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Conserved domains on  [gi|6754036|ref|NP_034455|]
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aspartate aminotransferase, mitochondrial [Mus musculus]

Protein Classification

aspartate aminotransferase( domain architecture ID 10791343)

aspartate aminotransferase catalyzes the conversion of 2-oxoglutarate and L-aspartate to L-glutamate and oxaloacetate and plays a major role in the metabolism of amino acids and organic acids related to the Krebs cycle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02397 PLN02397
aspartate transaminase
 32-430 0e+00

aspartate transaminase


:

Pssm-ID: 215222  Cd Length: 423  Bit Score: 725.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    32 WWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAE 111
Cdd:PLN02397  23 RFEHVEPAPPDPILGVTEAFLADPSPVKLNLGVGAYRTEEGKPVVLNVVRKAEQRLLAGSRNKEYLPIEGLAEFNKLSAK 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   112 LALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRdVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDF 191
Cdd:PLN02397 103 LAYGADSPAIKENRVATVQCLSGTGSLRLGAEFLARFYPGST-IYIPNPTWGNHHNIFRDAGVPVRTYRYYDPKTRGLDF 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   192 SGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINV 271
Cdd:PLN02397 182 DGLLEDLKAAPDGSFVLLHACAHNPTGVDPTPEQWEQISDLIKSKNHLPFFDSAYQGFASGDLDADAQSVRMFVEDGHEI 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   272 CLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRI 351
Cdd:PLN02397 262 LVAQSYAKNMGLYGERVGALSVVCKSADVAVRVKSQLKLIARPMYSNPPIHGASIVATILGDPELFSEWTKELKGMADRI 341

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754036   352 ISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK 430
Cdd:PLN02397 342 ISMRQKLYDALEARGSPGDWSHITKQIGMFSFTGLNKEQVDRMTKEYHIYMTRDGRISMAGLSSKNVPYLADAIHAVVT 420
 
Name Accession Description Interval E-value
PLN02397 PLN02397
aspartate transaminase
 32-430 0e+00

aspartate transaminase


Pssm-ID: 215222  Cd Length: 423  Bit Score: 725.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    32 WWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAE 111
Cdd:PLN02397  23 RFEHVEPAPPDPILGVTEAFLADPSPVKLNLGVGAYRTEEGKPVVLNVVRKAEQRLLAGSRNKEYLPIEGLAEFNKLSAK 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   112 LALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRdVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDF 191
Cdd:PLN02397 103 LAYGADSPAIKENRVATVQCLSGTGSLRLGAEFLARFYPGST-IYIPNPTWGNHHNIFRDAGVPVRTYRYYDPKTRGLDF 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   192 SGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINV 271
Cdd:PLN02397 182 DGLLEDLKAAPDGSFVLLHACAHNPTGVDPTPEQWEQISDLIKSKNHLPFFDSAYQGFASGDLDADAQSVRMFVEDGHEI 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   272 CLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRI 351
Cdd:PLN02397 262 LVAQSYAKNMGLYGERVGALSVVCKSADVAVRVKSQLKLIARPMYSNPPIHGASIVATILGDPELFSEWTKELKGMADRI 341

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754036   352 ISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK 430
Cdd:PLN02397 342 ISMRQKLYDALEARGSPGDWSHITKQIGMFSFTGLNKEQVDRMTKEYHIYMTRDGRISMAGLSSKNVPYLADAIHAVVT 420
TyrB COG1448
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic ...
 35-429 0e+00

Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 441057  Cd Length: 396  Bit Score: 590.15  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   35 HVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELAL 114
Cdd:COG1448   4 HLEAAPGDPILGLMEAFRADPRPNKVNLGVGVYKDEQGRTPVLRAVKAAEQRLLETETTKSYLPIEGDAAFNDAVQKLLF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  115 GENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRdVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGA 194
Cdd:COG1448  84 GADSPAVAAGRVATVQTPGGTGALRVGADFLKRAFPDAT-VWVSDPTWPNHRAIFEAAGLEVKTYPYYDAETGGVDFDGM 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  195 LEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFasGDG-DKDAWAVRHFIEQGINVCL 273
Cdd:COG1448 163 LADLKQLPAGDVVLLHGCCHNPTGADLTPEQWQEVAELLKERGLIPFLDIAYQGF--GDGlEEDAAGLRLFAEAGPEFLV 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  274 CQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIIS 353
Cdd:COG1448 241 ASSFSKNFGLYRERVGALSVVAADAEEADRVLSQLKALIRTNYSNPPDHGAAIVATILNDPELRALWEAELAEMRERIKA 320

