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Conserved domains on  [gi|1958759759|ref|XP_038960160|]
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adenylate kinase isoenzyme 1 isoform X2 [Rattus norvegicus]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492279)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 8.16e-129

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 359.51  E-value: 8.16e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   6 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVD 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  86 SSNGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1958759759 166 KRGIVRKVNAEGSVDTVFSQVCTYLDSL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 8.16e-129

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 359.51  E-value: 8.16e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   6 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVD 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  86 SSNGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1958759759 166 KRGIVRKVNAEGSVDTVFSQVCTYLDSL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 10-182 2.29e-75

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 224.81  E-value: 2.29e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSNG 89
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  90 FLIDGYPREVKQGEEFERKI---AQPTLLLYVDAGPETMTQRLLKRGET-------------------SGRVDDNEETIK 147
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958759759 148 KRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTV 182
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
13-167 1.10e-71

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 214.87  E-value: 1.10e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  13 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlAKVDSSNGFLI 92
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  93 DGYPREVKQGEEFERK---IAQPTLLLYVDAGPETMTQRLLKRGET---------------------------SGRVDDN 142
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 1958759759 143 EETIKKRLETYYKATEPVISFYDKR 167
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 9-190 1.18e-64

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 198.04  E-value: 1.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSN 88
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  89 GFLIDGYPREVKQGEEFERKIAQP----TLLLYVDAGPETMTQRLLKR---------------------------GETSG 137
Cdd:COG0563    80 GFILDGFPRTVAQAEALDELLAELgiklDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958759759 138 RVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYL 190
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 9-193 1.99e-64

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 197.68  E-value: 1.99e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSN 88
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  89 GFLIDGYPREVKQGEEFERKIAQPTL----LLYVDAGPETMTQRLLKR---------------------------GETSG 137
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDEMLKELGIkldaVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759759 138 RVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLDSL 193
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 8.16e-129

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 359.51  E-value: 8.16e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   6 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVD 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  86 SSNGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1958759759 166 KRGIVRKVNAEGSVDTVFSQVCTYLDSL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 10-182 2.29e-75

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 224.81  E-value: 2.29e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSNG 89
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  90 FLIDGYPREVKQGEEFERKI---AQPTLLLYVDAGPETMTQRLLKRGET-------------------SGRVDDNEETIK 147
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1958759759 148 KRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTV 182
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
13-167 1.10e-71

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 214.87  E-value: 1.10e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  13 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlAKVDSSNGFLI 92
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  93 DGYPREVKQGEEFERK---IAQPTLLLYVDAGPETMTQRLLKRGET---------------------------SGRVDDN 142
Cdd:pfam00406  80 DGFPRTVPQAEALEELlerGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 1958759759 143 EETIKKRLETYYKATEPVISFYDKR 167
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 10-186 1.60e-70

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 212.23  E-value: 1.60e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVS-SGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKvDSSN 88
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQED-GSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  89 GFLIDGYPREVKQGEEFERKI---AQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 165
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMdnkVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 1958759759 166 KRGIVRKVNAEGSVDTVFSQV 186
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 9-190 1.18e-64

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 198.04  E-value: 1.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSN 88
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  89 GFLIDGYPREVKQGEEFERKIAQP----TLLLYVDAGPETMTQRLLKR---------------------------GETSG 137
Cdd:COG0563    80 GFILDGFPRTVAQAEALDELLAELgiklDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958759759 138 RVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYL 190
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 9-193 1.99e-64

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 197.68  E-value: 1.99e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSN 88
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  89 GFLIDGYPREVKQGEEFERKIAQPTL----LLYVDAGPETMTQRLLKR---------------------------GETSG 137
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDEMLKELGIkldaVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759759 138 RVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLDSL 193
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 9-191 8.79e-56

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 175.50  E-value: 8.79e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVDSSN 88
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  89 GFLIDGYPREVKQGEEFERKIA-QPTLLLYVDAGPETMTQRLLKRG--ETSGRV-------------------------D 140
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLEePIDAVIELDVPDEELVERLSGRRicPSCGRVyhlkfnppkvpgcddctgellvqreD 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958759759 141 DNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLD 191
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
PLN02200 PLN02200
adenylate kinase family protein
 10-186 1.68e-53

