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ZNF518B zinc finger protein 518B [ Homo sapiens (human) ]

Gene ID: 85460, updated on 4-Jan-2025

Summary

Official Symbol
ZNF518Bprovided by HGNC
Official Full Name
zinc finger protein 518Bprovided by HGNC
Primary source
HGNC:HGNC:29365
See related
Ensembl:ENSG00000178163 MIM:617734; AllianceGenome:HGNC:29365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis (RPKM 4.9), thyroid (RPKM 3.6) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF518B in Genome Data Viewer
Location:
4p16.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (10439880..10461365, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (10415856..10437348, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (10441504..10459050, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:10412553-10413053 Neighboring gene dynein light chain Tctex-type 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:10458158-10458973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15281 Neighboring gene reactive intermediate imine deaminase A homolog pseudogene Neighboring gene uncharacterized LOC105374482 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:10497080-10498028 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:10498029-10498975 Neighboring gene cytokine dependent hematopoietic cell linker

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • KIAA1729

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375816.1NP_001362745.1  zinc finger protein 518B

    Status: VALIDATED

    Source sequence(s)
    AC110768
    Consensus CDS
    CCDS33960.1
    UniProtKB/Swiss-Prot
    Q96LN8, Q9C0D4
    Conserved Domains (2) summary
    sd00017
    Location:137157
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:164186
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. NM_001375817.1NP_001362746.1  zinc finger protein 518B

    Status: VALIDATED

    Source sequence(s)
    AC110768
    Consensus CDS
    CCDS33960.1
    UniProtKB/Swiss-Prot
    Q96LN8, Q9C0D4
    Conserved Domains (2) summary
    sd00017
    Location:137157
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:164186
    zf-H2C2_5; C2H2-type zinc-finger domain
  3. NM_053042.3NP_444270.2  zinc finger protein 518B

    See identical proteins and their annotated locations for NP_444270.2

    Status: VALIDATED

    Source sequence(s)
    AC110768, AL833306, BC040874, CD656908
    Consensus CDS
    CCDS33960.1
    UniProtKB/Swiss-Prot
    Q96LN8, Q9C0D4
    Related
    ENSP00000317614.3, ENST00000326756.4
    Conserved Domains (2) summary
    sd00017
    Location:137157
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:164186
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    10439880..10461365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416333.1XP_047272289.1  zinc finger protein 518B isoform X1

    UniProtKB/Swiss-Prot
    Q96LN8, Q9C0D4
  2. XM_024454264.2XP_024310032.1  zinc finger protein 518B isoform X1

    UniProtKB/Swiss-Prot
    Q96LN8, Q9C0D4
    Conserved Domains (2) summary
    sd00017
    Location:137157
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:164186
    zf-H2C2_5; C2H2-type zinc-finger domain
  3. XM_017008786.2XP_016864275.1  zinc finger protein 518B isoform X1

    UniProtKB/Swiss-Prot
    Q96LN8, Q9C0D4
    Conserved Domains (2) summary
    sd00017
    Location:137157
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:164186
    zf-H2C2_5; C2H2-type zinc-finger domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    10415856..10437348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351132.1XP_054207107.1  zinc finger protein 518B isoform X1

  2. XM_054351131.1XP_054207106.1  zinc finger protein 518B isoform X1

  3. XM_054351133.1XP_054207108.1  zinc finger protein 518B isoform X1

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