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dx deltex [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31589, updated on 4-Jan-2025

Summary

Official Symbol
dxprovided by FlyBase
Official Full Name
deltexprovided by FlyBase
Primary source
FLYBASE:FBgn0000524
Locus tag
Dmel_CG3929
See related
AllianceGenome:FB:FBgn0000524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3929; Deltex; Dlx; DMDELTEX; Dmel\CG3929; Dx
Summary
Enables Notch binding activity and ubiquitin protein ligase activity. Involved in several processes, including Notch receptor processing; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytosol and nucleus. Is expressed in organism. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1); DTX2 (deltex E3 ubiquitin ligase 2); and DTX4 (deltex E3 ubiquitin ligase 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

Location:
6B1-6B2; 1-17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6533999..6538575)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6428032..6432608)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Alanine-glyoxylate aminotransferase Neighboring gene Ribosomal protein L7A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Notch binding PubMed 
enables ubiquitin protein ligase activity  
enables ubiquitin protein ligase activity PubMed 
enables zinc ion binding  
enables zinc ion binding PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing PubMed 
involved_in Notch signaling pathway  
involved_in Notch signaling pathway  
involved_in endocytosis PubMed 
involved_in negative regulation of Notch signaling pathway PubMed 
involved_in negative regulation of Notch signaling pathway PubMed 
involved_in negative regulation of Notch signaling pathway PubMed 
involved_in negative regulation of canonical Wnt signaling pathway PubMed 
involved_in positive regulation of Notch signaling pathway PubMed 
involved_in positive regulation of Notch signaling pathway PubMed 
involved_in positive regulation of Notch signaling pathway PubMed 
involved_in positive regulation of Notch signaling pathway PubMed 
involved_in positive regulation of Toll signaling pathway PubMed 
involved_in positive regulation of canonical Wnt signaling pathway PubMed 
involved_in positive regulation of endocytosis PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
involved_in protein ubiquitination  
involved_in protein ubiquitination PubMed 
involved_in protein ubiquitination  
involved_in wing disc development PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytosol PubMed 
is_active_in nucleoplasm  
located_in nucleus PubMed 

General protein information

Preferred Names
deltex
Names
CG3929-PA
dx-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6533999..6538575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078509.3 → NP_511064.2  deltex [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511064.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9YJA9, A9YJB1, A9YJB7, B3LF71, Q23985, Q86P53, Q9W3Z1
    Related
    FBpp0070876
    Conserved Domains (3) summary
    smart00678
    Location:133 → 209
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:609 → 735
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:548 → 600
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
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