYFVFRSVVDLQRR--VGFTHRGKPVGPKKS 126
Cdd:pfam00167  45 VRIKGVESGLYLAMNKKGRLYGSKNFTDECVFKERLLeNNYNTYASAKYSGRGwyVGLNKKGRPKRGSKT 114
FGF smart00442
Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or ...
 59-126 3.70e-04

Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities.


Pssm-ID: 214665  Cd Length: 126  Bit Score: 41.09  E-value: 3.70e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767758    59 KIALYAKETRRYLCFNDNWRLVGMRELRDTCYFNETIV-HGYFVFRSVVDLQR-RVGFTHRGKPVGPKKS 126
Cdd:smart00442  45 VVAIKGVASCRYLCMNKCGKLYGSKNFTEDCVFREEMEeNGYNTYASAKYRKRwYVALNKKGRPRRGQKT 114
 
Name Accession Description Interval E-value
beta-trefoil_FGF8-like cd23307
FGF domain, beta-trefoil fold, found in the fibroblast growth factor 8 (FGF8)-like family; The ...
 14-137 5.10e-26

FGF domain, beta-trefoil fold, found in the fibroblast growth factor 8 (FGF8)-like family; The FGF8-like family includes FGF8, FGF17 and FGF18. FGF8, also called androgen-induced growth factor (AIGF), or heparin-binding growth factor 8 (HBGF8), plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation, and cell migration. It is required for normal brain, eye, ear,, and limb development during embryogenesis. It is also required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. It plays a role in neurite outgrowth in hippocampal cells. FGF8 interacts with fibroblast growth factor receptors, FGFR1, FGFR2, FGFR3, and FGFR4. FGF17 plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. It is required for normal brain development. FGF17 interacts with FGFR3 and FGFR4. FGF18, also called zFGF5, plays an important role in the regulation of cell proliferation, cell differentiation, and cell migration. It is required for normal ossification and bone development. It stimulates hepatic and intestinal proliferation. FGF18 interacts FGFR3 and FGFR4. Members in this family contain a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466993  Cd Length: 127  Bit Score: 103.47  E-value: 5.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767758  14 YVIMSQCaHNKAIHIAaEGTVSVT--DTSQIQNITIVgfpdYLNNEFKIALYAKETRRYLCFNDNWRLVGMRELR--DTC 89
Cdd:cd23307    3 VRLYSRC-SKKFVRIT-GGRVDARgeKGSPYAKLTIE----SVGFSGKVRIRGAKSGRYLCFNKKGKLVAKKNGKkdKRC 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386767758  90 YFNETIVHG-YFVFRSVVDLQRRVGFTHRGKPVGPKKSVNDA--CYMFNKI 137
Cdd:cd23307   77 VFEEELTDGyYTRYRSVKNPSWYLGFNRNGRPLKGSKTRKKKqkCFHFLKR 127
beta-trefoil_FGF cd00058
FGF domain, beta-trefoil fold, found in acidic and basic fibroblast growth factor (FGF) ...
 60-126 4.02e-09

FGF domain, beta-trefoil fold, found in acidic and basic fibroblast growth factor (FGF) superfamily; The FGF superfamily includes FGF1-23 and similar proteins. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. They play essential roles in patterning and differentiation during vertebrate embryogenesis and have neurotrophic activities. FGFs have a high affinity for heparan sulfate proteoglycans and require heparan sulfate to activate one of four cell surface FGF receptors. Upon binding to FGF, the receptors dimerize, and their intracellular tyrosine kinase domains become active. The structure of FGFs is typical of the beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466989  Cd Length: 127  Bit Score: 55.28  E-value: 4.02e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767758  60 IALYAKETRRYLCFNDNWRLVGMRELRDTCYFNETIV-HGYFVFRSVVDLQRR----VGFTHRGKPVGPKKS 126
Cdd:cd00058   44 VRIKGVKTGRYLAMDKNGKLYGTKKPTEDCVFKETLEeNGYNTYSSYKYYHTRkgwyLAIKKNGKPKRGKKT 115
FGF pfam00167
Fibroblast growth factor; Fibroblast growth factors are a family of proteins involved in ...
 60-126 4.04e-07

Fibroblast growth factor; Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organizms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organizms.


