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St3 Sulfotransferase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37743, updated on 4-Jan-2025

Summary

Official Symbol
St3provided by FlyBase
Official Full Name
Sulfotransferase 3provided by FlyBase
Primary source
FLYBASE:FBgn0265052
Locus tag
Dmel_CG44167
See related
AllianceGenome:FB:FBgn0265052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11293; CG44167; CG5431; Dmel\CG44167; dmST3; st3
Old locus tag
Dmel_CG11293; Dmel_CG5431
Summary
Enables sulfotransferase activity. Involved in defense response to bacterium; sulfation; and xenobiotic metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic Malpighian tubule; embryonic esophagus; and embryonic proventriculus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital ichthyosis 14; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See St3 in Genome Data Viewer
Location:
59F6-59F6; 2-104 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23683377..23687980)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19570900..19575503)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphodiesterase 8 Neighboring gene Sulfotransferase 1 Neighboring gene lethal (2) essential for life Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2 Neighboring gene uncharacterized protein Neighboring gene angel

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sulfotransferase activity  
enables sulfotransferase activity PubMed 
enables sulfotransferase activity  
Process Evidence Code Pubs
involved_in defense response to bacterium PubMed 
involved_in sulfation  
involved_in sulfation PubMed 
involved_in xenobiotic metabolic process PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytosol PubMed 

General protein information

Preferred Names
sulfotransferase 3
Names
CG44167-PA
CG44167-PB
CG44167-PC
St3-PA
St3-PB
St3-PC
NP_001137744.1
NP_001261155.1
NP_611816.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23683377..23687980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274226.1 → NP_001261155.1  sulfotransferase 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261155.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF40
    Conserved Domains (1) summary
    pfam00685
    Location:45 → 301
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_137972.4 → NP_611816.2  sulfotransferase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611816.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL86, Q9W1L7
    Related
    FBpp0307659
    Conserved Domains (1) summary
    pfam00685
    Location:45 → 301
    Sulfotransfer_1; Sulfotransferase domain
  3. NM_001144272.3 → NP_001137744.1  sulfotransferase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZP4, Q6NL86
    Conserved Domains (1) summary
    pfam00685
    Location:45 → 301
    Sulfotransfer_1; Sulfotransferase domain
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