ftz-f1 ftz transcription factor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ftz-f1provided by FlyBase
Official Full Name: ftz transcription factor 1provided by FlyBase
Primary source: FLYBASE:FBgn0001078
Locus tag: Dmel_CG4059
See related: AllianceGenome:FB:FBgn0001078
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alphaftz-f1; alphaFTZ-F1; alphaFTZF1; beta Ftz-f1; beta FTZ-F1; beta-Ftz-F1; beta-FTZ-F1; betaftz-f1; betaftz-F1; betaFtz-f1; betaFtz-F1; betaFTZ-F1; betaftzf1; betaFTZF1; bFTZ-F1; BFTZ-F1; CG13378; CG4059; DEP1; dFtz-F1alpha; dFTZ-F1alpha; Dmel\CG4059; dmFTZ-f1; DmFTZ-F1; FIP1; ftz-F1; Ftz-f1; Ftz-F1; FTZ-F1; FTZ-F1A; ftz-f1alpha; FTZ-F1alpha; FTZ-Fl; ftzf1; ftzF1; Ftzf1; FTZF1; FTZf1alpha; ftz_f1; l(3)03649; NR5A3
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including instar larval or pupal development; juvenile hormone mediated signaling pathway; and nervous system development. Located in nucleus. Is expressed in several structures, including appendage; follicle cell; gland; gut section; and ring gland. Human ortholog(s) of this gene implicated in 46,XX sex reversal 4; 46,XY sex reversal 3; Zellweger syndrome; primary ovarian insufficiency 7; and spermatogenic failure 8. Orthologous to several human genes including NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 75D8-75E1; 3-45 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (18750607..18801309, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (18743707..18794409, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Domain analysis of Drosophila Blimp-1 reveals the importance of its repression function and instability in determining pupation timing.
Title: Domain analysis of Drosophila Blimp-1 reveals the importance of its repression function and instability in determining pupation timing.
The intrinsically disordered region of GCE protein adopts a more fixed structure by interacting with the LBD of the nuclear receptor FTZ-F1.
Title: The intrinsically disordered region of GCE protein adopts a more fixed structure by interacting with the LBD of the nuclear receptor FTZ-F1.
MLE Helicase Is a New Participant in the Transcription Regulation of the ftz-f1 Gene Encoding Nuclear Receptor in Higher Eukaryotes.
Title: MLE Helicase Is a New Participant in the Transcription Regulation of the ftz-f1 Gene Encoding Nuclear Receptor in Higher Eukaryotes.
Orphan nuclear receptor ftz-f1 (NR5A3) promotes egg chamber survival in the Drosophila ovary.
Title: Orphan nuclear receptor ftz-f1 (NR5A3) promotes egg chamber survival in the Drosophila ovary.
Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim.
Title: Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim.
We identify the conserved transcription factors Sox box protein 15 (Sox15) and Ftz transcription factor 1 (Ftz-f1) as genes controlled by dTcf/Pan involved in tumor development. In conclusion, this study reports a role for dTcf/Pan as a repressor of normal and oncogenic growth and identifies the genes inducing tumorigenesis downstream of dTcf/Pan.
Title: dTcf/Pangolin suppresses growth and tumor formation in Drosophila.
the alpha6 helix is dynamic in solution when Ftz-F1 is bound to the LxxLL motif of its cofactor Ftz, undergoing motions on the fast (picosecond to nanosecond) as well as slow (microsecond to millisecond) time scales.
Title: Solution Nuclear Magnetic Resonance Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveal a Dynamic Helix in the Ligand-Binding Pocket.
The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
Title: A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster.
a novel ecdysone-dependent enhancer in the intron of ftz-f1 gene
Title: Studying a novel ecdysone-dependent enhancer.
Comparative analysis of enhancers containing Ftz/Ftz-F1 binding sites that were or were not bona fide targets in vivo suggested that GAF negatively regulates enhancers that contain Ftz/Ftz-F1 binding sites but are not actually utilized.
Title: Activation of Ftz-F1-Responsive Genes through Ftz/Ftz-F1 Dependent Enhancers.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2066 (e-PCR)
- UniSTS:21535

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c18781086-18772464 mobile_element_type = transposon:roo{}1043

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval or pupal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in juvenile hormone mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	TAS Traceable Author Statement more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupariation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of development, heterochronic	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ecdysone	TAS Traceable Author Statement more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ftz transcription factor 1

Names: CG4059-PA; CG4059-PB; CG4059-PC; CG4059-PD; Ftz interacting protein 1; beta-Ftz transcription factor 1; betaftz-f1; ftz factor 1; ftz-f1-PA; ftz-f1-PB; ftz-f1-PC; ftz-f1-PD; ftz-transcription factor 1; fushi tarazu transcription factor 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

18750607..18801309 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259895.2 → NP_001246824.1 ftz transcription factor 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246824.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NFK2

Conserved Domains (2) summary

cd06944
Location:570 → 800

NR_LBD_Ftz-F1_like; The ligand binding domain of FTZ-F1 like nuclear receptors

cd07167
Location:284 → 376

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
NM_001316437.1 → NP_001303366.1 ftz transcription factor 1, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WH29

Conserved Domains (2) summary

cd06944
Location:620 → 850

NR_LBD_Ftz-F1_like; The ligand binding domain of FTZ-F1 like nuclear receptors

cd07167
Location:284 → 376

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
NM_079419.3 → NP_524143.2 ftz transcription factor 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524143.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B9EQU1, P33244, Q24538, Q8IQT5, Q960U2, Q9VVS8

Related

FBpp0074853

Conserved Domains (2) summary

cd06944
Location:794 → 1024

NR_LBD_Ftz-F1_like; The ligand binding domain of FTZ-F1 like nuclear receptors

cd07167
Location:508 → 600

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
NM_168775.2 → NP_730359.1 ftz transcription factor 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730359.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NFK2

Related

FBpp0074854

Conserved Domains (2) summary

cd06944
Location:570 → 800

NR_LBD_Ftz-F1_like; The ligand binding domain of FTZ-F1 like nuclear receptors

cd07167
Location:284 → 376

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers