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Conserved domains on  [gi|1720366438|ref|XP_030101930|]
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zinc finger protein 672 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-349 2.96e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 121 RQHPPEKPHRCPLCARSFRQSALPFH----LARAHPPEIITVTAPSPSTLYHCTQCPRAFHSSAGLRNHSRIHVVPSLSD 196
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEK 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 197 PGTEAHLCGICGKSFSKSSTLTRHLQ--RHSGE--KPFKCPE--CGKGFLESATLVRHQRTHTGEKPYACSDCGRC--FS 268
Cdd:COG5048   285 GFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSskFS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 269 ESSTLLRHQRSHQ-----GERPHVCA--TCGKGFGQRYDLVVHQRSHTGERP--FPCPQCGRGFTDRSDLTKHLRTHTGE 339
Cdd:COG5048   365 PLLNNEPPQSLQQykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNH 444

                         250
                  ....*....|
gi 1720366438 340 KPYHCELCGK 349
Cdd:COG5048   445 APLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 1.47e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1720366438 356 NLNVHLRNHAGHKPHKCPECGKSFS 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-349 2.96e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 121 RQHPPEKPHRCPLCARSFRQSALPFH----LARAHPPEIITVTAPSPSTLYHCTQCPRAFHSSAGLRNHSRIHVVPSLSD 196
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEK 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 197 PGTEAHLCGICGKSFSKSSTLTRHLQ--RHSGE--KPFKCPE--CGKGFLESATLVRHQRTHTGEKPYACSDCGRC--FS 268
Cdd:COG5048   285 GFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSskFS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 269 ESSTLLRHQRSHQ-----GERPHVCA--TCGKGFGQRYDLVVHQRSHTGERP--FPCPQCGRGFTDRSDLTKHLRTHTGE 339
Cdd:COG5048   365 PLLNNEPPQSLQQykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNH 444

                         250
                  ....*....|
gi 1720366438 340 KPYHCELCGK 349
Cdd:COG5048   445 APLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 3.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720366438 328 DLTKHLRTHTGEKPYHCELCGKRFTC 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1720366438 356 NLNVHLRNHAGHKPHKCPECGKSFS 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 312-361 5.13e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720366438 312 RPFpCPQCGRGFTDRSDLTKHLRTHTgekpYHCELCGKRFTCISNLNVHL 361
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-349 2.96e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 121 RQHPPEKPHRCPLCARSFRQSALPFH----LARAHPPEIITVTAPSPSTLYHCTQCPRAFHSSAGLRNHSRIHVVPSLSD 196
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEK 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 197 PGTEAHLCGICGKSFSKSSTLTRHLQ--RHSGE--KPFKCPE--CGKGFLESATLVRHQRTHTGEKPYACSDCGRC--FS 268
Cdd:COG5048   285 GFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSskFS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 269 ESSTLLRHQRSHQ-----GERPHVCA--TCGKGFGQRYDLVVHQRSHTGERP--FPCPQCGRGFTDRSDLTKHLRTHTGE 339
Cdd:COG5048   365 PLLNNEPPQSLQQykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNH 444

                         250
                  ....*....|
gi 1720366438 340 KPYHCELCGK 349
Cdd:COG5048   445 APLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
11-416 7.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438  11 QERPYSCSVCGKSFQYSAVLLRHERAHGGDKRFCCLECGERCA--RAADLRAHRWTHAGQTLYICSECGQS--FSHSGLL 86
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438  87 DLHLGTHRRRSRTRPCRLCGRRFPHVPALLLHRARQHPPEKPHRCPLCARSFRQSALPFHLARAH------PPEIITVTA 160
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANslskdpSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 161 PSPSTLYHCTQCPRAFHSSAGLRNHSRIHVVPSLSDPGteahLCGICGKSFSKSSTLTRHLQRHSGEKPFKCPECGKGFL 240
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSL----PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 241 ESATLVRHQRTHTGE-------KPYACSDCGRCFSESSTLLRHQRS--HQGE--RPHVC--ATCGKGFGQRYDLVVHQRS 307
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 308 HTGERPFPCPQCGRGFTDRSDLTK----HLRTHTGEKPYH---CELCGKRFTCISNLNV--HLRNHAGHKPH--KCPECG 376
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKkseTLSNSCIRNFKRDSNLslHIITHLSFRPYncKNPPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1720366438 377 KSFSVASKLALHRKTHLGERTAECteCGKFFSHGRSLSQH 416
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 3.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720366438 328 DLTKHLRTHTGEKPYHCELCGKRFTC 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1720366438 356 NLNVHLRNHAGHKPHKCPECGKSFS 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 122-287 1.72e-03

