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    LOC108699996 E3 ubiquitin-protein ligase HUWE1-like [ Xenopus laevis (African clawed frog) ]

    Gene ID: 108699996, updated on 18-Aug-2023

    Summary

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    Gene symbol
    LOC108699996
    Gene description
    E3 ubiquitin-protein ligase HUWE1-like
    See related
    EnsemblRapid:ENSXLAG00005015187
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
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    Genomic context

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    See LOC108699996 in Genome Data Viewer
    Location:
    chromosome: 8S
    Exon count:
    84
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (37263786..37422991, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (36791826..36878932, complement)

    Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 3 S homeolog Neighboring gene family with sequence similarity 120 member C S homeolog Neighboring gene uncharacterized LOC108699997 Neighboring gene PHD finger protein 8 S homeolog Neighboring gene filamin A S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HUWE1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      37263786..37422991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041574909.1 → XP_041430843.1  E3 ubiquitin-protein ligase HUWE1-like isoform X1

      UniProtKB/TrEMBL
      A0A8J1LMN9, A0A974H5U6
      Conserved Domains (4) summary
      smart00678
      Location:1663 → 1724
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2783 → 3126
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4030 → 4383
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1361 → 1401
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    2. XM_041574913.1 → XP_041430847.1  E3 ubiquitin-protein ligase HUWE1-like isoform X5

      UniProtKB/TrEMBL
      A0A8J1LMU8, A0A974H5U6
      Related
      ENSXLAP00005044959.1, ENSXLAT00005046058.1
      Conserved Domains (4) summary
      smart00678
      Location:1653 → 1714
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2773 → 3116
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4020 → 4373
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1352 → 1391
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    3. XM_041574912.1 → XP_041430846.1  E3 ubiquitin-protein ligase HUWE1-like isoform X4

      UniProtKB/TrEMBL
      A0A8J1LNV6, A0A974H5U6
      Conserved Domains (4) summary
      smart00678
      Location:1654 → 1715
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2774 → 3117
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4021 → 4374
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1352 → 1392
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    4. XM_041574910.1 → XP_041430844.1  E3 ubiquitin-protein ligase HUWE1-like isoform X2

      UniProtKB/TrEMBL
      A0A8J1LNS2, A0A974H5U6
      Conserved Domains (4) summary
      smart00678
      Location:1662 → 1723
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2782 → 3125
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4029 → 4382
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1361 → 1400
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    5. XM_041574916.1 → XP_041430850.1  E3 ubiquitin-protein ligase HUWE1-like isoform X8

      UniProtKB/TrEMBL
      A0A8J1LQ61, A0A974H5U6
      Related
      ENSXLAP00005044988.1, ENSXLAT00005046088.1
      Conserved Domains (4) summary
      smart00678
      Location:1631 → 1692
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2751 → 3094
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:3998 → 4351
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1361 → 1401
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    6. XM_041574914.1 → XP_041430848.1  E3 ubiquitin-protein ligase HUWE1-like isoform X6

      UniProtKB/TrEMBL
      A0A8J1LMP4, A0A974H5U6
      Conserved Domains (4) summary
      smart00678
      Location:1663 → 1724
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2783 → 3126
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4018 → 4371
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1361 → 1401
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    7. XM_041574911.1 → XP_041430845.1  E3 ubiquitin-protein ligase HUWE1-like isoform X3

      UniProtKB/TrEMBL
      A0A8J1LQ56, A0A974H5U6
      Related
      ENSXLAP00005044977.1, ENSXLAT00005046076.1
      Conserved Domains (4) summary
      smart00678
      Location:1663 → 1724
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2783 → 3126
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4028 → 4381
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1361 → 1401
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    8. XM_041574915.1 → XP_041430849.1  E3 ubiquitin-protein ligase HUWE1-like isoform X7

      UniProtKB/TrEMBL
      A0A8J1LNS7, A0A974H5U6
      Conserved Domains (4) summary
      smart00678
      Location:1663 → 1724
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2783 → 3126
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4015 → 4368
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1361 → 1401
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    9. XM_041574907.1 → XP_041430841.1  E3 ubiquitin-protein ligase HUWE1-like isoform X1

      UniProtKB/TrEMBL
      A0A8J1LMN9, A0A974H5U6
      Conserved Domains (4) summary
      smart00678
      Location:1663 → 1724
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2783 → 3126
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4030 → 4383
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1361 → 1401
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    10. XM_041574908.1 → XP_041430842.1  E3 ubiquitin-protein ligase HUWE1-like isoform X1

      UniProtKB/TrEMBL
      A0A8J1LMN9, A0A974H5U6
      Conserved Domains (4) summary
      smart00678
      Location:1663 → 1724
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2783 → 3126
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4030 → 4383
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1361 → 1401
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    11. XM_041574917.1 → XP_041430851.1  E3 ubiquitin-protein ligase HUWE1-like isoform X9

      UniProtKB/TrEMBL
      A0A8J1LNW2, A0A974H5U6
      Conserved Domains (4) summary
      smart00678
      Location:1653 → 1714
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:2773 → 3116
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4008 → 4361
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1352 → 1391
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    Nucleotide Protein Strain
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