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 170.46  E-value: 1.68e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlaKVDSSNG 89
Cdd:PLN02200   45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEM--ESSDNNK 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  90 FLIDGYPREVKQGEEFERKI-AQPTLLLYVDAGPETMTQRLLKRGEtsGRVDDNEETIKKRLETYYKATEPVISFYDKRG 168
Cdd:PLN02200  123 FLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                         170
                  ....*....|....*...
gi 1958759759 169 IVRKVNAEGSVDTVFSQV 186
Cdd:PLN02200  201 KLYTINAVGTVDEIFEQV 218
PRK14531 PRK14531
adenylate kinase; Provisional
 7-191 3.26e-48

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 155.35  E-value: 3.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   7 KAKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlaKVDS 86
Cdd:PRK14531    2 KQRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  87 SNGFLIDGYPREVKQGEEFE---RKIAQP---TLLLYVDagPETMTQRLLKRgetsGRVDDNEETIKKRLETYYKATEPV 160
Cdd:PRK14531   79 SGGWLLDGFPRTVAQAEALEpllEELKQPieaVVLLELD--DAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPL 152

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958759759 161 ISFYDKRGIVRKVNAEGSVDTVFSQVCTYLD 191
Cdd:PRK14531  153 IDHYRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14527 PRK14527
adenylate kinase; Provisional
 7-186 2.67e-46

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 150.71  E-value: 2.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   7 KAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDS 86
Cdd:PRK14527    5 KNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDE-LAGMEP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  87 SNgFLIDGYPREVKQGEEFERKIAQP----TLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIS 162
Cdd:PRK14527   84 VR-VIFDGFPRTLAQAEALDRLLEELgarlLAVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVD 162

                         170       180
                  ....*....|....*....|....
gi 1958759759 163 FYDKRGIVRKVNAEGSVDTVFSQV 186
Cdd:PRK14527  163 YYEARGHLKRVDGLGTPDEVYARI 186
PRK14532 PRK14532
adenylate kinase; Provisional
 10-182 5.45e-44

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 144.58  E-value: 5.45e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  10 IIFvvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDaMLAKVDSSNG 89
Cdd:PRK14532    4 ILF--GPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEE-RLPEAEAAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  90 FLIDGYPREVKQGEEFERKIA----QPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYD 165
Cdd:PRK14532   81 AIFDGFPRTVAQAEALDKMLAsrgqKIDVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPYYA 160

                         170
                  ....*....|....*..
gi 1958759759 166 KRGIVRKVNAEGSVDTV 182
Cdd:PRK14532  161 GQGKLTEVDGMGSIEAV 177
AAA_17 pfam13207
AAA domain;
14-147 4.79e-43

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 140.45  E-value: 4.79e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  14 VGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSsrGKMLSSIMEKGELVPLETVLDMLRDAmLAKVDSSNGFLID 93
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAER-IAEEAGEGGVIVD 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  94 GYPREVKQGEEFER------KIAQPTLLLYVDAGPETMTQRLLKRgETSGRVDDNEETIK 147
Cdd:pfam13207  78 GHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
PRK14528 PRK14528
adenylate kinase; Provisional
 9-186 5.89e-42

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 139.38  E-value: 5.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDaMLAKVDSSN 88
Cdd:PRK14528    3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKD-RIREADCKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  89 GFLIDGYPREVKQGEEFERKIAQPTL----LLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFY 164
Cdd:PRK14528   81 GFLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                         170       180
                  ....*....|....*....|..
gi 1958759759 165 DKRGIVRKVNAEGSVDTVFSQV 186
Cdd:PRK14528  161 AAQKKLSQVNGVGSLEEVTSLI 182
adk PRK02496
adenylate kinase; Provisional
 8-182 1.73e-41

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 138.34  E-value: 1.73e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   8 AKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDaMLAKVDSS 87
Cdd:PRK02496    2 TRLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQE-RLQQPDAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  88 NGFLIDGYPREVKQG---EEFERKIAQPT-LLLYVDAGPETMTQRLLKRgetsGRVDDNEETIKKRLETYYKATEPVISF 163
Cdd:PRK02496   80 NGWILDGFPRKVTQAaflDELLQEIGQSGeRVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDY 155

                         170
                  ....*....|....*....
gi 1958759759 164 YDKRGIVRKVNAEGSVDTV 182
Cdd:PRK02496  156 YRDRQKLLTIDGNQSVEAV 174
PRK14530 PRK14530
adenylate kinase; Provisional
 11-192 9.33e-37

