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MCRS1 microspherule protein 1 [ Homo sapiens (human) ]

Gene ID: 10445, updated on 4-Jan-2025

Summary

Official Symbol
MCRS1provided by HGNC
Official Full Name
microspherule protein 1provided by HGNC
Primary source
HGNC:HGNC:6960
See related
Ensembl:ENSG00000187778 MIM:609504; AllianceGenome:HGNC:6960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P78; MCRS2; MSP58; INO80Q; ICP22BP
Summary
Enables RNA binding activity and telomerase inhibitor activity. Involved in several processes, including chromatin remodeling; positive regulation of protein localization to nucleolus; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm; nucleolus; and nucleoplasm. Part of Ino80 complex; MLL1 complex; and NSL complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in heart (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See MCRS1 in Genome Data Viewer
Location:
12q13.12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49558299..49568142, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (49520555..49530398, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49952082..49961925, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated serine rich 2 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 14813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49846952-49847452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49873095-49873682 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49907610-49907788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49932121-49932932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49932933-49933742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6316 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:49936243-49937442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49941330-49942138 Neighboring gene uncharacterized LOC105369761 Neighboring gene potassium voltage-gated channel subfamily H member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49961221-49962024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6319 Neighboring gene family with sequence similarity 186 member B Neighboring gene RNA, U6 small nuclear 834, pseudogene Neighboring gene RNA polymerase II subunit K pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ41193, FLJ98622

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA recombination  
involved_in DNA repair  
involved_in chromatin remodeling PubMed 
involved_in negative regulation of telomere maintenance via telomere lengthening PubMed 
involved_in positive regulation of DNA repair  
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of protein localization to nucleolus PubMed 
involved_in positive regulation of telomere maintenance in response to DNA damage  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in protein modification process PubMed 
involved_in regulation of DNA repair  
involved_in regulation of DNA replication PubMed 
involved_in regulation of DNA strand elongation PubMed 
involved_in regulation of cell cycle PubMed 
involved_in regulation of chromosome organization PubMed 
involved_in regulation of embryonic development  
involved_in telomere maintenance  
Component Evidence Code Pubs
part_of Ino80 complex PubMed 
part_of MLL1 complex PubMed 
part_of NSL complex  
part_of NSL complex PubMed 
located_in cytoplasm PubMed 
located_in dendrite  
part_of histone acetyltransferase complex PubMed 
located_in nucleolus PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in perikaryon  

General protein information

Preferred Names
microspherule protein 1
Names
58 kDa microspherule protein
INO80 complex subunit J
INO80 complex subunit Q
cell cycle-regulated factor (78 kDa)
cell cycle-regulated factor p78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012300.1NP_001012300.1  microspherule protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001012300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AY336730, BC011794
    Consensus CDS
    CCDS31795.1
    UniProtKB/Swiss-Prot
    Q96EZ8
    Related
    ENSP00000349640.4, ENST00000357123.8
    Conserved Domains (2) summary
    cd00060
    Location:358458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:147344
    MCRS_N; N-terminal region of micro-spherule protein
  2. NM_001278341.2NP_001265270.1  microspherule protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001265270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant 2. The resulting isoform (3) has a shorter N-terminus, compared to isoform 2.
    Source sequence(s)
    BC011794, BX538079, HY078747, R66413
    Consensus CDS
    CCDS61118.1
    Related
    ENSP00000444982.1, ENST00000546244.5
    Conserved Domains (2) summary
    cd00060
    Location:154254
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:1140
    MCRS_N; N-terminal region of micro-spherule protein
  3. NM_006337.5NP_006328.2  microspherule protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006328.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' coding sequence, compared to variant 2. The resulting isoform (1) is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    BC011794, HY078747, R66413
    Consensus CDS
    CCDS8787.1
    UniProtKB/Swiss-Prot
    O14742, O75497, Q6VN53, Q7Z372, Q96EZ8
    Related
    ENSP00000345358.4, ENST00000343810.9
    Conserved Domains (2) summary
    cd00060
    Location:345445
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:134331
    MCRS_N; N-terminal region of micro-spherule protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    49558299..49568142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537760.4XP_011536062.2  microspherule protein 1 isoform X1

  2. XM_005268572.3XP_005268629.1  microspherule protein 1 isoform X3

    See identical proteins and their annotated locations for XP_005268629.1

    UniProtKB/Swiss-Prot
    O14742, O75497, Q6VN53, Q7Z372, Q96EZ8
    Related
    ENSP00000448056.1, ENST00000550165.5
    Conserved Domains (2) summary
    cd00060
    Location:345445
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:134331
    MCRS_N; N-terminal region of micro-spherule protein
  3. XM_017018690.2XP_016874179.1  microspherule protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q96EZ8
    Related
    ENST00000551625.5
    Conserved Domains (2) summary
    cd00060
    Location:358458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:147344
    MCRS_N; N-terminal region of micro-spherule protein
  4. XM_047428083.1XP_047284039.1  microspherule protein 1 isoform X4

    UniProtKB/TrEMBL
    F8W126
    Related
    ENSP00000447514.1, ENST00000553173.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    49520555..49530398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370773.1XP_054226748.1  microspherule protein 1 isoform X1

  2. XM_054370775.1XP_054226750.1  microspherule protein 1 isoform X3

    UniProtKB/Swiss-Prot
    O14742, O75497, Q6VN53, Q7Z372, Q96EZ8
  3. XM_054370774.1XP_054226749.1  microspherule protein 1 isoform X2

  4. XM_054370776.1XP_054226751.1  microspherule protein 1 isoform X4

    UniProtKB/TrEMBL
    F8W126
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