NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2025386908|ref|NP_001381269|]
View 

diphthine methyltransferase isoform 1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
163-299 8.31e-08

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 8.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 163 IISSDSKGQLHLLLLSEGaaqlQLLASWPAHHFEAWIAAFNyWQTELVYSGGDDCLLRGWDTRmLGKPVFTSKRHSMGVC 242
Cdd:COG2319   261 LASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVR 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025386908 243 SIQSSPHReHILATGSYDEHVLLWDTRNVRQPLADVPVQGGVWRLRWHPVHHHLLLA 299
Cdd:COG2319   335 SVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
163-299 8.31e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 8.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 163 IISSDSKGQLHLLLLSEGaaqlQLLASWPAHHFEAWIAAFNyWQTELVYSGGDDCLLRGWDTRmLGKPVFTSKRHSMGVC 242
Cdd:COG2319   261 LASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVR 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025386908 243 SIQSSPHReHILATGSYDEHVLLWDTRNVRQPLADVPVQGGVWRLRWHPVHHHLLLA 299
Cdd:COG2319   335 SVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-340 3.55e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 3.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 197 AWIAAFNYwqTELVYSGGDDCLLRGWDTRMlGKPVFTSKRHSMGVCSIQSSPHReHILATGSYDEHVLLWDTRNvRQPLA 276
Cdd:cd00200    55 RDVAASAD--GTYLASGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVET-GKCLT 129

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025386908 277 DVP-VQGGVWRLRWHPVHHhlLLAACMHNGF-KILNcqkaIEEKQDITVLTSHTMPnslVYGADWS 340
Cdd:cd00200   130 TLRgHTDWVNSVAFSPDGT--FVASSSQDGTiKLWD----LRTGKCVATLTGHTGE---VNSVAFS 186
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 1.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.57e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2025386908  228 GKPVFTSKRHSMGVCSIQSSPHrEHILATGSYDEHVLLWD 267
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
228-267 2.51e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2025386908 228 GKPVFTSKRHSMGVCSIQSSPHrEHILATGSYDEHVLLWD 267
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
163-299 8.31e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 8.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 163 IISSDSKGQLHLLLLSEGaaqlQLLASWPAHHFEAWIAAFNyWQTELVYSGGDDCLLRGWDTRmLGKPVFTSKRHSMGVC 242
Cdd:COG2319   261 LASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVR 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025386908 243 SIQSSPHReHILATGSYDEHVLLWDTRNVRQPLADVPVQGGVWRLRWHPVHHHLLLA 299
Cdd:COG2319   335 SVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
162-340 2.81e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 162 KIISSDSKGQLHLLLLSEGaaqlQLLASWPAHHFEAWIAAFNyWQTELVYSGGDDCLLRGWDTRmLGKPVFTSKRHSMGV 241
Cdd:COG2319   134 TLASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAV 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 242 CSIQSSPHReHILATGSYDEHVLLWDTRNVRQPLADVPVQGGVWRLRWHPvHHHLLLAACMHNGFKILNcqkaIEEKQDI 321
Cdd:COG2319   208 RSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWD----LATGELL 281

                         170
                  ....*....|....*....
gi 2025386908 322 TVLTSHTMPnslVYGADWS 340
Cdd:COG2319   282 RTLTGHSGG---VNSVAFS 297
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-340 3.55e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 3.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 197 AWIAAFNYwqTELVYSGGDDCLLRGWDTRMlGKPVFTSKRHSMGVCSIQSSPHReHILATGSYDEHVLLWDTRNvRQPLA 276
Cdd:cd00200    55 RDVAASAD--GTYLASGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVET-GKCLT 129

