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zinc finger protein 518B [Homo sapiens]

NCBI Reference Sequence: NP_001362746.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001362746            1074 aa            linear   PRI 12-FEB-2024
DEFINITION  zinc finger protein 518B [Homo sapiens].
ACCESSION   NP_001362746 XP_005248250
VERSION     NP_001362746.1
DBSOURCE    REFSEQ: accession NM_001375817.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1074)
  AUTHORS   Riffo-Campos,A.L., Castillo,J., Vallet-Sanchez,A., Ayala,G.,
            Cervantes,A., Lopez-Rodas,G. and Franco,L.
  TITLE     In silico RNA-seq and experimental analyses reveal the differential
            expression and splicing of EPDR1 and ZNF518B genes in relation to
            KRAS mutations in colorectal cancer cells
  JOURNAL   Oncol Rep 36 (6), 3627-3634 (2016)
   PUBMED   27805251
  REMARK    GeneRIF: ZNF518B exhibits a pattern of isoform abundance dependent
            on KRAS G13D and G12D mutations.
REFERENCE   2  (residues 1 to 1074)
  AUTHORS   Zhang,X.Y., Geng,T.T., Liu,L.J., Yuan,D.Y., Feng,T., Kang,L.L.,
            Jin,T.B. and Chen,C.
  TITLE     SLC2A9 and ZNF518B polymorphisms correlate with gout-related
            metabolic indices in Chinese Tibetan populations
  JOURNAL   Genet Mol Res 14 (3), 9915-9921 (2015)
   PUBMED   26345926
  REMARK    GeneRIF: SLC2A9 and ZNF518B polymorphisms correlate with
            gout-related metabolic indices in Chinese Tibetan populations
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1074)
  AUTHORS   Jin,T.B., Ren,Y., Shi,X., Jiri,M., He,N., Feng,T., Yuan,D. and
            Kang,L.
  TITLE     Genetic variations in the CLNK gene and ZNF518B gene are associated
            with gout in case-control sample sets
  JOURNAL   Rheumatol Int 35 (7), 1141-1147 (2015)
   PUBMED   25591661
  REMARK    GeneRIF: CLNK and ZNF518B SNPs may have potential as diagnostic and
            prognostic marker for Chinese gout patients.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110768.5.
            
            On Nov 5, 2019 this sequence version replaced XP_005248250.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.24563.1,
                                           SRR14038194.3079797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     Protein         1..1074
                     /product="zinc finger protein 518B"
                     /calculated_mol_wt=119401
     Region          12..36
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9C0D4.2)"
     Region          137..157
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(142,144,146,148..149,152..153,156,169,175..176,
                     179..180,183,197,199,201,203..204,207..208,212)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          164..186
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          164..184
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          192..213
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          568..590
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9C0D4.2)"
     Region          603..632
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9C0D4.2)"
     Region          678..704
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9C0D4.2)"
     CDS             1..1074
                     /gene="ZNF518B"
                     /coded_by="NM_001375817.1:322..3546"
                     /db_xref="CCDS:CCDS33960.1"
                     /db_xref="GeneID:85460"
                     /db_xref="HGNC:HGNC:29365"
                     /db_xref="MIM:617734"
ORIGIN      
        1 mkdigqqlyt thlngghnsl tmspkqpdan gaprpnrqea qtllyqgsea eaammtiatc
       61 akcksvhkis lqdlqkgtgk dgmyvcfqcs lgaappnfhf vsnnssathv gnktenfsss
      121 vnskfkvrnf kpgkyycdkc rfstkdplqy kkhtlqheei kficshcsyi sytkgefqrh
      181 lvkhtgifpy qceycdygai rndyivkhtk rvheragakr pvkavaklep krtgtskqnp
      241 ellkasnprt tfqnkwsdql sgfslhankd kmhnimllpe pkeyqkdvvc ipnkmtlsep
      301 nevnlfenkn vevevlspak epvqpgmplt vvapaelvvp anclaqlidv kvvngtqqlv
      361 lklfpleenn cleagrdngg nsermvkekg sneqekvlsa ektksltvdg nvgklvgids
      421 fqpsvqkqlk nvkwvrsydf impnssvhnn gksfinseti edfqkknnly phrtafpsva
      481 lkghslasvf knsvlrslga asnpfpykaa vcfaesgrnl hsssqqllpf aaspatcsfs
      541 gekgllpvse ndlestskvn ipvkvvssnr kqednqteeh kavstvgqis sqhkseylhi
      601 nitgedrsqq pgdkplelkn sertnntndg pvissvfsls sgsenvpegi kwnsstskik
      661 siellrrkia qliescgkps slasnsahrr svgqaskgts katsegiqei nvsltglghs
      721 tgtlqkppnd ggitgnrqlt hqqiyphfad gsnrktksrv arkahvatpv lipkgavlrv
      781 lnssenahii eatceapvsi pcserqlikp vpfcpvrqad sdlqplrser gpidmspnie
      841 tplrpklrke savcstihrk tgllygqqgs selnkqgrll srslsisrnk tkqvhlsrkk
      901 nkiqaepsrc lkdpsifqva rqlrliaakp dqlikcprrn qpvivlnhpd vdspevtnvm
      961 kvinkykgnv lkvvlsertr cqlgirrhhv rltyqnaeea sqikrqmmlk mklkkvhknn
     1021 yqvvdslpdd ssqcvfkcwf cgrlyedqee wmshgqrhli eatrdwdvls skgk
//
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