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    Dph7 diphthamide biosynthesis 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296550, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dph7provided by RGD
    Official Full Name
    diphthamide biosynthesis 7provided by RGD
    Primary source
    RGD:1304868
    See related
    EnsemblRapid:ENSRNOG00000008102 AllianceGenome:RGD:1304868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304868
    Summary
    Predicted to enable diphthine methylesterase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be active in cytoplasm. Orthologous to human DPH7 (diphthamide biosynthesis 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 85.6), Brain (RPKM 63.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dph7 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28168466..28177173)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7770368..7778994)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2170193..2179101)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486057 Neighboring gene arrestin domain containing 1 Neighboring gene zinc finger, MYND-type containing 19 Neighboring gene mitochondrial ribosomal protein L41 Neighboring gene patatin-like phospholipase domain containing 7 Neighboring gene glutathione S-transferase pi 1, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    diphthine methyltransferase
    NP_001381269.1
    NP_001381270.1
    XP_063139524.1
    XP_063139525.1
    XP_063139526.1
    XP_063139527.1
    XP_063139528.1
    XP_063139529.1
    XP_063139530.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394340.1NP_001381269.1  diphthine methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4A1S8
      Related
      ENSRNOP00000040931.5, ENSRNOT00000046898.6
      Conserved Domains (2) summary
      COG2319
      Location:66322
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:90137
      7WD40; WD40 repeat [structural motif]
    2. NM_001394341.1NP_001381270.1  diphthine methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JSZ7
      Conserved Domains (2) summary
      COG2319
      Location:297
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1652
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_172099.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28168466..28177173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283454.1XP_063139524.1  diphthine methyltransferase isoform X1

    2. XM_063283455.1XP_063139525.1  diphthine methyltransferase isoform X2

    3. XM_063283456.1XP_063139526.1  diphthine methyltransferase isoform X3

    4. XM_063283457.1XP_063139527.1  diphthine methyltransferase isoform X3

    5. XM_063283459.1XP_063139529.1  diphthine methyltransferase isoform X4

      UniProtKB/TrEMBL
      A6JSZ7
    6. XM_063283458.1XP_063139528.1  diphthine methyltransferase isoform X4

      UniProtKB/TrEMBL
      A6JSZ7
    7. XM_063283460.1XP_063139530.1  diphthine methyltransferase isoform X4

      UniProtKB/TrEMBL
      A6JSZ7

    RNA

    1. XR_010064600.1 RNA Sequence

    2. XR_010064601.1 RNA Sequence

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