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IL22RA2 interleukin 22 receptor subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 116379, updated on 4-Jan-2025

Summary

Official Symbol
IL22RA2provided by HGNC
Official Full Name
interleukin 22 receptor subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:14901
See related
Ensembl:ENSG00000164485 MIM:606648; AllianceGenome:HGNC:14901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
Summary
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL22RA2 in Genome Data Viewer
Location:
6q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (137143820..137173644, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (138332180..138362006, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137464957..137494781, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137311375-137312331 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137322965-137323508 Neighboring gene neuroblastoma highly expressed DDX5 stabilizing lncRNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90349 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90351 Neighboring gene interleukin 20 receptor subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17579 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:137382319-137382457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25128 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:137410449-137410629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25131 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90355 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25133 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90359 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90362 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137492881-137493639 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90370 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:137500946-137502145 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17580 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:137540162-137540892 Neighboring gene interferon gamma receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25139 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137618853-137619479 Neighboring gene uncharacterized LOC105378017

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC150509, MGC150510

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol  
located_in extracellular region  
located_in extracellular space PubMed 
is_active_in plasma membrane  

General protein information

Preferred Names
interleukin-22 receptor subunit alpha-2
Names
cytokine receptor class-II member 10
cytokine receptor family type 2, soluble 1
interleukin 22 receptor, alpha 2
interleukin 22-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052962.3NP_443194.1  interleukin-22 receptor subunit alpha-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI824338, AJ313162, AY040566
    Consensus CDS
    CCDS5182.1
    UniProtKB/Swiss-Prot
    Q08AH7, Q6UWM1, Q969J5, Q96A41, Q96QR0
    Related
    ENSP00000296980.2, ENST00000296980.7
    Conserved Domains (2) summary
    pfam01108
    Location:24146
    Tissue_fac; Tissue factor
    pfam09294
    Location:158263
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  2. NM_181309.2NP_851826.1  interleukin-22 receptor subunit alpha-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_851826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI824338, AJ313161, AY040566
    Consensus CDS
    CCDS5183.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000296979.4, ENST00000349184.9
    Conserved Domains (2) summary
    pfam01108
    Location:23114
    Tissue_fac; Tissue factor
    pfam09294
    Location:126231
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  3. NM_181310.2NP_851827.1  interleukin-22 receptor subunit alpha-2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_851827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the coding region, which leads to a translation frameshift, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI824338, AJ313161, AY040568
    Consensus CDS
    CCDS5184.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000340920.3, ENST00000339602.3
    Conserved Domains (1) summary
    pfam01108
    Location:24114
    Tissue_fac; Tissue factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    137143820..137173644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    138332180..138362006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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