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754036  354 MRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVT 429
Cdd:COG1448 321 MRQQLVDALRAKGPSRDFSFIARQRGMFSYLGLSPEQVDRLREEFGIYMVGSGRINVAGLNESNIDYVAEAIAAVL 396
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
57-425 3.27e-105

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 315.40  E-value: 3.27e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036     57 SKKMNLGVGAYRDDngkpyVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENneVLKSGRFVTVQTISGTG 136
Cdd:pfam00155   1 TDKINLGSNEYLGD-----TLPAVAKAEKDALAGGTRNLYGPTDGHPELREALAKFLGRSP--VLKLDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    137 ALRVGASFLqrFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPeqsVLLLHACAHNP 216
Cdd:pfam00155  74 ANIEALIFL--LANPGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKP---KVVLHTSPHNP 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    217 TGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASgdGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCk 296
Cdd:pfam00155 149 TGTVATLEELEKLLDLAKEHNILLLVDEAYAGFVF--GSPDAVATRALLAEGPNLLVVGSFSKAFGLAGWRVGYILGNA- 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    297 daeeakRVESQLKILIRPLYSnpPLNGARIAATILTSPDLRKQWLQEvkgMADRIISMRTQLVSNLKKEGsshnWQHITD 376
Cdd:pfam00155 226 ------AVISQLRKLARPFYS--STHLQAAAAAALSDPLLVASELEE---MRQRIKERRDYLRDGLQAAG----LSVLPS 290

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6754036    377 QIGMFCFTGLKPEQV----ERLTKEFSVYMTK--------DGRISVAGVTSGNVGYLAHAI 425
Cdd:pfam00155 291 QAGFFLLTGLDPETAkelaQVLLEEVGVYVTPgsspgvpgWLRITVAGGTEEELEELLEAI 351
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 60-427 3.27e-49

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 170.60  E-value: 3.27e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   60 MNLGVGAYRDDngkpyVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRfvTVQTISGTGALR 139
Cdd:cd00609   1 IDLSIGEPDFP-----PPPEVLEALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPEE--IVVTNGAQEALS 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  140 VGASFlqrFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKtcGFDFSGALEDISKIPEQSVLLLHACaHNPTGV 219
Cdd:cd00609  74 LLLRA---LLNPGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEEG--GFLLDLELLEAAKTPKTKLLYLNNP-NNPTGA 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  220 DPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAwavRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVckdae 299
Cdd:cd00609 148 VLSEEELEELAELAKKHGILIISDEAYAELVYDGEPPPA---LALLDAYERVIVLRSFSKTFGLPGLRIGYLIAP----- 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  300 eAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDlrkqwlQEVKGMADRIISMRTQLVSNLKKEGSSHNwqhITDQIG 379
Cdd:cd00609 220 -PEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGE------EHLEELRERYRRRRDALLEALKELGPLVV---VKPSGG 289

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754036  380 MFCFTGLKP----EQVERLTKEFSVYMTKDG----------RISVAGVTSGNVgYLAHAIHQ 427
Cdd:cd00609 290 FFLWLDLPEgddeEFLERLLLEAGVVVRPGSafgeggegfvRLSFATPEEELE-EALERLAE 350
 
Name Accession Description Interval E-value
PLN02397 PLN02397
aspartate transaminase
 32-430 0e+00

aspartate transaminase


Pssm-ID: 215222  Cd Length: 423  Bit Score: 725.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    32 WWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAE 111
Cdd:PLN02397  23 RFEHVEPAPPDPILGVTEAFLADPSPVKLNLGVGAYRTEEGKPVVLNVVRKAEQRLLAGSRNKEYLPIEGLAEFNKLSAK 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   112 LALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRdVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDF 191
Cdd:PLN02397 103 LAYGADSPAIKENRVATVQCLSGTGSLRLGAEFLARFYPGST-IYIPNPTWGNHHNIFRDAGVPVRTYRYYDPKTRGLDF 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   192 SGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINV 271
Cdd:PLN02397 182 DGLLEDLKAAPDGSFVLLHACAHNPTGVDPTPEQWEQISDLIKSKNHLPFFDSAYQGFASGDLDADAQSVRMFVEDGHEI 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   272 CLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRI 351
Cdd:PLN02397 262 LVAQSYAKNMGLYGERVGALSVVCKSADVAVRVKSQLKLIARPMYSNPPIHGASIVATILGDPELFSEWTKELKGMADRI 341

