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IL17RA interleukin 17 receptor A [ Homo sapiens (human) ]

Gene ID: 23765, updated on 27-Nov-2024

Summary

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Official Symbol
IL17RAprovided by HGNC
Official Full Name
interleukin 17 receptor Aprovided by HGNC
Primary source
HGNC:HGNC:5985
See related
Ensembl:ENSG00000177663 MIM:605461; AllianceGenome:HGNC:5985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
Summary
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 11.6), appendix (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

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See IL17RA in Genome Data Viewer
Location:
22q11.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (17085000..17115693)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (17761784..17792571)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (17565890..17596583)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 9 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18610 Neighboring gene cat eye syndrome chromosome region, candidate 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62188 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:17538919-17539419 Neighboring gene Sharpr-MPRA regulatory region 13635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13428 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62270 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13430 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13432 Neighboring gene ribosomal protein L31 pseudogene 62 Neighboring gene MPRA-validated peak4440 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18611 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:17587847-17589046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:17602677-17603208 Neighboring gene transmembrane protein 121B Neighboring gene long intergenic non-protein coding RNA 1664

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The promoter SNP, but not the alternative splicing SNP, is linked to multiple sclerosis among Jordanian patients. Ibayyan L, et al. J Mol Neurosci, 2014 Apr. PMID 24166352
  2. Interleukin 17 receptor A haplotype analysis in chronic spontaneous urticaria: A preliminary study. Nada H, et al. J Cosmet Dermatol, 2021 Apr. PMID 32969586
  3. IL17RA in early-onset coronary artery disease: Total leukocyte transcript analysis and promoter polymorphism (rs4819554) association. Coto E, et al. Cytokine, 2020 Dec. PMID 32950026
  4. Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop. Draberova H, et al. EMBO J, 2020 Sep 1. PMID 32696476, Free PMC Article
  5. IL17RA variations showed no associations with post-bronchiolitis asthma or lung function. Lauhkonen E, et al. Pediatr Int, 2021 Feb. PMID 32654355

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased interleukin-17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice.
    Title: Decreased interleukin-17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice.
  2. Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis.
    Title: Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis.
  3. Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer.
    Title: Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer.
  4. Association between IL-17F, IL-17RA Gene Polymorphisms and Response to Biological Drugs in Psoriasis and Beyond.
    Title: Association between IL-17F, IL-17RA Gene Polymorphisms and Response to Biological Drugs in Psoriasis and Beyond.
  5. Immunogenic Cell Death Associated Molecular Patterns and the Dual Role of IL17RA in Interstitial Cystitis/Bladder Pain Syndrome.
    Title: Immunogenic Cell Death Associated Molecular Patterns and the Dual Role of IL17RA in Interstitial Cystitis/Bladder Pain Syndrome.
  6. IL17A and IL17RA gene polymorphisms in Fanconi anemia.
    Title: IL17A and IL17RA gene polymorphisms in Fanconi anemia.
  7. lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway.
    Title: lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway.
  8. Evaluation of interleukin-17 receptor (IL-17RA) gene expression in PBMCs of patients with premature coronary artery disease.
    Title: Evaluation of interleukin-17 receptor (IL-17RA) gene expression in PBMCs of patients with premature coronary artery disease.
  9. Serum IL-17A concentration and a IL17RA single nucleotide polymorphism contribute to the risk of autoimmune type 1 diabetes.
    Title: Serum IL-17A concentration and a IL17RA single nucleotide polymorphism contribute to the risk of autoimmune type 1 diabetes.
  10. Polymorphisms within Genes Coding for IL-17A and F and Their Receptor as Clinical Hallmarks in Ankylosing Spondylitis.
    Title: Polymorphisms within Genes Coding for IL-17A and F and Their Receptor as Clinical Hallmarks in Ankylosing Spondylitis.
Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency 51
MedGen: C4310803 OMIM: 613953 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: CECR7

Homology

Clone Names

  • FLJ32274, FLJ36453, MGC10262

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-17 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-17 receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T-helper 17 type immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in granulocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-17-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interleukin-17A-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-23 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-17 receptor A
Names
IL-17 receptor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028257.1 RefSeqGene

    Range
    4999..35734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_355

mRNA and Protein(s)

  1. NM_001289905.2 → NP_001276834.1  interleukin-17 receptor A isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes a soluble isoform, isoform 2 which is shorter and lacks a transmembrane region, when compared to isoform 1.
    Source sequence(s)
    AC006946, BX368715, BX410574
    Consensus CDS
    CCDS77645.1
    UniProtKB/Swiss-Prot
    Q96F46
    Related
    ENSP00000479970.1, ENST00000612619.2
    Conserved Domains (3) summary
    pfam08357
    Location:344 → 502
    SEFIR; SEFIR domain
    pfam16556
    Location:48 → 198
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:199 → 303
    IL17R_fnIII_D2; Interleukin 17 receptor D

  2. NM_014339.7 → NP_055154.3  interleukin-17 receptor A isoform 1 precursor

    See identical proteins and their annotated locations for NP_055154.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC006946, BU585070, CB044543, U58917
    Consensus CDS
    CCDS13739.1
    UniProtKB/Swiss-Prot
    O43844, Q20WK1, Q96F46
    Related
    ENSP00000320936.6, ENST00000319363.11
    Conserved Domains (3) summary
    pfam08357
    Location:378 → 536
    SEFIR; SEFIR domain
    pfam16556
    Location:48 → 198
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:199 → 303
    IL17R_fnIII_D2; Interleukin 17 receptor D

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    17085000..17115693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    17761784..17792571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96F46.2 GenPept UniProtKB/Swiss-Prot:Q96F46

Gene LinkOut

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