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    Zfp672 zinc finger protein 672 [ Mus musculus (house mouse) ]

    Gene ID: 319475, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp672provided by MGI
    Official Full Name
    zinc finger protein 672provided by MGI
    Primary source
    MGI:MGI:2442105
    See related
    Ensembl:ENSMUSG00000049755 AllianceGenome:MGI:2442105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf672; 4930488P06Rik; 4930511N19Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF672 (zinc finger protein 672). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 6.1), ovary adult (RPKM 5.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp672 in Genome Data Viewer
    Location:
    11 B1.3; 11 36.19 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58205940..58221197, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58315114..58330368, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39827 Neighboring gene nuclear encoded tRNA glutamic acid 10 (anticodon CTC) Neighboring gene STARR-positive B cell enhancer ABC_E2989 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAA) Neighboring gene zinc finger protein 692 Neighboring gene STARR-positive B cell enhancer ABC_E3953 Neighboring gene SH3 binding domain protein 5 like Neighboring gene predicted gene, 33660

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 672

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256516.1 → NP_001243445.1  zinc finger protein 672

      See identical proteins and their annotated locations for NP_001243445.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
      Source sequence(s)
      AK085166, BF730817, CA321162, DV654279
      Consensus CDS
      CCDS24727.1
      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001256517.1 → NP_001243446.1  zinc finger protein 672

      See identical proteins and their annotated locations for NP_001243446.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
      Source sequence(s)
      AK085166, AL845463, BF730817, DV654279
      Consensus CDS
      CCDS24727.1
      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Related
      ENSMUSP00000060088.6, ENSMUST00000057836.12
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001256518.1 → NP_001243447.1  zinc finger protein 672

      See identical proteins and their annotated locations for NP_001243447.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. Variants 1 and 3-7 all encode the functional protein.
      Source sequence(s)
      AK029711, AK085166, AL845463, BB615378, BF730817
      Consensus CDS
      CCDS24727.1
      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Related
      ENSMUSP00000104457.2, ENSMUST00000108829.8
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001256519.1 → NP_001243448.1  zinc finger protein 672

      See identical proteins and their annotated locations for NP_001243448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
      Source sequence(s)
      AK085166, AL845463, BF730817, CV783882, DV654279
      Consensus CDS
      CCDS24727.1
      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001256520.1 → NP_001243449.1  zinc finger protein 672

      See identical proteins and their annotated locations for NP_001243449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
      Source sequence(s)
      AK085166, AL845463, BF730817, CV562361
      Consensus CDS
      CCDS24727.1
      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    6. NM_178761.5 → NP_848876.2  zinc finger protein 672

      See identical proteins and their annotated locations for NP_848876.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1 and 3-7 all encode the functional protein.
      Source sequence(s)
      AK035113, AK085166, BF730817, DV654279
      Consensus CDS
      CCDS24727.1
      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Related
      ENSMUSP00000070567.6, ENSMUST00000064786.12
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_028331.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 5' and 3' end exon structure compared to variant 5. This variant is represented as non-coding because it lacks the entire coding region, as found in all the coding variants.
      Source sequence(s)
      AK019676, BY715308, DV654279
      Related
      ENSMUST00000130217.2

    2. NR_046280.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) contains alternate exon structure in the 5' and 3' regions, compared to variant 5. This variant is represented as non-coding because it lacks the entire coding region, as found in all the coding variants.
      Source sequence(s)
      BG091612, BY715308, DV654279
      Related
      ENSMUST00000135097.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58205940..58221197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156758.1 → XP_036012651.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030246072.1 → XP_030101932.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030246074.2 → XP_030101934.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    4. XM_036156756.1 → XP_036012649.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    5. XM_030246076.2 → XP_030101936.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    6. XM_030246071.2 → XP_030101931.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    7. XM_017314590.2 → XP_017170079.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    8. XM_030246078.2 → XP_030101938.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    9. XM_030246073.2 → XP_030101933.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    10. XM_030246077.2 → XP_030101937.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    11. XM_030246075.2 → XP_030101935.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    12. XM_030246070.2 → XP_030101930.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    13. XM_017314591.2 → XP_017170080.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    14. XM_006533520.4 → XP_006533583.1  zinc finger protein 672 isoform X1

      See identical proteins and their annotated locations for XP_006533583.1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    15. XM_030246069.2 → XP_030101929.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    16. XM_036156757.1 → XP_036012650.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    17. XM_011249069.3 → XP_011247371.1  zinc finger protein 672 isoform X1

      See identical proteins and their annotated locations for XP_011247371.1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    18. XM_036156755.1 → XP_036012648.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q8BIR7, Q99LH4
      Conserved Domains (4) summary
      COG5048
      Location:121 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:105 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 380
      zf-H2C2_2; Zinc-finger double domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183269.1: Suppressed sequence

      Description
      NM_183269.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LH4.1 GenPept UniProtKB/Swiss-Prot:Q99LH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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