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754036   352 ISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK 430
Cdd:PLN02397 342 ISMRQKLYDALEARGSPGDWSHITKQIGMFSFTGLNKEQVDRMTKEYHIYMTRDGRISMAGLSSKNVPYLADAIHAVVT 420
PTZ00376 PTZ00376
aspartate aminotransferase; Provisional
 32-430 0e+00

aspartate aminotransferase; Provisional


Pssm-ID: 240390  Cd Length: 404  Bit Score: 670.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    32 WWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAE 111
Cdd:PTZ00376   4 LFSQVPLGPPDPILGLAAAFKADPSPSKVNLGIGAYRDENGKPYVLESVRKAEKIIAEKNLDKEYLPIEGLQSFIEAAQK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   112 LALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDF 191
Cdd:PTZ00376  84 LLFGEASYALAEKRIATVQALSGTGALRLGFEFLKRFLPAGTTVYVSNPTWPNHVNIFKSAGLNVKEYRYYDPKTKGLDF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   192 SGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINV 271
Cdd:PTZ00376 164 DGMLEDLRTAPNGSVVLLHACAHNPTGVDPTEEQWKEIADVMKRKNLIPFFDMAYQGFASGDLDKDAYAIRLFAERGVEF 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   272 CLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRI 351
Cdd:PTZ00376 244 LVAQSFSKNMGLYGERIGALHIVCANKEEAANVLSQLKLIIRPMYSSPPIHGARIADRILSDPELRAEWLSELKEMSGRI 323

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754036   352 ISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK 430
Cdd:PTZ00376 324 QNMRQLLYDELKALGSPGDWEHIINQIGMFSFTGLTKEQVERLIEKYHIYLLDNGRISVAGLTSKNVDYVAEAIHDVVR 402
TyrB COG1448
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic ...
 35-429 0e+00

Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 441057  Cd Length: 396  Bit Score: 590.15  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   35 HVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELAL 114
Cdd:COG1448   4 HLEAAPGDPILGLMEAFRADPRPNKVNLGVGVYKDEQGRTPVLRAVKAAEQRLLETETTKSYLPIEGDAAFNDAVQKLLF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  115 GENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRdVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGA 194
Cdd:COG1448  84 GADSPAVAAGRVATVQTPGGTGALRVGADFLKRAFPDAT-VWVSDPTWPNHRAIFEAAGLEVKTYPYYDAETGGVDFDGM 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  195 LEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFasGDG-DKDAWAVRHFIEQGINVCL 273
Cdd:COG1448 163 LADLKQLPAGDVVLLHGCCHNPTGADLTPEQWQEVAELLKERGLIPFLDIAYQGF--GDGlEEDAAGLRLFAEAGPEFLV 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  274 CQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIIS 353
Cdd:COG1448 241 ASSFSKNFGLYRERVGALSVVAADAEEADRVLSQLKALIRTNYSNPPDHGAAIVATILNDPELRALWEAELAEMRERIKA 320

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754036  354 MRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVT 429
Cdd:COG1448 321 MRQQLVDALRAKGPSRDFSFIARQRGMFSYLGLSPEQVDRLREEFGIYMVGSGRINVAGLNESNIDYVAEAIAAVL 396
PRK09257 PRK09257
aromatic amino acid transaminase;
35-428 0e+00

aromatic amino acid transaminase;


Pssm-ID: 181731  Cd Length: 396  Bit Score: 582.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    35 HVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELAL 114
Cdd:PRK09257   4 HLEAAPADPILGLMEAFRADPRPDKVNLGVGVYKDEQGRTPVLRAVKKAEARLLETETTKNYLPIEGLAAYRQAVQELLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   115 GENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKfSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGA 194
Cdd:PRK09257  84 GADSPALAAGRVATVQTPGGTGALRVGADFLKRAFP-DAKVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAATKGLDFDAM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   195 LEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFasGDG-DKDAWAVRHFIEQGINVCL 273
Cdd:PRK09257 163 LADLSQAPAGDVVLLHGCCHNPTGADLTPEQWDELAELLKERGLIPFLDIAYQGF--GDGlEEDAYGLRAFAAAGLELLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   274 CQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIIS 353
Cdd:PRK09257 241 ASSFSKNFGLYGERVGALSVVAEDAEEADRVLSQLKATIRTNYSNPPAHGAAIVATILNDPELRAEWEAELEEMRERIKA 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754036   354 MRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQV 428
Cdd:PRK09257 321 MRQLLVEALKAKGPSRDFDFIARQRGMFSYSGLTPEQVDRLREEFGVYAVGSGRINVAGLNESNIDYVAEAIAAV 395
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
57-425 3.27e-105

