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    cv-c crossveinless c [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41749, updated on 4-Jan-2025

    Summary

    Official Symbol
    cv-cprovided by FlyBase
    Official Full Name
    crossveinless cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285955
    Locus tag
    Dmel_CG34389
    See related
    AllianceGenome:FB:FBgn0285955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14845; CG14846; CG14847; CG14848; CG14849; CG31319; CG31330; CG34389; CG8480; Cv-c; Dmel\CG34389; l(3)06951; rhoGAP88C; RhoGAP88C
    Old locus tag
    CG14846; CG14847; CG31319; CG31330; Dmel_CG14846; Dmel_CG14847; Dmel_CG31319; Dmel_CG31330
    Summary
    Enables GTPase activator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and open tracheal system development. Located in basolateral plasma membrane. Is expressed in several structures, including brain; fan-shaped body; imaginal disc; large field neurons; and wing vein. Used to study gonadal dysgenesis. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); STARD13 (StAR related lipid transfer domain containing 13); and STARD8 (StAR related lipid transfer domain containing 8). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See cv-c in Genome Data Viewer
    Location:
    88B8-88C2; 3-55 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14391683..14481713, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10217405..10307435, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44943 Neighboring gene scotti Neighboring gene mir-2281 stem loop Neighboring gene antisense RNA:CR44176 Neighboring gene natalisin Neighboring gene long non-coding RNA:CR44177 Neighboring gene HTRA2-related serine protease

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity PubMed 
    enables GTPase activator activity PubMed 
    enables lipid binding  
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis PubMed 
    involved_in Rho protein signal transduction PubMed 
    involved_in actin cytoskeleton organization  
    involved_in assembly of actomyosin apparatus involved in cytokinesis PubMed 
    involved_in cell morphogenesis PubMed 
    involved_in cortical actin cytoskeleton organization PubMed 
    involved_in dorsal closure PubMed 
    involved_in establishment of mitotic spindle orientation PubMed 
    involved_in head involution PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis PubMed 
    involved_in maintenance of epithelial integrity, open tracheal system PubMed 
    involved_in metaphase/anaphase transition of mitotic cell cycle PubMed 
    involved_in midgut development PubMed 
    involved_in mitotic spindle organization PubMed 
    involved_in negative regulation of Rho protein signal transduction PubMed 
    involved_in neuromuscular synaptic transmission PubMed 
    involved_in open tracheal system development PubMed 
    involved_in positive regulation of synaptic transmission PubMed 
    involved_in regulation of Rho protein signal transduction  
    involved_in regulation of dendrite morphogenesis PubMed 
    involved_in signal transduction  
    involved_in sleep PubMed 
    involved_in spindle localization PubMed 
    involved_in spiracle morphogenesis, open tracheal system PubMed 
    involved_in tracheal pit formation in open tracheal system PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane PubMed 
    located_in cell cortex PubMed 

    General protein information

    Preferred Names
    crossveinless c
    Names
    CG34389-PA
    CG34389-PC
    CG34389-PD
    crossveinless-c
    cv-c-PA
    cv-c-PC
    cv-c-PD
    lethal (3) 06951

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14391683..14481713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104318.2 → NP_001097788.1  crossveinless c, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR05, A8WHF8
      Conserved Domains (3) summary
      cd09538
      Location:1382 → 1441
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cd04375
      Location:1893 → 2116
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
      cl14643
      Location:2148 → 2343
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    2. NM_001104316.2 → NP_001097786.1  crossveinless c, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR05, A8WHF8
      Conserved Domains (3) summary
      cd09538
      Location:1382 → 1441
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cd04375
      Location:1893 → 2116
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
      cl14643
      Location:2148 → 2343
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    3. NM_169583.3 → NP_731907.1  crossveinless c, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY28, Q9VFK2
      Related
      FBpp0111543
      Conserved Domains (3) summary
      cd09538
      Location:48 → 107
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cd04375
      Location:559 → 782
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
      cl14643
      Location:814 → 1009
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
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