Cdk5rap2 CDK5 regulatory subunit associated protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdk5rap2provided by RGD
Official Full Name: CDK5 regulatory subunit associated protein 2provided by RGD
Primary source: RGD:708451
See related: EnsemblRapid:ENSRNOG00000005788 AllianceGenome:RGD:708451
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including calmodulin binding activity; protein kinase binding activity; and tubulin binding activity. Involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and perinuclear region of cytoplasm. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in microtubule plus-end; mitotic spindle pole; and pericentriolar material. Human ortholog(s) of this gene implicated in Seckel syndrome; microcephaly; and primary autosomal recessive microcephaly 3. Orthologous to human CDK5RAP2 (CDK5 regulatory subunit associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 140.4), Thymus (RPKM 81.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q31

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (88807402..88976005, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (83792282..83961129, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (86387238..86554108, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms
Title: Species-Specific Expression of Full-Length and Alternatively Spliced Variant Forms of CDK5RAP2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH104241 (e-PCR)
- UniSTS:98566

RH130294 (e-PCR)
- UniSTS:213580

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables gamma-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-tubulin binding	IEA Inferred from Electronic Annotation more info
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in centriole replication	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule bundle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule organizing center organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule organizing center organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of centriole replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of centriole replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of gamma-tubulin ring complex	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin ring complex	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IEA Inferred from Electronic Annotation more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitotic spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle pole	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
is_active_in pericentriolar material	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentriolar material	IEA Inferred from Electronic Annotation more info
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CDK5 regulatory subunit-associated protein 2

Names: CDK5 activator-binding protein C48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173134.2 → NP_775157.2 CDK5 regulatory subunit-associated protein 2

Status: PROVISIONAL

Source sequence(s)

CB806103, JAXUCZ010000005

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

UniProtKB/TrEMBL

F1M4B7

Conserved Domains (4) summary

COG0419
Location:106 → 615

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1473 → 1523

MreC; rod shape-determining protein MreC

cl23765
Location:1416 → 1553

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

88807402..88976005 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109347.2 → XP_038965275.1 CDK5 regulatory subunit-associated protein 2 isoform X9

UniProtKB/TrEMBL

A0A3G1T2C5

Related

ENSRNOP00000086004.2, ENSRNOT00000095599.2

Conserved Domains (3) summary

COG0419
Location:105 → 566

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:1339 → 1577

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1
XM_063287220.1 → XP_063143290.1 CDK5 regulatory subunit-associated protein 2 isoform X8
XM_017593184.3 → XP_017448673.1 CDK5 regulatory subunit-associated protein 2 isoform X4

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5
XM_063287224.1 → XP_063143294.1 CDK5 regulatory subunit-associated protein 2 isoform X15

Related

ENSRNOP00000096134.2, ENSRNOT00000118617.2
XM_006238277.5 → XP_006238339.1 CDK5 regulatory subunit-associated protein 2 isoform X6

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

Related

ENSRNOP00000073851.3, ENSRNOT00000083340.3

Conserved Domains (4) summary

pfam00769
Location:147 → 399

ERM; Ezrin/radixin/moesin family

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1439 → 1489

MreC; rod shape-determining protein MreC

cl23765
Location:1382 → 1519

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_063287223.1 → XP_063143293.1 CDK5 regulatory subunit-associated protein 2 isoform X14

Related

ENSRNOP00000106827.1, ENSRNOT00000127377.1
XM_006238276.5 → XP_006238338.1 CDK5 regulatory subunit-associated protein 2 isoform X5

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

Conserved Domains (4) summary

pfam00769
Location:147 → 399

ERM; Ezrin/radixin/moesin family

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1441 → 1491

MreC; rod shape-determining protein MreC

cl23765
Location:1384 → 1521

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_006238279.5 → XP_006238341.1 CDK5 regulatory subunit-associated protein 2 isoform X11

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

Conserved Domains (4) summary

pfam00769
Location:147 → 399

ERM; Ezrin/radixin/moesin family

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1471 → 1521

MreC; rod shape-determining protein MreC

cl23765
Location:1414 → 1551

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_006238274.5 → XP_006238336.1 CDK5 regulatory subunit-associated protein 2 isoform X2

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

Related

ENSRNOP00000086335.1, ENSRNOT00000095333.2

Conserved Domains (4) summary

pfam00769
Location:147 → 399

ERM; Ezrin/radixin/moesin family

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1471 → 1521

MreC; rod shape-determining protein MreC

cl23765
Location:1414 → 1551

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_006238280.5 → XP_006238342.1 CDK5 regulatory subunit-associated protein 2 isoform X13

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

Conserved Domains (4) summary

pfam00769
Location:147 → 399

ERM; Ezrin/radixin/moesin family

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1473 → 1523

MreC; rod shape-determining protein MreC

cl23765
Location:1416 → 1553

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_063287222.1 → XP_063143292.1 CDK5 regulatory subunit-associated protein 2 isoform X12
XM_006238278.5 → XP_006238340.1 CDK5 regulatory subunit-associated protein 2 isoform X10

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

Conserved Domains (4) summary

pfam00769
Location:147 → 399

ERM; Ezrin/radixin/moesin family

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1473 → 1523

MreC; rod shape-determining protein MreC

cl23765
Location:1416 → 1553

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_008763760.4 → XP_008761982.1 CDK5 regulatory subunit-associated protein 2 isoform X3

UniProtKB/TrEMBL

A0A0G2K6K7

Conserved Domains (4) summary

pfam00769
Location:147 → 399

ERM; Ezrin/radixin/moesin family

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1473 → 1523

MreC; rod shape-determining protein MreC

cl23765
Location:1416 → 1553

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_006238273.5 → XP_006238335.1 CDK5 regulatory subunit-associated protein 2 isoform X1

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

Related

ENSRNOP00000007710.8, ENSRNOT00000007710.8

Conserved Domains (4) summary

pfam00769
Location:147 → 399

ERM; Ezrin/radixin/moesin family

pfam07989
Location:61 → 129

Cnn_1N; Centrosomin N-terminal motif 1

cl19252
Location:1473 → 1523

MreC; rod shape-determining protein MreC

cl23765
Location:1416 → 1553

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_039109346.2 → XP_038965274.1 CDK5 regulatory subunit-associated protein 2 isoform X7

UniProtKB/Swiss-Prot

K7QQW0, Q9JLH5

Conserved Domains (2) summary

COG1196
Location:85 → 402

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam07989
Location:12 → 76

Cnn_1N; Centrosomin N-terminal motif 1