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Abcd3 ATP-binding cassette, sub-family D member 3 [ Mus musculus (house mouse) ]

Gene ID: 19299, updated on 4-Jan-2025

Summary

Official Symbol
Abcd3provided by MGI
Official Full Name
ATP-binding cassette, sub-family D member 3provided by MGI
Primary source
MGI:MGI:1349216
See related
Ensembl:ENSMUSG00000028127 AllianceGenome:MGI:1349216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PMP68; PMP70; Pxmp1
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver adult (RPKM 16.9), bladder adult (RPKM 15.9) and 27 other tissues See more
Orthologs
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Genomic context

See Abcd3 in Genome Data Viewer
Location:
3 G1; 3 52.94 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (121552553..121609851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121758904..121815302, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930432M17 gene Neighboring gene coagulation factor III Neighboring gene STARR-seq mESC enhancer starr_08863 Neighboring gene STARR-seq mESC enhancer starr_08864 Neighboring gene predicted gene, 33924 Neighboring gene predicted gene, 33987

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity  
enables ATP binding  
enables ATP binding  
enables ATP binding  
enables ATP hydrolysis activity  
enables ATP hydrolysis activity  
enables ATPase-coupled transmembrane transporter activity  
enables ATPase-coupled transmembrane transporter activity  
enables fatty acyl-CoA hydrolase activity  
enables fatty acyl-CoA hydrolase activity  
enables identical protein binding  
enables long-chain fatty acid transmembrane transporter activity  
enables long-chain fatty acid transmembrane transporter activity  
enables long-chain fatty acid transmembrane transporter activity  
enables protein binding PubMed 
enables protein homodimerization activity  
enables protein homodimerization activity  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport PubMed 
involved_in bile acid biosynthetic process PubMed 
involved_in fatty acid beta-oxidation  
involved_in fatty acid beta-oxidation  
involved_in fatty acid beta-oxidation  
involved_in fatty acid biosynthetic process  
involved_in fatty acid biosynthetic process  
involved_in lipid transport PubMed 
involved_in long-chain fatty acid import into peroxisome  
involved_in long-chain fatty acid import into peroxisome  
involved_in long-chain fatty acid import into peroxisome  
involved_in peroxisome organization  
involved_in peroxisome organization  
involved_in peroxisome organization  
involved_in phytanic acid metabolic process PubMed 
involved_in response to organic cyclic compound  
involved_in response to xenobiotic stimulus  
involved_in very long-chain fatty acid catabolic process  
involved_in very long-chain fatty acid catabolic process  
involved_in very long-chain fatty acid catabolic process  
involved_in very long-chain fatty acid metabolic process  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle  
located_in mitochondrial inner membrane PubMed 
located_in mitochondrion PubMed 
located_in mitochondrion  
located_in peroxisomal matrix  
located_in peroxisomal matrix  
is_active_in peroxisomal membrane  
located_in peroxisomal membrane PubMed 
located_in peroxisomal membrane  
located_in peroxisome PubMed 
located_in peroxisome PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family D member 3
Names
68 kDa peroxisomal membrane protein
70 kDa peroxisomal membrane protein
ATP-binding cassette, sub-family D (ALD), member 3
peroxisomal membrane protein 1
peroxisomal membrane protein, 70 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355756.2NP_001342685.1  ATP-binding cassette sub-family D member 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129311
    UniProtKB/TrEMBL
    Q3U645, Q3UNS0, Q91VT3, Q9DBZ6
    Conserved Domains (1) summary
    TIGR00954
    Location:1574
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
  2. NM_001409848.1NP_001396777.1  ATP-binding cassette sub-family D member 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129311
    UniProtKB/TrEMBL
    Q3U645, Q3UNS0, Q91VT3, Q9DBZ6
  3. NM_001409849.1NP_001396778.1  ATP-binding cassette sub-family D member 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC129311
    UniProtKB/TrEMBL
    Q3U645, Q3UNS0, Q91VT3, Q9DBZ6
  4. NM_001409850.1NP_001396779.1  ATP-binding cassette sub-family D member 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC129311
    UniProtKB/TrEMBL
    A0A0G2JDI9, Q3U645, Q3UNS0, Q91VT3, Q9DBZ6
    Related
    ENSMUSP00000142387.2, ENSMUST00000197383.5
  5. NM_001409851.1NP_001396780.1  ATP-binding cassette sub-family D member 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129311
    UniProtKB/TrEMBL
    Q3U645, Q3UNS0, Q91VT3, Q9DBZ6
  6. NM_008991.4NP_033017.2  ATP-binding cassette sub-family D member 3 isoform 1

    See identical proteins and their annotated locations for NP_033017.2

    Status: VALIDATED

    Source sequence(s)
    AC129311
    Consensus CDS
    CCDS17806.1
    UniProtKB/Swiss-Prot
    P55096
    UniProtKB/TrEMBL
    Q3U645, Q3UNS0, Q91VT3, Q9DBZ6
    Related
    ENSMUSP00000029770.6, ENSMUST00000029770.8
    Conserved Domains (3) summary
    cd03223
    Location:440645
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    TIGR00954
    Location:1647
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    pfam06472
    Location:59338
    ABC_membrane_2; ABC transporter transmembrane region 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    121552553..121609851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162959.1XP_036018852.1  ATP-binding cassette sub-family D member 3 isoform X1

    UniProtKB/TrEMBL
    Q3U645, Q3UNS0, Q91VT3, Q9DBZ6
    Conserved Domains (1) summary
    TIGR00954
    Location:1647
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
  2. XM_036162960.1XP_036018853.1  ATP-binding cassette sub-family D member 3 isoform X2

    Conserved Domains (1) summary
    TIGR00954
    Location:1515
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
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