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 127.21  E-value: 9.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRA---------EVSSGSSRgkmlsSIMEKGELVPLETVLDMLRDAMl 81
Cdd:PRK14530    6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqmdisdmDTEYDTPG-----EYMDAGELVPDAVVNEIVEEAL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  82 akvDSSNGFLIDGYPREVKQGEEFErKIAQPTLLLYVDAGPETMTQRLLKR---------------------------GE 134
Cdd:PRK14530   80 ---SDADGFVLDGYPRNLEQAEYLE-SITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqpeeegvcdecgGE 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958759759 135 TSGRVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLDS 192
Cdd:PRK14530  156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDD 213
PLN02842 PLN02842
nucleotide kinase
 13-191 2.03e-35

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 129.60  E-value: 2.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  13 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVDSSNGFLI 92
Cdd:PLN02842    2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  93 DGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKR-------------------GETSGRV----DDNEETIKKR 149
Cdd:PLN02842   82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppesEEIKARLitrpDDTEEKVKAR 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958759759 150 LETYYKATEPVISFYDKrgIVRKVNAEGSVDTVFSQVCTYLD 191
Cdd:PLN02842  162 LQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEISSLLS 201
PRK13808 PRK13808
adenylate kinase; Provisional
 11-167 1.36e-31

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 116.53  E-value: 1.36e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDaMLAKVDSSNGF 90
Cdd:PRK13808    3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISD-RIEQPDAANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  91 LIDGYPREVKQGEEFERKIAQPTLL------LYVDAGP-----ETMTQRLLKRGETSgRVDDNEETIKKRLETYYKATEP 159
Cdd:PRK13808   82 ILDGFPRTVPQAEALDALLKDKQLKldavveLRVNEGAllarvETRVAEMRARGEEV-RADDTPEVLAKRLASYRAQTEP 160


                  ....*....
gi 1958759759 160 VISFY-DKR 167
Cdd:PRK13808  161 LVHYYsEKR 169
PLN02674 PLN02674
adenylate kinase
 6-186 1.03e-29

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 109.59  E-value: 1.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   6 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlAKVD 85
Cdd:PLN02674   29 KPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAM-KKPS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  86 SSNGFLIDGYPREVKQGEEFERKIAQ------PTLLLYVDAG--PETMTQRLLKrgETSGRV------------------ 139
Cdd:PLN02674  108 CQKGFILDGFPRTVVQAQKLDEMLAKqgakidKVLNFAIDDAilEERITGRWIH--PSSGRTyhtkfappkvpgvddvtg 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958759759 140 -------DDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQV 186
Cdd:PLN02674  186 epliqrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEV 239
PLN02459 PLN02459
probable adenylate kinase
 15-168 4.63e-27

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 103.00  E-value: 4.63e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  15 GGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVD-SSNGFLID 93
Cdd:PLN02459   36 GCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEeGESGFILD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  94 GYPREVKQGEEFERkIAQPTLLLYVDAGPETMTQRLLKR---GETSG--------------------------------- 137
Cdd:PLN02459  116 GFPRTVRQAEILEG-VTDIDLVVNLKLREEVLVEKCLGRricSECGKnfnvadidlkgedgrpgivmppllpppecaskl 194

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958759759 138 --RVDDNEETIKKRLETYYKATEPVISFYDKRG 168
Cdd:PLN02459  195 itRADDTEEVVKARLRVYKEESQPVEDFYRKRG 227
PRK14526 PRK14526
adenylate kinase; Provisional
 9-182 6.26e-25

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 96.46  E-value: 6.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAkVDSSN 88
Cdd:PRK14526    2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINT-IKNND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  89 GFLIDGYPREVKQGEEFERKIAQPTLLLYVdAGPETMTQRLLKR---------------------------GETSGRVDD 141
Cdd:PRK14526   80 NFILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRrickscnnifniytlptkekgicdvckGDLYQRKDD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958759759 142 NEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTV 182
Cdd:PRK14526  159 KEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 4-169 3.08e-23

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 92.17  E-value: 3.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   4 KLKKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlAK 83
Cdd:PTZ00088    2 KLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEI-AK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  84 V--DSSNGFLIDGYPREVKQGEEFErKIAQPTLLLYVDAGPETMTQRLLKR----------------------------G 133
Cdd:PTZ00088   81 VtdDCFKGFILDGFPRNLKQCKELG-KITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958759759 134 ETSG---------RVDDNEETIKKRLETYYKATEPVISFYDKRGI 169
Cdd:PTZ00088  160 DCEGckgnpklqkRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14529 PRK14529
adenylate kinase; Provisional
 11-182 3.18e-17

