U.S. flag

An official website of the United States government

Mink1 misshapen-like kinase 1 (zebrafish) [ Mus musculus (house mouse) ]

Gene ID: 50932, updated on 4-Jan-2025

Summary

Official Symbol
Mink1provided by MGI
Official Full Name
misshapen-like kinase 1 (zebrafish)provided by MGI
Primary source
MGI:MGI:1355329
See related
Ensembl:ENSMUSG00000020827 AllianceGenome:MGI:1355329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B55; MINK; Ysk2; Map4k6
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in brain development; positive regulation of MAPK cascade; and protein phosphorylation. Acts upstream of or within negative thymic T cell selection. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in knee joint primordium; knee mesenchyme; lower leg mesenchyme; tibia; and tibia cartilage condensation. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in cortex adult (RPKM 44.5), frontal lobe adult (RPKM 42.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mink1 in Genome Data Viewer
Location:
11 B3; 11 43.0 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70452272..70505309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70561580..70614482)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40193 Neighboring gene phospholipase D2 Neighboring gene STARR-seq mESC enhancer starr_29877 Neighboring gene predicted gene, 51905 Neighboring gene RIKEN cDNA 4930544D05 gene Neighboring gene cholinergic receptor, nicotinic, epsilon polypeptide Neighboring gene predicted gene 12315

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding PubMed 
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in actin cytoskeleton organization  
involved_in actin cytoskeleton organization  
involved_in brain development PubMed 
involved_in chemical synaptic transmission  
involved_in chemical synaptic transmission  
involved_in chromatin remodeling  
involved_in dendrite morphogenesis  
involved_in dendrite morphogenesis  
acts_upstream_of_or_within negative thymic T cell selection PubMed 
involved_in neuron cellular homeostasis  
involved_in neuron projection morphogenesis  
involved_in positive regulation of JNK cascade PubMed 
involved_in positive regulation of JNK cascade  
involved_in positive regulation of p38MAPK cascade PubMed 
involved_in protein autophosphorylation  
involved_in protein autophosphorylation  
involved_in protein phosphorylation PubMed 
involved_in protein phosphorylation  
involved_in regulation of AMPA receptor activity  
involved_in regulation of MAPK cascade  
involved_in regulation of cell migration  
involved_in regulation of cell-cell adhesion  
involved_in regulation of cell-matrix adhesion  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in axon  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in dendrite  
located_in postsynaptic density  

General protein information

Preferred Names
misshapen-like kinase 1
Names
GCK family kinase MiNK
MAPK/ERK kinase kinase kinase 6
MEK kinase kinase 6
MEKKK 6
Misshapen/NIKs-related kinase
Yeast Sps1/Ste20-related kinase 2
misshapen/NIK-related kinase
NP_001039424.1
NP_001039429.1
NP_001390484.1
NP_001390485.1
NP_001390486.1
NP_057922.2
NP_795712.2
XP_006533740.1
XP_006533741.1
XP_017170134.1
XP_017170135.1
XP_030101977.1
XP_030101978.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045959.2NP_001039424.1  misshapen-like kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL592547
    Consensus CDS
    CCDS36205.1
    UniProtKB/TrEMBL
    Q5SXG1, Q5SXG3
    Related
    ENSMUSP00000072649.8, ENSMUST00000072873.14
    Conserved Domains (3) summary
    smart00036
    Location:10191317
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  2. NM_001045964.2NP_001039429.1  misshapen-like kinase 1 isoform 4

    See identical proteins and their annotated locations for NP_001039429.1

    Status: VALIDATED

    Source sequence(s)
    AL592547
    Consensus CDS
    CCDS48837.1
    UniProtKB/TrEMBL
    G3X9G2, Q5SXG1
    Related
    ENSMUSP00000072091.7, ENSMUST00000072237.13
    Conserved Domains (3) summary
    smart00036
    Location:10261324
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  3. NM_001403555.1NP_001390484.1  misshapen-like kinase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL592547
    UniProtKB/TrEMBL
    Q5SXG1
  4. NM_001403556.1NP_001390485.1  misshapen-like kinase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL592547
    UniProtKB/TrEMBL
    Q5SXG1
  5. NM_001403557.1NP_001390486.1  misshapen-like kinase 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL592547
    UniProtKB/TrEMBL
    Q5SXG1
  6. NM_016713.3NP_057922.2  misshapen-like kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_057922.2

    Status: VALIDATED

    Source sequence(s)
    AL592547
    Consensus CDS
    CCDS24954.1
    UniProtKB/TrEMBL
    Q5SXG1
    Related
    ENSMUSP00000099618.5, ENSMUST00000102558.11
    Conserved Domains (3) summary
    smart00036
    Location:9821280
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  7. NM_176893.3NP_795712.2  misshapen-like kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_795712.2

    Status: VALIDATED

    Source sequence(s)
    AL592547
    Consensus CDS
    CCDS24955.1
    UniProtKB/Swiss-Prot
    Q5SXG2, Q921M6, Q9JM52, Q9JM92
    UniProtKB/TrEMBL
    Q5SXG1
    Related
    ENSMUSP00000099619.5, ENSMUST00000102559.11
    Conserved Domains (3) summary
    smart00036
    Location:9901288
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70452272..70505309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533677.4XP_006533740.1  misshapen-like kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006533740.1

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (3) summary
    smart00036
    Location:10561354
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    PHA03307
    Location:539835
    PHA03307; transcriptional regulator ICP4; Provisional
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  2. XM_006533678.4XP_006533741.1  misshapen-like kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_006533741.1

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (3) summary
    smart00036
    Location:10551353
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    PHA03307
    Location:539835
    PHA03307; transcriptional regulator ICP4; Provisional
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  3. XM_017314645.3XP_017170134.1  misshapen-like kinase 1 isoform X6

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (2) summary
    smart00036
    Location:10181316
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  4. XM_017314646.3XP_017170135.1  misshapen-like kinase 1 isoform X7

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (2) summary
    smart00036
    Location:10111309
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  5. XM_030246117.2XP_030101977.1  misshapen-like kinase 1 isoform X8

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (3) summary
    smart00036
    Location:9811279
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    PHA03307
    Location:515788
    PHA03307; transcriptional regulator ICP4; Provisional
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  6. XM_030246118.1XP_030101978.1  misshapen-like kinase 1 isoform X9

    UniProtKB/TrEMBL
    F7AMS7
    Conserved Domains (2) summary
    smart00036
    Location:7451043
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    PHA03307
    Location:228524
    PHA03307; transcriptional regulator ICP4; Provisional

RNA

  1. XR_388490.5 RNA Sequence

External link. Please review our privacy policy.