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Lis-1 Lissencephaly-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36791, updated on 9-Dec-2024

Summary

Official Symbol
Lis-1provided by FlyBase
Official Full Name
Lissencephaly-1provided by FlyBase
Primary source
FLYBASE:FBgn0015754
Locus tag
Dmel_CG8440
See related
AllianceGenome:FB:FBgn0015754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8440; D-Lis1; Dlis-1; DLis-1; DLIS-1; dLis1; Dlis1; DLis1; DLIS1; Dmel\CG8440; DmLIS1; l(2)k13209; l(2R)W8; Lis; Lis 1; lis-1; LIS-1; lis1; Lis1; n(2)k11702
Summary
Enables dynein complex binding activity. Involved in several processes, including generation of neurons; oogenesis; and transport along microtubule. Located in several cellular components, including growth cone; microtubule cytoskeleton; and neuronal cell body. Part of dynactin complex and dynein complex. Colocalizes with kinetochore; kinetochore microtubule; and spindle pole centrosome. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval midgut primordium; ganglia; germline cell; and gut section. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Lis-1 in Genome Data Viewer
Location:
52F4-52F5; 2-78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16178826..16185103)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12066331..12072608)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Protein tyrosine phosphatase 52F Neighboring gene uncharacterized protein Neighboring gene clueless Neighboring gene calypso

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dynein complex binding  
enables dynein complex binding PubMed 
enables dynein complex binding PubMed 
enables microtubule plus-end binding  
Items 1 - 25 of 51
Process Evidence Code Pubs
involved_in axo-dendritic transport PubMed 
involved_in axonal transport PubMed 
involved_in border follicle cell migration PubMed 
involved_in brain morphogenesis  
involved_in centrosome localization PubMed 
involved_in centrosome separation PubMed 
involved_in chorion-containing eggshell pattern formation PubMed 
involved_in clathrin-dependent endocytosis involved in vitellogenesis PubMed 
involved_in dendrite development PubMed 
involved_in dendrite morphogenesis PubMed 
involved_in establishment of mitotic spindle orientation  
involved_in female germ-line cyst formation PubMed 
involved_in fusome organization PubMed 
involved_in germ cell development  
involved_in germarium-derived cystoblast division PubMed 
involved_in germarium-derived oocyte differentiation PubMed 
involved_in germarium-derived oocyte fate determination PubMed 
involved_in intracellular mRNA localization PubMed 
involved_in intracellular protein transport PubMed 
involved_in kinetochore organization PubMed 
involved_in microtubule organizing center organization  
involved_in muscle cell cellular homeostasis PubMed 
involved_in muscle cell cellular homeostasis PubMed 
involved_in mushroom body development PubMed 
involved_in neuroblast proliferation PubMed 
involved_in nuclear migration  
involved_in nuclear migration PubMed 
involved_in nuclear migration along microtubule PubMed 
involved_in nucleus localization PubMed 
involved_in oocyte fate determination PubMed 
involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification PubMed 
involved_in oogenesis PubMed 
involved_in ovarian fusome organization PubMed 
involved_in ovarian nurse cell to oocyte transport PubMed 
involved_in photoreceptor cell axon guidance PubMed 
involved_in positive regulation of BMP signaling pathway PubMed 
involved_in positive regulation of axonogenesis PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition PubMed 
involved_in protein localization PubMed 
involved_in protein localization PubMed 
involved_in protein localization to kinetochore PubMed 
involved_in regulation of dendrite morphogenesis PubMed 
involved_in retrograde axonal transport  
involved_in retrograde axonal transport PubMed 
involved_in rhabdomere development PubMed 
involved_in spermatogenesis PubMed 
involved_in spindle assembly PubMed 
involved_in stem cell population maintenance PubMed 
involved_in transport along microtubule PubMed 
involved_in vesicle transport along microtubule  
Items 1 - 25 of 51
Component Evidence Code Pubs
located_in axon PubMed 
located_in cell cortex PubMed 
located_in centrosome PubMed 
is_active_in cytoplasmic microtubule  
located_in dendrite PubMed 
part_of dynactin complex PubMed 
part_of dynein complex PubMed 
located_in growth cone PubMed 
colocalizes_with kinetochore PubMed 
located_in kinetochore PubMed 
colocalizes_with kinetochore microtubule PubMed 
part_of microtubule associated complex  
is_active_in neuron projection  
is_active_in neuronal cell body  
located_in neuronal cell body PubMed 
is_active_in nuclear envelope  
located_in spindle pole PubMed 
colocalizes_with spindle pole centrosome PubMed 

General protein information

Preferred Names
Lissencephaly-1
Names
CG8440-PA
CG8440-PB
CG8440-PF
CG8440-PG
Lis-1-PA
Lis-1-PB
Lis-1-PF
Lis-1-PG
Paf-AHbeta
lissencephaly-1
platelet-activating factor acetylhydrolase Ib beta-subunit homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16178826..16185103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057812.5 → NP_477160.1  Lissencephaly-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477160.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZJ3, O96698, Q5BI20, Q7KNS3, Q8SXJ6
    UniProtKB/TrEMBL
    A0A0B4K812
    Related
    FBpp0086375
    Conserved Domains (3) summary
    smart00667
    Location:9 → 40
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:100 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]
  2. NM_001259432.2 → NP_001246361.1  Lissencephaly-1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZJ3, O96698, Q5BI20, Q7KNS3, Q8SXJ6
    UniProtKB/TrEMBL
    A0A0B4K812
    Conserved Domains (3) summary
    smart00667
    Location:9 → 40
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:100 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]
  3. NM_176190.2 → NP_788370.1  Lissencephaly-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZJ3, O96698, Q5BI20, Q7KNS3, Q8SXJ6
    UniProtKB/TrEMBL
    A0A0B4K812
    Related
    FBpp0086379
    Conserved Domains (3) summary
    smart00667
    Location:9 → 40
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:100 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]
  4. NM_206130.2 → NP_995852.1  Lissencephaly-1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZJ3, O96698, Q5BI20, Q7KNS3, Q8SXJ6
    UniProtKB/TrEMBL
    A0A0B4K812
    Conserved Domains (3) summary
    smart00667
    Location:9 → 40
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:100 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]
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