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 315.40  E-value: 3.27e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036     57 SKKMNLGVGAYRDDngkpyVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENneVLKSGRFVTVQTISGTG 136
Cdd:pfam00155   1 TDKINLGSNEYLGD-----TLPAVAKAEKDALAGGTRNLYGPTDGHPELREALAKFLGRSP--VLKLDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    137 ALRVGASFLqrFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPeqsVLLLHACAHNP 216
Cdd:pfam00155  74 ANIEALIFL--LANPGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKP---KVVLHTSPHNP 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    217 TGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASgdGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCk 296
Cdd:pfam00155 149 TGTVATLEELEKLLDLAKEHNILLLVDEAYAGFVF--GSPDAVATRALLAEGPNLLVVGSFSKAFGLAGWRVGYILGNA- 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    297 daeeakRVESQLKILIRPLYSnpPLNGARIAATILTSPDLRKQWLQEvkgMADRIISMRTQLVSNLKKEGsshnWQHITD 376
Cdd:pfam00155 226 ------AVISQLRKLARPFYS--STHLQAAAAAALSDPLLVASELEE---MRQRIKERRDYLRDGLQAAG----LSVLPS 290

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6754036    377 QIGMFCFTGLKPEQV----ERLTKEFSVYMTK--------DGRISVAGVTSGNVGYLAHAI 425
Cdd:pfam00155 291 QAGFFLLTGLDPETAkelaQVLLEEVGVYVTPgsspgvpgWLRITVAGGTEEELEELLEAI 351
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 60-427 3.27e-49

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 170.60  E-value: 3.27e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   60 MNLGVGAYRDDngkpyVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRfvTVQTISGTGALR 139
Cdd:cd00609   1 IDLSIGEPDFP-----PPPEVLEALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPEE--IVVTNGAQEALS 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  140 VGASFlqrFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKtcGFDFSGALEDISKIPEQSVLLLHACaHNPTGV 219
Cdd:cd00609  74 LLLRA---LLNPGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEEG--GFLLDLELLEAAKTPKTKLLYLNNP-NNPTGA 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  220 DPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAwavRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVckdae 299
Cdd:cd00609 148 VLSEEELEELAELAKKHGILIISDEAYAELVYDGEPPPA---LALLDAYERVIVLRSFSKTFGLPGLRIGYLIAP----- 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  300 eAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDlrkqwlQEVKGMADRIISMRTQLVSNLKKEGSSHNwqhITDQIG 379
Cdd:cd00609 220 -PEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGE------EHLEELRERYRRRRDALLEALKELGPLVV---VKPSGG 289

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754036  380 MFCFTGLKP----EQVERLTKEFSVYMTKDG----------RISVAGVTSGNVgYLAHAIHQ 427
Cdd:cd00609 290 FFLWLDLPEgddeEFLERLLLEAGVVVRPGSafgeggegfvRLSFATPEEELE-EALERLAE 350
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 119-293 3.20e-08

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 52.77  E-value: 3.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  119 EVLKSGRFVTVQTISGTGALRVGASFLqrfFKFSRDVFLPKPSWGNHTPIFRD-AGMQLQGYRYyDPKTCGFDFSGALED 197
Cdd:cd01494  11 RLLQPGNDKAVFVPSGTGANEAALLAL---LGPGDEVIVDANGHGSRYWVAAElAGAKPVPVPV-DDAGYGGLDVAILEE 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  198 ISKIPEQSVLLLHACAHNPTGVDPRpeqwKEIASVVKKKNLFAFFDMAYQGFASGdgdkdaWAVRHFIEQGINVCLcQSY 277
Cdd:cd01494  87 LKAKPNVALIVITPNTTSGGVLVPL----KEIRKIAKEYGILLLVDAASAGGASP------APGVLIPEGGADVVT-FSL 155

