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Arf1 ARF GTPase 1 [ Mus musculus (house mouse) ]

Gene ID: 11840, updated on 4-Jan-2025

Summary

Official Symbol
Arf1provided by MGI
Official Full Name
ARF GTPase 1provided by MGI
Primary source
MGI:MGI:99431
See related
Ensembl:ENSMUSG00000048076 AllianceGenome:MGI:99431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTP binding activity and magnesium ion binding activity. Involved in mitotic cleavage furrow ingression. Acts upstream of or within vesicle-mediated transport. Located in Golgi apparatus; cytosol; and sarcomere. Part of protein-containing complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ARF GTPase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in large intestine adult (RPKM 273.0), duodenum adult (RPKM 269.9) and 28 other tissues See more
Orthologs
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Genomic context

See Arf1 in Genome Data Viewer
Location:
11 B1.3; 11 37.05 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59102237..59119042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59211412..59228267, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5232 Neighboring gene RIKEN cDNA 2310033P09 gene Neighboring gene STARR-positive B cell enhancer ABC_E3955 Neighboring gene mitochondrial ribosomal protein L55 Neighboring gene wingless-type MMTV integration site family, member 3A Neighboring gene STARR-seq mESC enhancer starr_29621 Neighboring gene wingless-type MMTV integration site family, member 9A Neighboring gene predicted gene, 51865

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding  
enables GTP binding  
enables GTP binding PubMed 
enables GTP binding  
enables GTP binding PubMed 
enables GTPase activity  
enables magnesium ion binding PubMed 
enables magnesium ion binding  
enables phospholipase D activator activity  
enables protein binding PubMed 
enables protein domain specific binding  
enables protein domain specific binding  
Items 1 - 25 of 31
Process Evidence Code Pubs
involved_in Golgi to transport vesicle transport  
involved_in actin filament organization  
involved_in cellular response to virus  
involved_in cellular response to virus  
involved_in dendritic spine organization  
involved_in dendritic spine organization  
involved_in intracellular copper ion homeostasis  
involved_in intracellular copper ion homeostasis  
involved_in intracellular protein transport  
involved_in long-term synaptic depression  
involved_in long-term synaptic depression  
involved_in lysosomal membrane organization  
involved_in mitotic cleavage furrow ingression PubMed 
involved_in positive regulation of ER to Golgi vesicle-mediated transport  
involved_in positive regulation of calcium ion-dependent exocytosis  
involved_in positive regulation of dendritic spine development  
involved_in positive regulation of endocytosis  
involved_in positive regulation of late endosome to lysosome transport  
involved_in positive regulation of protein secretion  
involved_in positive regulation of sodium ion transmembrane transport  
involved_in postsynaptic actin cytoskeleton organization  
acts_upstream_of_or_within protein transport PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation  
involved_in regulation of Arp2/3 complex-mediated actin nucleation  
involved_in regulation of phospholipid metabolic process  
involved_in regulation of receptor internalization  
involved_in regulation of receptor internalization  
involved_in synaptic vesicle budding  
involved_in very-low-density lipoprotein particle assembly  
involved_in vesicle-mediated transport  
acts_upstream_of_or_within vesicle-mediated transport PubMed 
Items 1 - 25 of 31
Component Evidence Code Pubs
located_in COPI-coated vesicle  
located_in Golgi apparatus PubMed 
located_in Golgi membrane  
located_in Golgi membrane  
located_in cell leading edge  
located_in cell leading edge  
is_active_in cytoplasm  
located_in cytosol PubMed 
located_in endomembrane system PubMed 
is_active_in glutamatergic synapse  
located_in late endosome  
located_in neuron projection  
located_in peroxisomal membrane  
is_active_in plasma membrane  
located_in postsynaptic density  
is_active_in postsynaptic density  
part_of protein-containing complex PubMed 
part_of protein-containing complex  
located_in sarcomere PubMed 
located_in trans-Golgi network  

General protein information

Preferred Names
ADP-ribosylation factor 1
NP_001123880.1
NP_031502.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130408.2NP_001123880.1  ADP-ribosylation factor 1

    Status: VALIDATED

    Source sequence(s)
    AL645854
    Consensus CDS
    CCDS24765.1
    UniProtKB/Swiss-Prot
    P84078, Q3THZ2, Q3U849, Q3UDG1, Q3UF76
    Related
    ENSMUSP00000126120.2, ENSMUST00000163300.8
    Conserved Domains (1) summary
    smart00177
    Location:5179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
  2. NM_007476.4NP_031502.1  ADP-ribosylation factor 1

    Status: VALIDATED

    Source sequence(s)
    AL645854
    Consensus CDS
    CCDS24765.1
    UniProtKB/Swiss-Prot
    P84078, Q3THZ2, Q3U849, Q3UDG1, Q3UF76
    Related
    ENSMUSP00000079905.7, ENSMUST00000061242.8
    Conserved Domains (1) summary
    smart00177
    Location:5179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59102237..59119042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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