U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Pdcd10 programmed cell death 10 [ Mus musculus (house mouse) ]

    Gene ID: 56426, updated on 4-Jan-2025

    Summary

    Official Symbol
    Pdcd10provided by MGI
    Official Full Name
    programmed cell death 10provided by MGI
    Primary source
    MGI:MGI:1928396
    See related
    Ensembl:ENSMUSG00000027835 AllianceGenome:MGI:1928396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccm3; Tfa15; Tfar15; 2410003B13Rik
    Summary
    Predicted to enable protein homodimerization activity and protein kinase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in Golgi membrane; cell periphery; and cytosol. Predicted to be part of FAR/SIN/STRIPAK complex. Is expressed in several structures, including cardiovascular system; central nervous system; gonad; gut; and retina layer. Used to study cerebral cavernous malformation 3. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in placenta adult (RPKM 13.4), bladder adult (RPKM 12.3) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pdcd10 in Genome Data Viewer
    Location:
    3 E3; 3 33.76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (75423797..75464159, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (75516490..75556852, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade I, member 2 Neighboring gene WD repeat domain 49 Neighboring gene predicted gene, 17836 Neighboring gene STARR-positive B cell enhancer ABC_E2071 Neighboring gene serine (or cysteine) peptidase inhibitor, clade I, member 1 Neighboring gene STARR-seq mESC enhancer starr_07971 Neighboring gene pluripotency associated transcript 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Interactions

    General gene information

    Clone Names

    • MGC102058

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase binding  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in Golgi reassembly  
    involved_in Golgi reassembly  
    involved_in Golgi reassembly  
    involved_in angiogenesis  
    involved_in cellular response to anoxia  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor PubMed 
    involved_in endothelium development PubMed 
    involved_in establishment of Golgi localization  
    involved_in establishment of Golgi localization  
    involved_in intracellular signal transduction  
    involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide  
    involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
    involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of inflammatory response  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of mesenchymal cell apoptotic process  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of angiogenesis PubMed 
    involved_in short-term memory  
    involved_in wound healing, spreading of cells  
    involved_in wound healing, spreading of cells  
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex  
    part_of FAR/SIN/STRIPAK complex  
    part_of FAR/SIN/STRIPAK complex  
    colocalizes_with Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in Golgi membrane  
    located_in cell periphery  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in plasma membrane  

    General protein information

    Preferred Names
    programmed cell death protein 10
    Names
    TF-1 cell apoptosis-related protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019745.4NP_062719.2  programmed cell death protein 10

      See identical proteins and their annotated locations for NP_062719.2

      Status: VALIDATED

      Source sequence(s)
      AC140430, AK075926, BC086778, BY091056
      Consensus CDS
      CCDS17414.1
      UniProtKB/Swiss-Prot
      Q8VE70, Q9DAR3, Q9WV43
      Related
      ENSMUSP00000125752.2, ENSMUST00000161137.8
      Conserved Domains (1) summary
      pfam06840
      Location:14161
      DUF1241; Protein of unknown function (DUF1241)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      75423797..75464159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.