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    Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 14719, updated on 4-Jan-2025

    Summary

    Official Symbol
    Got2provided by MGI
    Official Full Name
    glutamatic-oxaloacetic transaminase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:95792
    See related
    Ensembl:ENSMUSG00000031672 AllianceGenome:MGI:95792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Got-2; Kyat4; mAspAT; FABP-pm
    Summary
    Enables L-aspartate:2-oxoglutarate aminotransferase activity. Involved in malate-aspartate shuttle. Acts upstream of or within aspartate biosynthetic process; glutamate catabolic process to aspartate; and oxaloacetate metabolic process. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Used to study early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in heart adult (RPKM 277.4), liver adult (RPKM 151.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Got2 in Genome Data Viewer
    Location:
    8 D1; 8 47.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96590761..96615029, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95864133..95888401, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22403 Neighboring gene predicted gene, 31805 Neighboring gene solute carrier family 38, member 7 Neighboring gene STARR-positive B cell enhancer ABC_E2872 Neighboring gene predicted gene, 51586 Neighboring gene predicted gene 8637

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC102129, MGC115763

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-aspartate:2-oxoglutarate aminotransferase activity  
    enables L-aspartate:2-oxoglutarate aminotransferase activity PubMed 
    enables L-aspartate:2-oxoglutarate aminotransferase activity  
    enables L-aspartate:2-oxoglutarate aminotransferase activity  
    enables amino acid binding  
    enables carboxylic acid binding  
    enables enzyme binding  
    enables identical protein binding  
    enables kynurenine-oxoglutarate transaminase activity  
    enables phospholipid binding  
    enables pyridoxal phosphate binding  
    enables pyridoxal phosphate binding  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process  
    involved_in amino acid metabolic process  
    acts_upstream_of_or_within aspartate biosynthetic process PubMed 
    involved_in aspartate catabolic process  
    involved_in aspartate catabolic process  
    involved_in aspartate catabolic process  
    involved_in aspartate metabolic process  
    involved_in aspartate metabolic process  
    involved_in dicarboxylic acid metabolic process  
    involved_in fatty acid transport  
    acts_upstream_of_or_within glutamate catabolic process PubMed 
    acts_upstream_of_or_within glutamate catabolic process to aspartate PubMed 
    involved_in glutamate metabolic process  
    involved_in malate-aspartate shuttle PubMed 
    acts_upstream_of_or_within oxaloacetate metabolic process PubMed 
    involved_in oxaloacetate metabolic process  
    involved_in response to ethanol  
    involved_in response to ethanol  
    Component Evidence Code Pubs
    located_in T-tubule  
    located_in cell surface  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial matrix PubMed 
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    located_in myelin sheath PubMed 
    located_in perikaryon  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of protein-containing complex  
    located_in sarcolemma  

    General protein information

    Preferred Names
    aspartate aminotransferase, mitochondrial
    Names
    FABP-1
    FABPpm
    fatty acid-binding protein
    glutamate oxaloacetate transaminase 2, mitochondrial
    kynurenine aminotransferase 4
    kynurenine aminotransferase IV
    kynurenine--oxoglutarate transaminase 4
    kynurenine--oxoglutarate transaminase IV
    mitochondrial aspartate aminotransferase
    plasma membrane fatty acid binding protein
    plasma membrane-associated fatty acid-binding protein
    transaminase A
    NP_034455.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010325.3NP_034455.1  aspartate aminotransferase, mitochondrial

      See identical proteins and their annotated locations for NP_034455.1

      Status: VALIDATED

      Source sequence(s)
      AC127300
      Consensus CDS
      CCDS22568.1
      UniProtKB/Swiss-Prot
      O09188, P05202, Q3TIP6, Q3UD91, Q5HZH5
      Related
      ENSMUSP00000034097.8, ENSMUST00000034097.8
      Conserved Domains (2) summary
      PLN02397
      Location:32430
      PLN02397; aspartate transaminase
      pfam00155
      Location:57425
      Aminotran_1_2; Aminotransferase class I and II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96590761..96615029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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