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Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) [ Mus musculus (house mouse) ]

Gene ID: 240057, updated on 9-Dec-2024

Summary

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Official Symbol
Syngap1provided by MGI
Official Full Name
synaptic Ras GTPase activating protein 1 homolog (rat)provided by MGI
Primary source
MGI:MGI:3039785
See related
Ensembl:ENSMUSG00000067629 AllianceGenome:MGI:3039785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1963; Syngap
Summary
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]
Expression
Broad expression in frontal lobe adult (RPKM 23.1), cortex adult (RPKM 20.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Syngap1 in Genome Data Viewer
Location:
17 A3.3; 17 13.6 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27160186..27191408)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26941212..26972434)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E487 Neighboring gene microRNA 6968 Neighboring gene PHD finger protein 1 Neighboring gene cutA divalent cation tolerance homolog Neighboring gene microRNA 3083b Neighboring gene microRNA 3083 Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27137073-27137182 Neighboring gene STARR-positive B cell enhancer ABC_E11633 Neighboring gene gametogenetin binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27164461-27164644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27165231-27165340 Neighboring gene BCL2-antagonist/killer 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability. Fenton TA, et al. Transl Psychiatry, 2024 Oct 2. PMID 39358332, Free PMC Article
  2. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly. Aceti M, et al. Biol Psychiatry, 2015 May 1. PMID 25444158, Free PMC Article
  3. Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function. Berryer MH, et al. Nat Commun, 2016 Nov 9. PMID 27827368, Free PMC Article
  4. SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity. Clement JP, et al. J Neurosci, 2013 Jun 19. PMID 23785156, Free PMC Article
  5. Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout. Muhia M, et al. Learn Mem, 2012 Jun 14. PMID 22700469

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability.
    Title: Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability.
  2. SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.
    Title: SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.
  3. Mouse models of SYNGAP1-related intellectual disability.
    Title: Mouse models of SYNGAP1-related intellectual disability.
  4. Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing.
    Title: Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing.
  5. Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction.
    Title: Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction.
  6. Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection.
    Title: Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection.
  7. Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
    Title: Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
  8. Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening.
    Title: Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening.
  9. SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity.
    Title: SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity.
  10. pSynGAP1 disturbance-mediated hippocampal oscillation network impairment might contribute to long-term neurobehavioral abnormities in sepsis survivors.
    Title: pSynGAP1 disturbance-mediated hippocampal oscillation network impairment might contribute to long-term neurobehavioral abnormities in sepsis survivors.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of postsynaptic specialization structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maintenance of postsynaptic specialization structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within receptor clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras/Rap GTPase-activating protein SynGAP
Names
neuronal RasGAP
ras GTPase-activating protein SynGAP
synaptic Ras GTPase-activating protein 1
synaptic Ras-GAP 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281491.2 → NP_001268420.1  ras/Rap GTPase-activating protein SynGAP isoform 1

    See identical proteins and their annotated locations for NP_001268420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC144621
    Consensus CDS
    CCDS59625.1
    UniProtKB/Swiss-Prot
    F6SEU4
    UniProtKB/TrEMBL
    A0A2S1B6B8
    Related
    ENSMUSP00000141686.2, ENSMUST00000194598.6
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1307
    DUF3498; Domain of unknown function (DUF3498)

  2. NM_001371033.1 → NP_001357962.1  ras/Rap GTPase-activating protein SynGAP isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC144621
    UniProtKB/TrEMBL
    A0A2S1B6B8
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1305
    DUF3498; Domain of unknown function (DUF3498)

  3. NM_001371034.1 → NP_001357963.1  ras/Rap GTPase-activating protein SynGAP isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC144621
    UniProtKB/TrEMBL
    A0A0J9YVH8
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1245
    DUF3498; Domain of unknown function (DUF3498)

