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    add-1 Adducin-related protein 1;Class II aldolase/adducin N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180760, updated on 9-Dec-2024

    Summary

    Official Symbol
    add-1
    Official Full Name
    Adducin-related protein 1;Class II aldolase/adducin N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00000072
    Locus tag
    CELE_F39C12.2
    See related
    AllianceGenome:WB:WBGene00000072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Involved in actin filament bundle organization; memory; and receptor localization to synapse. Located in postsynaptic density. Is expressed in several structures, including coelomocyte; hypodermis; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; gastroschisis; and spastic quadriplegic cerebral palsy 3. Orthologous to human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See add-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (4854065..4860045, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CCDC22 N-terminal domain-containing protein Neighboring gene EGF-like domain-containing protein Neighboring gene GATOR2 complex protein MIO zinc-ribbon like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tetraspanin-14 Neighboring gene Nematocin

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding  
    enables actin filament binding  
    enables actin filament binding PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytoskeleton  
    located_in cytoskeleton  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density  
    located_in postsynaptic density PubMed 

    General protein information

    Preferred Names
    Adducin-related protein 1;Class II aldolase/adducin N-terminal domain-containing protein
    NP_001024639.1
    • Confirmed by transcript evidence
    NP_001024640.1
    • Confirmed by transcript evidence
    NP_001024641.1
    • Confirmed by transcript evidence
    NP_001024642.1
    • Confirmed by transcript evidence
    NP_001367832.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4854065..4860045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029469.5NP_001024640.1  Adducin-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44581, Q95X64, Q9U9J9, Q9U9K0
      Conserved Domains (1) summary
      cl00214
      Location:115360
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    2. NM_001029470.4NP_001024641.1  Adducin-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024641.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9K0
      Conserved Domains (1) summary
      cl00214
      Location:115360
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    3. NM_001029468.5NP_001024639.1  Adducin-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9K0
      Conserved Domains (1) summary
      cl00214
      Location:115360
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    4. NM_001029471.2NP_001024642.1  Adducin-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024642.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9K0
      Conserved Domains (1) summary
      cl00214
      Location:115360
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    5. NM_001380952.1NP_001367832.1  Class II aldolase/adducin N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JYB0
      Conserved Domains (1) summary
      cl00214
      Location:115360
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
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