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HNT3 DNA 5'-adenosine monophosphate hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854432, updated on 4-Jan-2025

Summary

Official Symbol
HNT3
Official Full Name
DNA 5'-adenosine monophosphate hydrolase
Primary source
SGD:S000005784
Locus tag
YOR258W
See related
AllianceGenome:SGD:S000005784; FungiDB:YOR258W; VEuPathDB:YOR258W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA 5'-adenosine monophosphate hydrolase activity. Involved in DNA damage response. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 1 and olivopontocerebellar atrophy. Orthologous to human APTX (aprataxin). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See HNT3 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (811671..812324)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative zinc metalloprotease Neighboring gene centrin Neighboring gene proteasome regulatory particle base subunit RPT4 Neighboring gene translation initiation factor eIF2B subunit gamma

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA 5'-adenosine monophosphate hydrolase activity  
enables DNA 5'-adenosine monophosphate hydrolase activity PubMed 
enables DNA 5'-adenosine monophosphate hydrolase activity  
enables DNA binding  
enables DNA-3'-diphospho-5'-guanosine diphosphatase  
enables catalytic activity  
enables double-stranded RNA binding  
enables hydrolase activity  
enables metal ion binding  
enables mismatched DNA binding  
enables single-strand break-containing DNA binding  
enables single-stranded DNA binding  
enables zinc ion binding PubMed 
Process Evidence Code Pubs
involved_in DNA damage response PubMed 
involved_in DNA damage response PubMed 
involved_in DNA repair  
involved_in nucleobase-containing compound metabolic process  
involved_in single strand break repair  
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in nucleus PubMed 
is_active_in nucleus  
located_in nucleus  

General protein information

Preferred Names
DNA 5'-adenosine monophosphate hydrolase
NP_014901.1
  • DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    811671..812324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183677.1NP_014901.1  TPA: DNA 5'-adenosine monophosphate hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2V9, Q05189, Q08702
    UniProtKB/TrEMBL
    B3LJS6, C7GWD1, C8ZH09, N1NYS3
    Conserved Domains (2) summary
    pfam01230
    Location:15139
    HIT; HIT domain
    pfam16278
    Location:153212
    zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
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