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ERICH1 glutamate rich 1 [ Homo sapiens (human) ]

Gene ID: 157697, updated on 27-Nov-2024

Summary

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Official Symbol
ERICH1provided by HGNC
Official Full Name
glutamate rich 1provided by HGNC
Primary source
HGNC:HGNC:27234
See related
Ensembl:ENSG00000104714 AllianceGenome:HGNC:27234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC319
Expression
Ubiquitous expression in lymph node (RPKM 1.3), skin (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

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See ERICH1 in Genome Data Viewer
Location:
8p23.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (614746..731224, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (412067..522796, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (564746..681224, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18878 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429047-429548 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429549-430048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:436623-437436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:437437-438248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:452724-453298 Neighboring gene F-box protein 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:482877-483378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:486704-487214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:487215-487724 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:495813-496313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527413-527914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527915-528414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:563312-563864 Neighboring gene uncharacterized LOC124902055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:579043-579586 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:580473-581672 Neighboring gene testis development related protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:601645-602146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:602147-602646 Neighboring gene uncharacterized LOC124902053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:612449-612950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26945 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:637679-638333 Neighboring gene uncharacterized LOC124902054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:647979-648498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:669760-670295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:670296-670830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:677860-678646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:678707-679211 Neighboring gene uncharacterized LOC124902044 Neighboring gene uncharacterized LOC401442 Neighboring gene DLG associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Hou P, et al. Cancer Res, 2017 Aug 15. PMID 28625976, Free PMC Article
  2. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Elzi DJ, et al. J Proteome Res, 2014 Aug 1. PMID 24999758, Free PMC Article
  3. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
  4. An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Zhang Y, et al. Cell Chem Biol, 2022 Jan 20. PMID 34672954, Free PMC Article
  5. Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB. Li FL, et al. EMBO J, 2022 Sep 1. PMID 35844135, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00290

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
glutamate-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303100.2 → NP_001290029.1  glutamate-rich protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001290029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC090691, AK125470, AK297476, BU540397, CA433484, CN353744
    UniProtKB/TrEMBL
    B4DMI5
    Conserved Domains (1) summary
    COG5271
    Location:193 → 330
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  2. NM_207332.3 → NP_997215.1  glutamate-rich protein 1 isoform 1

    See identical proteins and their annotated locations for NP_997215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC046243, CN353744
    Consensus CDS
    CCDS5955.1
    UniProtKB/Swiss-Prot
    A8K2J9, Q86X53, Q9P063
    Related
    ENSP00000262109.7, ENST00000262109.8
    Conserved Domains (1) summary
    COG5271
    Location:193 → 330
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_156467.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC046243, BU540397, CN353744

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    614746..731224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421403.1 → XP_047277359.1  glutamate-rich protein 1 isoform X13

  2. XM_047421399.1 → XP_047277355.1  glutamate-rich protein 1 isoform X9

  3. XM_047421395.1 → XP_047277351.1  glutamate-rich protein 1 isoform X4

  4. XM_006716234.5 → XP_006716297.2  glutamate-rich protein 1 isoform X2

    Conserved Domains (2) summary
    pfam05285
    Location:271 → 337
    SDA1; SDA1
    cl22451
    Location:193 → 313
    ASF1_hist_chap; ASF1 like histone chaperone

  5. XM_047421393.1 → XP_047277349.1  glutamate-rich protein 1 isoform X1

  6. XM_047421396.1 → XP_047277352.1  glutamate-rich protein 1 isoform X5

  7. XM_047421394.1 → XP_047277350.1  glutamate-rich protein 1 isoform X3

  8. XM_047421398.1 → XP_047277354.1  glutamate-rich protein 1 isoform X8

  9. XM_047421404.1 → XP_047277360.1  glutamate-rich protein 1 isoform X14

  10. XM_047421400.1 → XP_047277356.1  glutamate-rich protein 1 isoform X10

  11. XM_047421402.1 → XP_047277358.1  glutamate-rich protein 1 isoform X12

  12. XM_047421397.1 → XP_047277353.1  glutamate-rich protein 1 isoform X6

  13. XM_047421401.1 → XP_047277357.1  glutamate-rich protein 1 isoform X11

  14. XM_011534731.4 → XP_011533033.1  glutamate-rich protein 1 isoform X7

    Conserved Domains (1) summary
    pfam05285
    Location:271 → 332
    SDA1; SDA1

  15. XM_017013133.3 → XP_016868622.1  glutamate-rich protein 1 isoform X15

    Conserved Domains (1) summary
    COG5271
    Location:193 → 330
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_007060715.1 RNA Sequence

  2. XR_007060714.1 RNA Sequence

  3. XR_007060710.1 RNA Sequence

  4. XR_007060711.1 RNA Sequence

  5. XR_007060707.1 RNA Sequence

  6. XR_007060706.1 RNA Sequence

  7. XR_007060709.1 RNA Sequence

  8. XR_007060708.1 RNA Sequence

  9. XR_007060713.1 RNA Sequence

  10. XR_007060716.1 RNA Sequence

  11. XR_007060712.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187572.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    4950..12826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007068638.1 RNA Sequence

  2. XR_951758.3 RNA Sequence

  3. XR_007068636.1 RNA Sequence

  4. XR_007068637.1 RNA Sequence

  5. XR_007068635.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    412067..522796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359837.1 → XP_054215812.1  glutamate-rich protein 1 isoform X13

  2. XM_054359842.1 → XP_054215817.1  glutamate-rich protein 1 isoform X19

  3. XM_054359841.1 → XP_054215816.1  glutamate-rich protein 1 isoform X19

  4. XM_054359834.1 → XP_054215809.1  glutamate-rich protein 1 isoform X17

  5. XM_054359835.1 → XP_054215810.1  glutamate-rich protein 1 isoform X17

  6. XM_054359832.1 → XP_054215807.1  glutamate-rich protein 1 isoform X9

  7. XM_054359827.1 → XP_054215802.1  glutamate-rich protein 1 isoform X4

  8. XM_054359825.1 → XP_054215800.1  glutamate-rich protein 1 isoform X16

  9. XM_054359824.1 → XP_054215799.1  glutamate-rich protein 1 isoform X2

  10. XM_054359823.1 → XP_054215798.1  glutamate-rich protein 1 isoform X1

  11. XM_054359822.1 → XP_054215797.1  glutamate-rich protein 1 isoform X1

  12. XM_054359828.1 → XP_054215803.1  glutamate-rich protein 1 isoform X5

  13. XM_054359826.1 → XP_054215801.1  glutamate-rich protein 1 isoform X3

  14. XM_054359830.1 → XP_054215805.1  glutamate-rich protein 1 isoform X6

  15. XM_054359833.1 → XP_054215808.1  glutamate-rich protein 1 isoform X10

  16. XM_054359838.1 → XP_054215813.1  glutamate-rich protein 1 isoform X14

  17. XM_054359836.1 → XP_054215811.1  glutamate-rich protein 1 isoform X12

  18. XM_054359829.1 → XP_054215804.1  glutamate-rich protein 1 isoform X6

  19. XM_054359831.1 → XP_054215806.1  glutamate-rich protein 1 isoform X7

  20. XM_054359840.1 → XP_054215815.1  glutamate-rich protein 1 isoform X18

  21. XM_054359844.1 → XP_054215819.1  glutamate-rich protein 1 isoform X15

  22. XM_054359843.1 → XP_054215818.1  glutamate-rich protein 1 isoform X20

  23. XM_054359839.1 → XP_054215814.1  glutamate-rich protein 1 isoform X18

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86X53.1 GenPept UniProtKB/Swiss-Prot:Q86X53

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