  4. NM_001394027.1 → NP_001380956.1  ras/Rap GTPase-activating protein SynGAP isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC144621
    UniProtKB/TrEMBL
    A0A2S1B6F9
    Related
    ENSMUSP00000080038.5, ENSMUST00000081285.9
    Conserved Domains (4) summary
    cd04013
    Location:166 → 328
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:319 → 642
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:36 → 227
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:1084 → 1207
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27160186..27191408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524237.2 → XP_006524300.1  ras/Rap GTPase-activating protein SynGAP isoform X5

    UniProtKB/TrEMBL
    A0A0J9YUM2
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1278
    DUF3498; Domain of unknown function (DUF3498)

  2. XM_006524245.3 → XP_006524308.1  ras/Rap GTPase-activating protein SynGAP isoform X14

    See identical proteins and their annotated locations for XP_006524308.1

    UniProtKB/TrEMBL
    A0A0J9YVH8
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1261
    DUF3498; Domain of unknown function (DUF3498)

  3. XM_006524240.2 → XP_006524303.1  ras/Rap GTPase-activating protein SynGAP isoform X7

    UniProtKB/TrEMBL
    A0A2S1B6B8
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1308
    DUF3498; Domain of unknown function (DUF3498)

  4. XM_030249787.1 → XP_030105647.1  ras/Rap GTPase-activating protein SynGAP isoform X15

    UniProtKB/TrEMBL
    A0A0J9YVH8
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1259
    DUF3498; Domain of unknown function (DUF3498)

  5. XM_030249784.1 → XP_030105644.1  ras/Rap GTPase-activating protein SynGAP isoform X9

    UniProtKB/TrEMBL
    A0A2S1B6B8
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1291
    DUF3498; Domain of unknown function (DUF3498)

  6. XM_006524247.2 → XP_006524310.1  ras/Rap GTPase-activating protein SynGAP isoform X14

    See identical proteins and their annotated locations for XP_006524310.1

    UniProtKB/TrEMBL
    A0A0J9YVH8
    Related
    ENSMUSP00000144666.3, ENSMUST00000201349.6
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1261
    DUF3498; Domain of unknown function (DUF3498)

  7. XM_036160599.1 → XP_036016492.1  ras/Rap GTPase-activating protein SynGAP isoform X14

    UniProtKB/TrEMBL
    A0A0J9YVH8
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1261
    DUF3498; Domain of unknown function (DUF3498)

  8. XM_006524235.2 → XP_006524298.1  ras/Rap GTPase-activating protein SynGAP isoform X1

    UniProtKB/TrEMBL
    A0A2R8VHH2
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1292
    DUF3498; Domain of unknown function (DUF3498)

  9. XM_006524243.2 → XP_006524306.1  ras/Rap GTPase-activating protein SynGAP isoform X12

    UniProtKB/TrEMBL
    J3QQ18
    Related
    ENSMUSP00000141245.3, ENSMUST00000193200.6
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1292
    DUF3498; Domain of unknown function (DUF3498)

  10. XM_006524236.2 → XP_006524299.1  ras/Rap GTPase-activating protein SynGAP isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHH2
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1290
    DUF3498; Domain of unknown function (DUF3498)

  11. XM_030249783.1 → XP_030105643.1  ras/Rap GTPase-activating protein SynGAP isoform X3

    UniProtKB/TrEMBL
    A0A0J9YUM2
    Conserved Domains (4) summary
    cd04013
    Location:252 → 414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405 → 728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122 → 313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:718 → 1276
    DUF3498; Domain of unknown function (DUF3498)

  12. XM_006524241.3 → XP_006524304.1  ras/Rap GTPase-activating protein SynGAP isoform X8

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:176 → 338
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:329 → 652
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:46 → 237
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:642 → 1216
    DUF3498; Domain of unknown function (DUF3498)

  13. XM_030249791.1 → XP_030105651.1  ras/Rap GTPase-activating protein SynGAP isoform X21

    Conserved Domains (2) summary
    pfam12004
    Location:116 → 659
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1 → 126
    RasGAP; Ras GTPase Activating Domain