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025386908 277 DVP-VQGGVWRLRWHPVHHhlLLAACMHNGF-KILNcqkaIEEKQDITVLTSHTMPnslVYGADWS 340
Cdd:cd00200   130 TLRgHTDWVNSVAFSPDGT--FVASSSQDGTiKLWD----LRTGKCVATLTGHTGE---VNSVAFS 186
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-330 8.34e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 8.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 186 LLASWPAHHFEAWIAAFNYwQTELVYSGGDDCLLRGWDTRMlGKPVFTSKRHSMGVCSIQSSPHREHiLATGSYDEHVLL 265
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2025386908 266 WDTRNVRQPLADVPVQGGVWRLRWHPvHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHTMP 330
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD----VETGKCLTTLRGHTDW 137
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 209-340 1.31e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 209 LVYSGGDDCLLRGWDTRmLGKPVFTSKRHSMGVCSIQSSPHREHILATGSyDEHVLLWDTRNvRQPLADVPV-QGGVWRL 287
Cdd:cd00200   149 FVASSSQDGTIKLWDLR-TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLST-GKCLGTLRGhENGVNSV 225

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2025386908 288 RWHPvhHHLLLAACMHNG-FKILNcqkaIEEKQDITVLTSHTmpnSLVYGADWS 340
Cdd:cd00200   226 AFSP--DGYLLASGSEDGtIRVWD----LRTGECVQTLSGHT---NSVTSLAWS 270
WD40 COG2319
WD40 repeat [General function prediction only];
163-270 3.24e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 163 IISSDSKGQLHLLLLSEGaaqlQLLASWPAHHFEAWIAAFNYWQTELVySGGDDCLLRGWDTRmLGKPVFTSKRHSMGVC 242
Cdd:COG2319   303 LASGSDDGTVRLWDLATG----KLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA-TGELLRTLTGHTGAVT 376

                          90       100
                  ....*....|....*....|....*...
gi 2025386908 243 SIQSSPHrEHILATGSYDEHVLLWDTRN 270
Cdd:COG2319   377 SVAFSPD-GRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-341 9.14e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 9.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 230 PVFTSKRHSMGVCSIQSSPHREHiLATGSYDEHVLLWDTRNVRQPLADVPVQGGVWRLRWHPvHHHLLLAACMHNGFKIL 309
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLW 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2025386908 310 NcqkaIEEKQDITVLTSHTmpnSLVYGADWSW 341
Cdd:cd00200    79 D----LETGECVRTLTGHT---SYVSSVAFSP 103
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 1.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.57e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2025386908  228 GKPVFTSKRHSMGVCSIQSSPHrEHILATGSYDEHVLLWD 267
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-267 1.68e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 153 SVRAREQPLKIISSDSKGQLHLLLLSEGaaqlQLLASWPAHhfEAWI--AAFNyWQTELVYSGGDDCLLRGWDTRMlGKP 230
Cdd:cd00200   182 SVAFSPDGEKLLSSSSDGTIKLWDLSTG----KCLGTLRGH--ENGVnsVAFS-PDGYLLASGSEDGTIRVWDLRT-GEC 253

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2025386908 231 VFTSKRHSMGVCSIQSSPHrEHILATGSYDEHVLLWD 267
Cdd:cd00200   254 VQTLSGHTNSVTSLAWSPD-GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
174-342 9.04e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 9.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 174 LLLLSEGAAQLQLLASWPAHHFEAWIAAFNYWQTELVYSGGDDCLLRGWDTRmlGKPVFTSKRHSMGVCSIQSSPHReHI 253
Cdd:COG2319    16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA--GALLATLLGHTAAVLSVAFSPDG-RL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025386908 254 LATGSYDEHVLLWDTRNVRQPLADVPVQGGVWRLRWHPvHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHTMP-NS 332
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWD----LATGKLLRTLTGHSGAvTS 167

                         170
                  ....*....|
gi 2025386908 333 LVYGADWSWL 342
Cdd:COG2319   168 VAFSPDGKLL 177
WD40 pfam00400
WD domain, G-beta repeat;
228-267 2.51e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2025386908 228 GKPVFTSKRHSMGVCSIQSSPHrEHILATGSYDEHVLLWD 267
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH