Septin4 septin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Septin4provided by RGD
Official Full Name: septin 4provided by RGD
Primary source: RGD:1308781
See related: EnsemblRapid:ENSRNOG00000007367 AllianceGenome:RGD:1308781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sept4; EG3RVC; Pnutl2; EG3-1RVC; hCDCREL-2
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including flagellated sperm motility; hematopoietic stem cell homeostasis; and negative regulation of stem cell proliferation. Predicted to act upstream of or within brain development; sperm capacitation; and sperm mitochondrion organization. Predicted to be located in several cellular components, including axon terminus; perikaryon; and sperm flagellum. Predicted to be part of septin complex. Predicted to be active in several cellular components, including cytoskeleton; dopaminergic synapse; and sperm annulus. Orthologous to human SEPTIN4 (septin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 420.6), Lung (RPKM 367.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (72863969..72888018)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (72366729..72390764)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (74860068..74884196)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

RH144106 (e-PCR)
- UniSTS:233352

RH129619 (e-PCR)
- UniSTS:212916

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sperm mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
involved_in spermatid differentiation	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	ISO Inferred from Sequence Orthology more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm annulus	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm annulus	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: septin-4

Names: CE5B3 beta; apoptosis-related protein in the TGF-beta signaling pathway; arts; bradeion beta; brain protein H5; cell division control-related protein 2; expression gene 3 in rat visual cortex; expression gene 3-1 in rat visual cortex; peanut-like 2; peanut-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011893.2 → NP_001011893.2 septin-4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

Q6XUZ6

Related

ENSRNOP00000072349.1, ENSRNOT00000088581.3

Conserved Domains (1) summary

pfam00735
Location:43 → 315

Septin
NM_001408894.1 → NP_001395823.1 septin-4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

E9PST0, Q6XUZ7

Related

ENSRNOP00000041380.4, ENSRNOT00000044226.6
NM_001408895.1 → NP_001395824.1 septin-4 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

Q5I0G8
NM_001408896.1 → NP_001395825.1 septin-4 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A096MJT3
NM_001414335.1 → NP_001401264.1 septin-4 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

A0A096MJN4

UniProtKB/TrEMBL

Q6XUZ7

Related

ENSRNOP00000068198.1, ENSRNOT00000076026.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

72863969..72888018

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085565.2 → XP_038941493.1 septin-4 isoform X1

Conserved Domains (1) summary

pfam15548
Location:14 → 538

DUF4655; Domain of unknown function (DUF4655)
XM_039085563.2 → XP_038941491.1 septin-4 isoform X8

UniProtKB/TrEMBL

A0A096MJT3

Related

ENSRNOP00000110392.1, ENSRNOT00000165333.1

Conserved Domains (2) summary

pfam00735
Location:664 → 936

Septin

pfam15548
Location:14 → 538

DUF4655; Domain of unknown function (DUF4655)
XM_063268699.1 → XP_063124769.1 septin-4 isoform X7

UniProtKB/TrEMBL

A0A096MJT3
XM_063268696.1 → XP_063124766.1 septin-4 isoform X4
XM_039085566.2 → XP_038941494.1 septin-4 isoform X2

Conserved Domains (1) summary

pfam00735
Location:182 → 454

Septin
XM_017597120.3 → XP_017452609.1 septin-4 isoform X3

UniProtKB/TrEMBL

A0A096MJW0

Related

ENSRNOP00000068282.2, ENSRNOT00000076050.4

Conserved Domains (1) summary

pfam00735
Location:142 → 414

Septin
XM_063268697.1 → XP_063124767.1 septin-4 isoform X5
XM_063268698.1 → XP_063124768.1 septin-4 isoform X6

UniProtKB/TrEMBL

Q6XUZ6