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 40.88  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 122 QHPPEKPhRCPLCARSFRQSALPFHLARAHPPEIITVTAPSPSTLYHCTQCPRAFHSSA-GLrnHSRIHVVPSLSDPGTE 200
Cdd:pfam05110  82 QTPQEKP-DQPFFPDKTSGLPPSFHTSSHSQPMGPPSSSSPSVSSSQSQKKSQARTEPAhGG--HSSSGSQSSQRSQGQS 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 201 AHLCGICGKSFSKSSTLTRHlqrhsgEKPFKCPECGKGFLESATL------------VRHQRTHTGEKPYACSDCGRCFS 268
Cdd:pfam05110 159 RSKGGQESHSSSHHKRQERR------EDLFSCASLSHSLEELSPLlsslsspvkplsPSHSRQHTGSKAQNSSDHHGKEY 232

                         170       180
                  ....*....|....*....|.
gi 1720366438 269 ESSTLLRHQ--RSHQGERPHV 287
Cdd:pfam05110 233 SHSKSPRDSeaGSHGPESPST 253
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-239 1.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.82e-03
                          10        20
                  ....*....|....*....|...
gi 1720366438 217 LTRHLQRHSGEKPFKCPECGKGF 239
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 310-370 2.80e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 310 GERPFPCP--QCGRGFTDRSDLTKH-LRTHTGE------------------KPYHCELCGKRFtciSNLNvHLRNHAGHK 368
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmLHGHQNQklhenpspekmnifsakdKPYRCEVCDKRY---KNLN-GLKYHRKHS 421


                  ..
gi 1720366438 369 PH 370
Cdd:COG5189   422 HD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 3.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.48e-03
                          10        20
                  ....*....|....*....|....
gi 1720366438 245 LVRHQRTHTGEKPYACSDCGRCFS 268
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 312-361 5.13e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720366438 312 RPFpCPQCGRGFTDRSDLTKHLRTHTgekpYHCELCGKRFTCISNLNVHL 361
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-420 5.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 174 RAFHSSAGLRNHSRIHVVPSLSDPGTEAHLCGICGKSFSKSSTLTRHLQRHSgEKPFKCPECGKGFLESATLVRHQRTHt 253
Cdd:COG5048   172 PANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLS- 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 254 geKPYACSDCGRCFSESSTLLRHQRSHQgerphvcatcgkgfgQRYDLVVHQRSHTgerPFPCPQCGRGFTDRSDLTKHL 333
Cdd:COG5048   250 --SSDSSSSASESPRSSLPTASSQSSSP---------------NESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHL 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366438 334 RT--HTGE--KPYHC--ELCGKRFTCISNLNVHLRNHAGHKPHKC----------------------------------- 372
Cdd:COG5048   310 RSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspllnneppqslqqykdlkndkkset 389

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720366438 373 --PECGKSFSVASKLALHRKTHLGERTAEC--TECGKFFSHGRSLSQHQRSH 420
Cdd:COG5048   390 lsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-324 9.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.40e-03
                          10        20
                  ....*....|....*....|....*
gi 1720366438 300 DLVVHQRSHTGERPFPCPQCGRGFT 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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