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 76.30  E-value: 3.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMlaKVDSSNGF 90
Cdd:PRK14529    3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL--KQDGKNGW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  91 LIDGYPREVKQGEEFERKIAQPTLLL-YV--------DAGPETMTQRLLKR------------------------GETSG 137
Cdd:PRK14529   81 LLDGFPRNKVQAEKLWEALQKEGMKLdYVieillpreVAKNRIMGRRLCKNdnnhpnnifidaikpdgdvcrvcgGELST 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958759759 138 RVDD-NEETIKKRLETYYKATEPVIS---FY---DKRGIVR--KVNAEGSVDTV 182
Cdd:PRK14529  161 RADDqDEEAINKRHDIYYDTETGTLAaayFFkdlAAKGSTKyiELDGEGSIDEI 214
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 9-192 1.81e-08

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 51.89  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVVGGPGSGKGTQCEKIVQ---KYGYTHLSTGDLlraevsSGSSRGKMLSSIMEKGELVPLETVLDML-----RDAM 80
Cdd:cd01672     1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELLlfaadRAQH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  81 LAKV-----------------DSS---NGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVD 140
Cdd:cd01672    75 VEEVikpalargkivlsdrfvDSSlayQGAGRGLGEALIEALNDLATGGLKPDLTILLDIDPEVGLARIEARGRDDRDEQ 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958759759 141 DNEETIKKRLETYYKatepVISFYDKRGIVrkVNAEGSVDTVFSQVCTYLDS 192
Cdd:cd01672   155 EGLEFHERVREGYLE----LAAQEPERIIV--IDASQPLEEVLAEILKAILE 200
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 11-153 1.35e-07

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 48.85  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLssiMEKGELVPlETVLDMLRDAMLAKVDssngF 90
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSISYY---TDATDRTY-ERLHELARIALRAGRP----V 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958759759  91 LIDG---YPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSG-RVDDNEETIKKRLETY 153
Cdd:pfam13671  74 ILDAtnlRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARF 140
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
10-153 1.93e-07

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 48.76  E-value: 1.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTgDLLRAEVssgssRGKMLSSIMEKGELVPL--ETVLDMLRDAMLAKVDSs 87
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRL-----FGAGLAPLERSPEATARtyARLLALARELLAAGRSV- 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958759759  88 ngfLID-GYPREvKQGEEFeRKIAQ----PTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETY 153
Cdd:COG0645    74 ---ILDaTFLRR-AQREAF-RALAEeagaPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE 139
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
9-149 1.08e-05

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 44.17  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759   9 KIIFVVGGPGSGKGtQCEKIVQKYGYTHLSTGDLLRAEVSSG------SSRGKMLSSIMEKgelvpletvLDMLRDAMLA 82
Cdd:PRK01184    2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEVKKRgleptdENIGKVAIDLRKE---------LGMDAVAKRT 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958759759  83 ----KVDSSNGFLIDGYpREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRgetsGRVDDNE--ETIKKR 149
Cdd:PRK01184   72 vpkiREKGDEVVVIDGV-RGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKR----GRSDDPKswEELEER 139
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 10-53 1.23e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 43.24  E-value: 1.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958759759  10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSR 53
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEVGKLASE 44
PRK04182 PRK04182
cytidylate kinase; Provisional
 10-44 3.72e-04

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 39.40  E-value: 3.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958759759  10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLR 44
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFR 36
AAA_18 pfam13238
AAA domain;
11-144 3.59e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 36.25  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759759  11 IFVVGGPGSGKGTQCEKIVQKYGY----THLSTGDLLRAEVSSGSSRGKmlssIMEKGELVPLETVLDMLRDAMLAKVDS 86
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFgdnvRDLALENGLVLGDDPETRESK----RLDEDKLDRLLDLLEENAALEEGGNLI 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958759759  87 SNGFLIDGYPREVKQGEEFerkiaqptlllYVDAGPETMTQRLLKRGETSGRVDDNEE 144
Cdd:pfam13238  77 IDGHLAELEPERAKDLVGI-----------VLRASPEELLERLEKRGYEEAKIKENEE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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