Pssm-ID: 425498  Cd Length: 124  Bit Score: 49.47  E-value: 4.04e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767758   60 IALYAKETRRYLCFNDNWRLVGMRELRDTCYFNETIV-HGYFVFRSVVDLQRR--VGFTHRGKPVGPKKS 126
Cdd:pfam00167  45 VRIKGVESGLYLAMNKKGRLYGSKNFTDECVFKERLLeNNYNTYASAKYSGRGwyVGLNKKGRPKRGSKT 114
beta-trefoil_FGF3-like cd23305
FGF domain, beta-trefoil fold, found in the fibroblast growth factor 3 (FGF3)-like family; The ...
 60-120 7.34e-05

FGF domain, beta-trefoil fold, found in the fibroblast growth factor 3 (FGF3)-like family; The FGF3-like family includes FGF3-6. FGF3, also called heparin-binding growth factor 3 (HBGF3), or proto-oncogene Int-2, plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. It is required for normal ear development. FGF3 interacts with fibroblast growth factor receptors, FGFR1 and FGFR2. FGF4, also called heparin secretory-transforming protein 1 (HST-1), or HSTF-1, or heparin-binding growth factor 4 (HBGF4), or transforming protein KS3, plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. It is required for normal limb and cardiac valve development during embryogenesis. It interacts with FGFR1, FGFR2, FGFR3, and FGFR4. FGF5, also called heparin-binding growth factor 5 (HBGF5), or Smag-82, plays an important role in the regulation of cell proliferation and cell differentiation. It is required for normal regulation of the hair growth cycle. It functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. FGF5 interacts with FGFR1 and FGFR2. FGF6, also called heparin secretory-transforming protein 2 (HST-2), or HSTF-2, or heparin-binding growth factor 6 (HBGF6), plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. FGF6 interacts with FGFR1, FGFR2, and FGFR4. Affinity between FGFs and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Members in this family contain a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466991  Cd Length: 127  Bit Score: 43.06  E-value: 7.34e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386767758  60 IALYAKETRRYLCFNDNWRLVGMRELRDTCYFNETIV-HGYFVFRSVVDLQRR----VGFTHRGKP 120
Cdd:cd23305   44 VGIKGVKSGLYLCMNKKGKLYGSKEFTDECKFKERLEeNHYNTYSSALYPRRKrgwyVALSKKGRP 109
FGF smart00442
Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or ...
 59-126 3.70e-04

Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities.


Pssm-ID: 214665  Cd Length: 126  Bit Score: 41.09  E-value: 3.70e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767758    59 KIALYAKETRRYLCFNDNWRLVGMRELRDTCYFNETIV-HGYFVFRSVVDLQR-RVGFTHRGKPVGPKKS 126
Cdd:smart00442  45 VVAIKGVASCRYLCMNKCGKLYGSKNFTEDCVFREEMEeNGYNTYASAKYRKRwYVALNKKGRPRRGQKT 114
beta-trefoil_FGF18 cd23324
FGF domain, beta-trefoil fold, found in fibroblast growth factor 18 (FGF18) and similar ...
 59-136 3.51e-03

FGF domain, beta-trefoil fold, found in fibroblast growth factor 18 (FGF18) and similar proteins; FGF18, also called zFGF5, plays an important role in the regulation of cell proliferation, cell differentiation, and cell migration. It is required for normal ossification and bone development. It stimulates hepatic and intestinal proliferation. FGF18 interacts with fibroblast growth factor receptors, FGFR3 and FGFR4. FGF18 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467010  Cd Length: 126  Bit Score: 38.01  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767758  59 KIALYAKETRRYLCFNDNWRLVGMRE-LRDTCYFNETIV-HGYFVFRSVVDLQRRVGFTHRGKP-VGPKKSVNDACYMFN 135
Cdd:cd23324   44 QVRIKGKETDFYLCMNRKGKLVGKPDgTSKECVFIEKVLeNNYTALMSAKYSGWYVGFTKKGRPrKGPKTRENQQDVHFM 123


                 .
gi 386767758 136 K 136
Cdd:cd23324  124 K 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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