prg-1 Piwi-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: prg-1
Official Full Name: Piwi-like protein 1
Primary source: WormBase:WBGene00004178
Locus tag: CELE_D2030.6
See related: AllianceGenome:WB:WBGene00004178
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables 21U-RNA binding activity. Involved in several processes, including 21U-RNA metabolic process; germ-line stem cell division; and positive regulation of mitotic nuclear division. Located in P granule. Is expressed in germ line and in male. Orthologous to several human genes including PIWIL1 (piwi like RNA-mediated gene silencing 1) and PIWIL3 (piwi like RNA-mediated gene silencing 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See prg-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (7585329..7588367, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility.
Title: Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility.
DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
Title: DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
Hermaphrodite Piwi-mutant worms (Prg-1-deficient) are almost sterile.
Title: Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants.
Piwi/PRG-1 Argonaute and TGF-beta Mediate Transgenerational Learned Pathogenic Avoidance.
Title: Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance.
Transgenerational sterility of prg-1 mutants is a form of adult reproductive diapause.
Title: Transgenerational Sterility of Piwi Mutants Represents a Dynamic Form of Adult Reproductive Diapause.
Study showed that two essential piRNA factors, PRDE-1 and PRG-1/PIWI, inhibit axon regeneration in a gonad-independent and cell-autonomous manner.
Title: A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans.
PRG-1 is involved in the regulation of nictation.
Title: The genetic basis of natural variation in a phoretic behavior.
PRG-1 is required continuously for germ cell immortality, suggesting that ultimately prg-1 is indispensable for silencing of some endogenous loci.
Title: Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants.
These results demonstrate that, at least in Caenorhabditis elegans, the Piwi pathway can impose a state of gene silencing that borders on 'permanently silent'.
Title: Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans.
Our data suggest that PRG-1 promotes expression, processing, or stability of 21U-RNAs, which, in turn or in concert with PRG-1, promote proper expression of spermatogenesis transcripts.
Title: A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2030.6 (e-PCR)
- UniSTS:309484

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 21U-RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables piRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 21U-RNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Piwi-like protein 1

NP_492121.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7585329..7588367 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059720.7 → NP_492121.1 Piwi-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492121.1

Status: REVIEWED

UniProtKB/TrEMBL

P90786

Conserved Domains (3) summary

smart00949
Location:218 → 354

PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille

cd04658
Location:341 → 807

Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...

pfam16486
Location:44 → 106

ArgoN; N-terminal domain of argonaute