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MTG1 mitochondrial ribosome associated GTPase 1 [ Homo sapiens (human) ]

Gene ID: 92170, updated on 4-Jan-2025

Summary

Official Symbol
MTG1provided by HGNC
Official Full Name
mitochondrial ribosome associated GTPase 1provided by HGNC
Primary source
HGNC:HGNC:32159
See related
Ensembl:ENSG00000148824 AllianceGenome:HGNC:32159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTP; GTPBP7
Summary
Enables GTPase activity. Involved in regulation of mitochondrial translation and regulation of respiratory system process. Located in mitochondrial inner membrane; mitochondrial ribosome; and nucleoplasm. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis (RPKM 19.8), duodenum (RPKM 18.8) and 25 other tissues See more
Orthologs
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Genomic context

See MTG1 in Genome Data Viewer
Location:
10q26.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133394157..133422520)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134349129..134377446)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135207661..135236024)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902563 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135191859-135192358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2979 Neighboring gene polyamine oxidase Neighboring gene ReSE screen-validated silencer GRCh37_chr10:135202015-135202172 Neighboring gene Sharpr-MPRA regulatory region 11835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135208387-135209341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135236507-135237126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135237945-135238452 Neighboring gene uncharacterized LOC124902564 Neighboring gene shadow of prion protein Neighboring gene olfactory receptor family 6 subfamily L member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Potential readthrough

Included gene: PAOX

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding  
enables GTPase activity  
enables GTPase activity PubMed 
enables protein binding PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane PubMed 
located_in mitochondrial matrix PubMed 
located_in mitochondrial ribosome PubMed 
located_in mitochondrion PubMed 
is_active_in mitochondrion  
located_in mitochondrion  
located_in nucleoplasm  

General protein information

Preferred Names
mitochondrial ribosome-associated GTPase 1
Names
GTP-binding protein 7 (putative)
mitochondrial GTPase 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138384.4NP_612393.2  mitochondrial ribosome-associated GTPase 1

    See identical proteins and their annotated locations for NP_612393.2

    Status: VALIDATED

    Source sequence(s)
    AI344070, AL161645, AL360181
    Consensus CDS
    CCDS31320.1
    UniProtKB/Swiss-Prot
    Q5VWX8, Q6PIY9, Q8IYJ4, Q8NC48, Q9BT17, Q9BVU8
    UniProtKB/TrEMBL
    A8K900
    Related
    ENSP00000323047.6, ENST00000317502.11
    Conserved Domains (1) summary
    cd01856
    Location:30207
    YlqF; Circularly permuted YlqF GTPase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133394157..133422520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134349129..134377446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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