U.S. flag

An official website of the United States government

HECTD2 HECT domain E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 143279, updated on 4-Jan-2025

Summary

Official Symbol
HECTD2provided by HGNC
Official Full Name
HECT domain E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:26736
See related
Ensembl:ENSG00000165338 MIM:620876; AllianceGenome:HGNC:26736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in prostate (RPKM 5.7), brain (RPKM 4.5) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HECTD2 in Genome Data Viewer
Location:
10q23.32
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (91409235..91514820)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (92292590..92398174)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93168992..93274577)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:92923911-92924447 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:92932029-92932262 Neighboring gene uncharacterized LOC124902480 Neighboring gene nudix hydrolase 9 pseudogene 1 Neighboring gene polycomb group ring finger 5 Neighboring gene Sharpr-MPRA regulatory region 216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3762 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:93007586-93007768 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:93044145-93044720 Neighboring gene HECTD2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2607 Neighboring gene MPRA-validated peak1048 silencer Neighboring gene uncharacterized LOC105378433 Neighboring gene ribosomal protein S27 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • FLJ16050

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol  

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase HECTD2
Names
HECT domain containing E3 ubiquitin protein ligase 2
HECT domain-containing protein 2
HECT-type E3 ubiquitin transferase HECTD2
NP_001271203.2
NP_001335294.1
NP_775768.4
NP_877497.4
XP_024303596.1
XP_047280612.1
XP_047280613.1
XP_047280614.1
XP_047280615.1
XP_047280616.1
XP_047280617.1
XP_047280618.1
XP_054220883.1
XP_054220884.1
XP_054220885.1
XP_054220886.1
XP_054220887.1
XP_054220888.1
XP_054220889.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284274.3NP_001271203.2  probable E3 ubiquitin-protein ligase HECTD2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC023902, AL161798
    Consensus CDS
    CCDS60591.1
    UniProtKB/TrEMBL
    B4DIQ2, E7ERR3
    Related
    ENSP00000401023.1, ENST00000446394.5
    Conserved Domains (1) summary
    cd00078
    Location:421778
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. NM_001348365.2NP_001335294.1  probable E3 ubiquitin-protein ligase HECTD2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' terminal exon and lacks an alternate in-frame exon in the 5' coding region compared to variant 3. These differences result in the use of a downstream start codon compared to variant 3. The encoded isoform (d) has a shorter N-terminus compared to isoform c
    Source sequence(s)
    AC023902, AL161798, BC036487
    UniProtKB/TrEMBL
    B4DIQ2
    Conserved Domains (1) summary
    cd00078
    Location:310667
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  3. NM_173497.4NP_775768.4  probable E3 ubiquitin-protein ligase HECTD2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform c.
    Source sequence(s)
    AC023902, AL161798
    Consensus CDS
    CCDS7415.1
    Related
    ENSP00000360746.4, ENST00000371681.8
  4. NM_182765.6NP_877497.4  probable E3 ubiquitin-protein ligase HECTD2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region compared to variant 3. It encodes isoform a which is shorter compared to isoform c.
    Source sequence(s)
    AC023902, AL161798
    Consensus CDS
    CCDS7414.1
    UniProtKB/Swiss-Prot
    Q5U5R9, Q5VZ97, Q5VZ98, Q5VZ99, Q8N1X7, Q8TCP5
    UniProtKB/TrEMBL
    B4DIQ2
    Related
    ENSP00000298068.5, ENST00000298068.10
    Conserved Domains (1) summary
    cd00078
    Location:417774
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. NR_104291.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple difference compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023902, AL161798
  2. NR_145526.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon and uses alternate splice sites in two internal exon compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023902, AL161798

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    91409235..91514820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424658.1XP_047280614.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

    UniProtKB/TrEMBL
    B4DIQ2
  2. XM_047424659.1XP_047280615.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

    UniProtKB/TrEMBL
    B4DIQ2
  3. XM_047424660.1XP_047280616.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

    UniProtKB/TrEMBL
    B4DIQ2
  4. XM_047424656.1XP_047280612.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X1

    UniProtKB/TrEMBL
    B4DIQ2
  5. XM_047424661.1XP_047280617.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

  6. XM_047424662.1XP_047280618.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X5

  7. XM_024447828.2XP_024303596.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

    UniProtKB/TrEMBL
    B4DIQ2
    Conserved Domains (1) summary
    cd00078
    Location:310667
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  8. XM_047424657.1XP_047280613.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

    UniProtKB/TrEMBL
    B4DIQ2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    92292590..92398174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364910.1XP_054220885.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

    UniProtKB/TrEMBL
    B4DIQ2
  2. XM_054364912.1XP_054220887.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

    UniProtKB/TrEMBL
    B4DIQ2
  3. XM_054364908.1XP_054220883.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X1

    UniProtKB/TrEMBL
    B4DIQ2
  4. XM_054364913.1XP_054220888.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

  5. XM_054364914.1XP_054220889.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X5

  6. XM_054364911.1XP_054220886.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

    UniProtKB/TrEMBL
    B4DIQ2
  7. XM_054364909.1XP_054220884.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

    UniProtKB/TrEMBL
    B4DIQ2
External link. Please review our privacy policy.