LOCUS NP_001362746 1074 aa linear PRI 12-FEB-2024
DEFINITION zinc finger protein 518B [Homo sapiens].
ACCESSION NP_001362746 XP_005248250
VERSION NP_001362746.1
DBSOURCE REFSEQ: accession NM_001375817.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 1074)
AUTHORS Riffo-Campos,A.L., Castillo,J., Vallet-Sanchez,A., Ayala,G.,
Cervantes,A., Lopez-Rodas,G. and Franco,L.
TITLE In silico RNA-seq and experimental analyses reveal the differential
expression and splicing of EPDR1 and ZNF518B genes in relation to
KRAS mutations in colorectal cancer cells
JOURNAL Oncol Rep 36 (6), 3627-3634 (2016)
PUBMED 27805251
REMARK GeneRIF: ZNF518B exhibits a pattern of isoform abundance dependent
on KRAS G13D and G12D mutations.
REFERENCE 2 (residues 1 to 1074)
AUTHORS Zhang,X.Y., Geng,T.T., Liu,L.J., Yuan,D.Y., Feng,T., Kang,L.L.,
Jin,T.B. and Chen,C.
TITLE SLC2A9 and ZNF518B polymorphisms correlate with gout-related
metabolic indices in Chinese Tibetan populations
JOURNAL Genet Mol Res 14 (3), 9915-9921 (2015)
PUBMED 26345926
REMARK GeneRIF: SLC2A9 and ZNF518B polymorphisms correlate with
gout-related metabolic indices in Chinese Tibetan populations
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 1074)
AUTHORS Jin,T.B., Ren,Y., Shi,X., Jiri,M., He,N., Feng,T., Yuan,D. and
Kang,L.
TITLE Genetic variations in the CLNK gene and ZNF518B gene are associated
with gout in case-control sample sets
JOURNAL Rheumatol Int 35 (7), 1141-1147 (2015)
PUBMED 25591661
REMARK GeneRIF: CLNK and ZNF518B SNPs may have potential as diagnostic and
prognostic marker for Chinese gout patients.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC110768.5.
On Nov 5, 2019 this sequence version replaced XP_005248250.1.
##Evidence-Data-START##
Transcript exon combination :: SRR11853559.24563.1,
SRR14038194.3079797.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2153733 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1074
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p16.1"
Protein 1..1074
/product="zinc finger protein 518B"
/calculated_mol_wt=119401
Region 12..36
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9C0D4.2)"
Region 137..157
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(142,144,146,148..149,152..153,156,169,175..176,
179..180,183,197,199,201,203..204,207..208,212)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 164..186
/region_name="zf-H2C2_5"
/note="C2H2-type zinc-finger domain; pfam13909"
/db_xref="CDD:404746"
Region 164..184
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 192..213
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 568..590
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9C0D4.2)"
Region 603..632
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9C0D4.2)"
Region 678..704
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9C0D4.2)"
CDS 1..1074
/gene="ZNF518B"
/coded_by="NM_001375817.1:322..3546"
/db_xref="CCDS:CCDS33960.1"
/db_xref="GeneID:85460"
/db_xref="HGNC:HGNC:29365"
/db_xref="MIM:617734"
ORIGIN
1 mkdigqqlyt thlngghnsl tmspkqpdan gaprpnrqea qtllyqgsea eaammtiatc
61 akcksvhkis lqdlqkgtgk dgmyvcfqcs lgaappnfhf vsnnssathv gnktenfsss
121 vnskfkvrnf kpgkyycdkc rfstkdplqy kkhtlqheei kficshcsyi sytkgefqrh
181 lvkhtgifpy qceycdygai rndyivkhtk rvheragakr pvkavaklep krtgtskqnp
241 ellkasnprt tfqnkwsdql sgfslhankd kmhnimllpe pkeyqkdvvc ipnkmtlsep
301 nevnlfenkn vevevlspak epvqpgmplt vvapaelvvp anclaqlidv kvvngtqqlv
361 lklfpleenn cleagrdngg nsermvkekg sneqekvlsa ektksltvdg nvgklvgids
421 fqpsvqkqlk nvkwvrsydf impnssvhnn gksfinseti edfqkknnly phrtafpsva
481 lkghslasvf knsvlrslga asnpfpykaa vcfaesgrnl hsssqqllpf aaspatcsfs
541 gekgllpvse ndlestskvn ipvkvvssnr kqednqteeh kavstvgqis sqhkseylhi
601 nitgedrsqq pgdkplelkn sertnntndg pvissvfsls sgsenvpegi kwnsstskik
661 siellrrkia qliescgkps slasnsahrr svgqaskgts katsegiqei nvsltglghs
721 tgtlqkppnd ggitgnrqlt hqqiyphfad gsnrktksrv arkahvatpv lipkgavlrv
781 lnssenahii eatceapvsi pcserqlikp vpfcpvrqad sdlqplrser gpidmspnie
841 tplrpklrke savcstihrk tgllygqqgs selnkqgrll srslsisrnk tkqvhlsrkk
901 nkiqaepsrc lkdpsifqva rqlrliaakp dqlikcprrn qpvivlnhpd vdspevtnvm
961 kvinkykgnv lkvvlsertr cqlgirrhhv rltyqnaeea sqikrqmmlk mklkkvhknn
1021 yqvvdslpdd ssqcvfkcwf cgrlyedqee wmshgqrhli eatrdwdvls skgk
//