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    Crybb1 crystallin, beta B1 [ Mus musculus (house mouse) ]

    Gene ID: 12960, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Crybb1provided by MGI
    Official Full Name
    crystallin, beta B1provided by MGI
    Primary source
    MGI:MGI:104992
    See related
    Ensembl:ENSMUSG00000029343 AllianceGenome:MGI:104992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BB1CRY; 3110006K12Rik
    Summary
    This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. The encoded protein associates with other beta crystallin proteins to form dimers, tetramers and other higher-order complexes. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in genital fat pad adult (RPKM 1.8), ovary adult (RPKM 1.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crybb1 in Genome Data Viewer
    Location:
    5 F; 5 54.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (112403686..112417451)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112254563..112269585)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene myocardial infarction associated transcript (non-protein coding) Neighboring gene VISTA enhancer mm1451 Neighboring gene predicted gene, 52821 Neighboring gene crystallin, beta A4 Neighboring gene STARR-positive B cell enhancer ABC_E6365 Neighboring gene STARR-positive B cell enhancer ABC_E6366 Neighboring gene STARR-positive B cell enhancer ABC_E1685 Neighboring gene predicted gene, 46941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:112714594-112714795 Neighboring gene protein-tyrosine sulfotransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3600

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of the chicken beta B1-crystallin promoter in transgenic mice. Duncan MK, et al. Mech Dev, 1996 Jun. PMID 8817455
    2. The mouse beta B1-crystallin promoter: strict regulation of lens fiber cell specificity. Chen WV, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406268
    3. Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice. Spadaro PA, et al. Biol Psychiatry, 2015 Dec 15. PMID 25792222, Free PMC Article
    4. N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin. Dolinska MB, et al. Biochemistry, 2009 Oct 13. PMID 19746987, Free PMC Article
    5. BetaB1-crystallin: identification of a candidate ciliary body uveitis antigen. Stempel D, et al. Invest Ophthalmol Vis Sci, 2003 Jan. PMID 12506076

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The current study shows for the first time that two highly expressed lens crystallin genes, Cryba4 and Crybb1, can be simultaneously transcribed from adjacent bidirectional promoters and do not show nuclear accumulation.
      Title: Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers.
    2. Removal of the N-terminal extension of beta B1-crystallin has major effects on the physical properties of the protein by increasing the self-association potential and by blocking heteromolecular associations with beta A3-crystallin.
      Title: N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin.
    3. mixed betaB1- and betaA3-crystallins associate predominantly into heterotetramers in equilibrium with heterodimers
      Title: Association properties of betaB1- and betaA3-crystallins: ability to form heterotetramers.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of eye lens ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta-crystallin B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312893.1 → NP_001299822.1  beta-crystallin B1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 - 4 encode the same protein.
      Source sequence(s)
      AK014012, CA452040, CX767595
      Consensus CDS
      CCDS19537.1
      UniProtKB/Swiss-Prot
      Q9WVJ5
      UniProtKB/TrEMBL
      E9PYP8
      Conserved Domains (1) summary
      pfam00030
      Location:148 → 230
      Crystall; Beta/Gamma crystallin

    2. NM_001312894.1 → NP_001299823.1  beta-crystallin B1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 - 4 encodes the same protein.
      Source sequence(s)
      AC123795, AK014012, CA452040, CO046108
      Consensus CDS
      CCDS19537.1
      UniProtKB/Swiss-Prot
      Q9WVJ5
      UniProtKB/TrEMBL
      E9PYP8
      Related
      ENSMUSP00000118399.2, ENSMUST00000131673.8
      Conserved Domains (1) summary
      pfam00030
      Location:148 → 230
      Crystall; Beta/Gamma crystallin

    3. NM_001312895.1 → NP_001299824.1  beta-crystallin B1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 - 4 encode the same protein.
      Source sequence(s)
      AC123795, CX767799, CX767857
      Consensus CDS
      CCDS19537.1
      UniProtKB/Swiss-Prot
      Q9WVJ5
      UniProtKB/TrEMBL
      E9PYP8
      Related
      ENSMUSP00000107994.2, ENSMUST00000112375.2
      Conserved Domains (1) summary
      pfam00030
      Location:148 → 230
      Crystall; Beta/Gamma crystallin

    4. NM_023695.3 → NP_076184.1  beta-crystallin B1

      See identical proteins and their annotated locations for NP_076184.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 - 4 encode the same protein.
      Source sequence(s)
      AK014012, CA452040
      Consensus CDS
      CCDS19537.1
      UniProtKB/Swiss-Prot
      Q9WVJ5
      UniProtKB/TrEMBL
      E9PYP8
      Related
      ENSMUSP00000031286.7, ENSMUST00000031286.13
      Conserved Domains (1) summary
      pfam00030
      Location:148 → 230
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      112403686..112417451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534754.5 → XP_006534817.1  beta-crystallin B1 isoform X1

      UniProtKB/TrEMBL
      E9PYP8
      Conserved Domains (1) summary
      pfam00030
      Location:166 → 248
      Crystall; Beta/Gamma crystallin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVJ5.3 GenPept UniProtKB/Swiss-Prot:Q9WVJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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