  14. XM_036160597.1 → XP_036016490.1  ras/Rap GTPase-activating protein SynGAP isoform X4

    UniProtKB/TrEMBL
    A0A0A6YVS6
    Conserved Domains (4) summary
    cd04013
    Location:224 → 386
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:377 → 700
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:94 → 285
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:690 → 1264
    DUF3498; Domain of unknown function (DUF3498)

  15. XM_006524238.5 → XP_006524301.1  ras/Rap GTPase-activating protein SynGAP isoform X4

    See identical proteins and their annotated locations for XP_006524301.1

    UniProtKB/TrEMBL
    A0A0A6YVS6
    Conserved Domains (4) summary
    cd04013
    Location:224 → 386
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:377 → 700
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:94 → 285
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:690 → 1264
    DUF3498; Domain of unknown function (DUF3498)

  16. XM_030249786.1 → XP_030105646.1  ras/Rap GTPase-activating protein SynGAP isoform X13

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:135 → 297
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:288 → 611
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:5 → 196
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:601 → 1175
    DUF3498; Domain of unknown function (DUF3498)

  17. XM_006524244.5 → XP_006524307.1  ras/Rap GTPase-activating protein SynGAP isoform X13

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:135 → 297
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:288 → 611
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:5 → 196
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:601 → 1175
    DUF3498; Domain of unknown function (DUF3498)

  18. XM_036160600.1 → XP_036016493.1  ras/Rap GTPase-activating protein SynGAP isoform X16

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:135 → 297
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:288 → 611
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:5 → 196
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:601 → 1161
    DUF3498; Domain of unknown function (DUF3498)

  19. XM_006524242.3 → XP_006524305.1  ras/Rap GTPase-activating protein SynGAP isoform X10

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:166 → 328
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:319 → 642
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:36 → 227
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:632 → 1206
    DUF3498; Domain of unknown function (DUF3498)

  20. XM_030249785.2 → XP_030105645.1  ras/Rap GTPase-activating protein SynGAP isoform X11

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:166 → 328
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:319 → 642
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:36 → 227
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:632 → 1192
    DUF3498; Domain of unknown function (DUF3498)

  21. XM_036160598.1 → XP_036016491.1  ras/Rap GTPase-activating protein SynGAP isoform X13

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:135 → 297
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:288 → 611
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:5 → 196
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:601 → 1175
    DUF3498; Domain of unknown function (DUF3498)

  22. XM_006524239.5 → XP_006524302.1  ras/Rap GTPase-activating protein SynGAP isoform X6

    UniProtKB/TrEMBL
    A0A2R8VH83
    Conserved Domains (4) summary
    cd04013
    Location:193 → 355
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:346 → 669
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:63 → 254
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:659 → 1233
    DUF3498; Domain of unknown function (DUF3498)

  23. XM_036160601.1 → XP_036016494.1  ras/Rap GTPase-activating protein SynGAP isoform X19

    Conserved Domains (2) summary
    pfam12004
    Location:116 → 691
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1 → 126
    RasGAP; Ras GTPase Activating Domain

  24. XM_030249790.1 → XP_030105650.1  ras/Rap GTPase-activating protein SynGAP isoform X20

    Conserved Domains (2) summary
    pfam12004
    Location:116 → 689
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1 → 126
    RasGAP; Ras GTPase Activating Domain

  25. XM_006524248.3 → XP_006524311.1  ras/Rap GTPase-activating protein SynGAP isoform X17

    Conserved Domains (2) summary
    pfam12004
    Location:116 → 690
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1 → 126
    RasGAP; Ras GTPase Activating Domain

  26. XM_030249788.2 → XP_030105648.1  ras/Rap GTPase-activating protein SynGAP isoform X18

    Conserved Domains (2) summary
    pfam12004
    Location:116 → 676
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1 → 126
    RasGAP; Ras GTPase Activating Domain

RNA

  1. XR_003952116.1 RNA Sequence

  2. XR_003952115.1 RNA Sequence

  3. XR_385324.4 RNA Sequence

  4. XR_003952117.1 RNA Sequence

  5. XR_004939524.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F6SEU4.2 GenPept UniProtKB/Swiss-Prot:F6SEU4

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