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    Ak1 adenylate kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24183, updated on 4-Jan-2025

    Summary

    Symbol
    Ak1provided by RGD
    Full Name
    adenylate kinase 1provided by RGD
    Primary source
    RGD:2076
    See related
    EnsemblRapid:ENSRNOG00000049056 AllianceGenome:RGD:2076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ak 1
    Summary
    Enables adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including nervous system development; nucleobase-containing small molecule metabolic process; and positive regulation of neuron maturation. Located in perinuclear region of cytoplasm and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 1320.1), Heart (RPKM 466.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Ak1 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36310113..36320760)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15912431..15923045)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11652143..11659135)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene endoglin Neighboring gene folylpolyglutamate synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC108678

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (deoxy)adenylate kinase activity  
    enables ATP binding  
    enables adenylate kinase activity  
    enables adenylate kinase activity PubMed 
    enables adenylate kinase activity  
    enables adenylate kinase activity  
    enables nucleoside diphosphate kinase activity  
    enables nucleoside diphosphate kinase activity  
    enables nucleoside diphosphate kinase activity  
    contributes_to phosphotransferase activity, phosphate group as acceptor PubMed 
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process PubMed 
    involved_in ADP biosynthetic process  
    involved_in AMP metabolic process PubMed 
    involved_in AMP metabolic process  
    involved_in ATP metabolic process  
    involved_in adenine metabolic process PubMed 
    involved_in cerebellum development PubMed 
    involved_in inosine biosynthetic process PubMed 
    involved_in muscle organ development PubMed 
    involved_in neuron differentiation PubMed 
    involved_in nucleoside monophosphate phosphorylation  
    involved_in nucleoside triphosphate biosynthetic process  
    involved_in olfactory bulb development PubMed 
    involved_in positive regulation of D-glucose transmembrane transport PubMed 
    involved_in positive regulation of neuron maturation PubMed 
    involved_in response to activity PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in outer dense fiber  
    located_in outer dense fiber  
    located_in perinuclear region of cytoplasm PubMed 
    located_in sarcomere PubMed 
    located_in sperm flagellum  

    General protein information

    Preferred Names
    adenylate kinase isoenzyme 1
    Names
    ATP-AMP transphosphorylase 1
    ATP:AMP phosphotransferase
    adenylate kinase isoenzyme 1-like
    adenylate monophosphate kinase
    myokinase
    NP_077325.2
    XP_038960159.1
    XP_038960160.1
    XP_038960161.1
    XP_038960162.1
    XP_038960163.1
    XP_063139143.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024349.4NP_077325.2  adenylate kinase isoenzyme 1

      See identical proteins and their annotated locations for NP_077325.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P39069, Q5EBC5, Q9JJN3
      UniProtKB/TrEMBL
      A6JU72, A6JU73
      Related
      ENSRNOP00000067175.4, ENSRNOT00000073840.4
      Conserved Domains (1) summary
      TIGR01360
      Location:6193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36310113..36320760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104232.2XP_038960160.1  adenylate kinase isoenzyme 1 isoform X2

      UniProtKB/Swiss-Prot
      P39069, Q5EBC5, Q9JJN3
      UniProtKB/TrEMBL
      A6JU72, A6JU73
      Conserved Domains (1) summary
      TIGR01360
      Location:6193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    2. XM_039104234.2XP_038960162.1  adenylate kinase isoenzyme 1 isoform X2

      UniProtKB/Swiss-Prot
      P39069, Q5EBC5, Q9JJN3
      UniProtKB/TrEMBL
      A6JU72, A6JU73
      Conserved Domains (1) summary
      TIGR01360
      Location:6193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    3. XM_039104233.2XP_038960161.1  adenylate kinase isoenzyme 1 isoform X2

      UniProtKB/Swiss-Prot
      P39069, Q5EBC5, Q9JJN3
      UniProtKB/TrEMBL
      A6JU72, A6JU73
      Related
      ENSRNOP00000074303.2, ENSRNOT00000091048.3
      Conserved Domains (1) summary
      TIGR01360
      Location:6193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    4. XM_063283073.1XP_063139143.1  adenylate kinase isoenzyme 1 isoform X2

      UniProtKB/Swiss-Prot
      P39069, Q5EBC5, Q9JJN3
      UniProtKB/TrEMBL
      A6JU72, A6JU73
    5. XM_039104235.2XP_038960163.1  adenylate kinase isoenzyme 1 isoform X2

      UniProtKB/Swiss-Prot
      P39069, Q5EBC5, Q9JJN3
      UniProtKB/TrEMBL
      A6JU72, A6JU73
      Conserved Domains (1) summary
      TIGR01360
      Location:6193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    6. XM_039104231.2XP_038960159.1  adenylate kinase isoenzyme 1 isoform X1

      UniProtKB/TrEMBL
      A6JU72, A6JU74, M0RC66
      Related
      ENSRNOP00000109041.1, ENSRNOT00000152600.1
      Conserved Domains (1) summary
      TIGR01360
      Location:22209
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
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