                       170
                ....*....|....*.
gi 6754036  278 AKNMGlyGERVGAFTV 293
Cdd:cd01494 156 HKNLG--GEGGGVVIV 169
PRK08637 PRK08637
hypothetical protein; Provisional
 57-350 1.29e-07

hypothetical protein; Provisional


Pssm-ID: 181512  Cd Length: 388  Bit Score: 53.42  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    57 SKKMNLGVGAYRDDNGKPYvLPSVRKAEAQIAAKNLdKEYLPIGGLAEFCKASAELALGENnEVLKSgrfvtvQTISG-- 134
Cdd:PRK08637   3 ATKYNATIGMATEKGGPMY-LSSLQDLLNDLTPDEI-FPYAPPQGIPELRDLWQEKMLREN-PSLSG------KKMSLpi 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   135 -TGALRVGASFLQRFFKFSRD-VFLPKPSWGNHTPIFRDA-GMQLQGYRYYDpKTCGFDFSGALE--DISKIPEQSVLLL 209
Cdd:PRK08637  74 vTNALTHGLSLVADLFVDQGDtVLLPDHNWGNYKLTFNTRrGAEIVTYPIFD-EDGGFDTDALKEalQAAYNKGKVIVIL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   210 HAcAHNPTGVDPRPEQWKEIASVVKK-----KNLFAFFDMAYQGFASGDGDKdawavrhfieQGINVCLCQSY------- 277
Cdd:PRK08637 153 NF-PNNPTGYTPTEKEATAIVEAIKEladagTKVVAVVDDAYFGLFYEDSYK----------ESLFAALANLHsnilavk 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   278 ----AKNMGLYGERVGAFTVVCK--DAEEAKRV-ESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADR 350
Cdd:PRK08637 222 ldgaTKEEFVWGFRVGFITFGTKagSSQTVKEAlEKKVKGLIRSNISNGPHPSQSAVLRALNSPEFDKEKQEKFQILKER 301
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 155-403 4.26e-06

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 48.59  E-value: 4.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  155 VFLPKPSWGNHTPIFRDAGMQLqgyRYY--DPKTcgfDFSGALEDI-SKIPEQSVLLLHACAHNPTGVDPRPEQWKEIAS 231
Cdd:COG0436 117 VLVPDPGYPSYRAAVRLAGGKP---VPVplDEEN---GFLPDPEALeAAITPRTKAIVLNSPNNPTGAVYSREELEALAE 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  232 VVKKKNLFAFFDMAYQGFASgDGDK--DAWAVRHFIEQGInvcLCQSYAKNMGLYGERVGaFTVVCKD-AEEAKRVESQl 308
Cdd:COG0436 191 LAREHDLLVISDEIYEELVY-DGAEhvSILSLPGLKDRTI---VINSFSKSYAMTGWRIG-YAVGPPElIAALLKLQSN- 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036  309 kilirpLYSNPPLNGARIAATILTSPDlrkqwlQEVKGMADRIISMRTQLVSNLKKEGsshnWQHITDQIGMFCFTGLKP 388
Cdd:COG0436 265 ------LTSCAPTPAQYAAAAALEGPQ------DYVEEMRAEYRRRRDLLVEGLNEIG----LSVVKPEGAFYLFADVPE 328

                       250       260
                ....*....|....*....|.
gi 6754036  389 ------EQVERLTKEFSVYMT 403
Cdd:COG0436 329 lgldseEFAERLLEEAGVAVV 349
PRK06836 PRK06836
pyridoxal phosphate-dependent aminotransferase;
214-334 1.89e-04

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180720  Cd Length: 394  Bit Score: 43.26  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   214 HNPTGVDPRPEQWKEIASVVKKKN------LFAFFDMAYQGFASgDGDKDAWAVRHFIeqgiNVCLCQSYAKNMGLYGER 287
Cdd:PRK06836 178 NNPTGVVYSEETLKALAALLEEKSkeygrpIYLISDEPYREIVY-DGAEVPYIFKYYD----NSIVVYSFSKSLSLPGER 252

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 6754036   288 VGaFTVVCKDAEEAKRVESQLKILIRPL-YSNPPLNGARIAATILTSP 334
Cdd:PRK06836 253 IG-YIAVNPEMEDADDLVAALVFANRILgFVNAPALMQRVVAKCLDAT 299
PRK07683 PRK07683
aminotransferase A; Validated
 154-246 9.42e-04

aminotransferase A; Validated


Pssm-ID: 236075  Cd Length: 387  Bit Score: 41.25  E-value: 9.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   154 DVFLPKPSWGNHTPIFRDAGMQLQgyrYYDPKTCGFDFSG-ALEDIskIPEQSVLLLHACAHNPTGVDPRPEQWKEIASV 232
Cdd:PRK07683 115 EVILPAPIYPGYEPIIRLCGAKPV---FIDTRSTGFRLTAeALENA--ITEKTRCVVLPYPSNPTGVTLSKEELQDIADV 189

                         90
                 ....*....|....
gi 6754036   233 VKKKNLFAFFDMAY 246
Cdd:PRK07683 190 LKDKNIFVLSDEIY 203
PRK07309 PRK07309
pyridoxal phosphate-dependent aminotransferase;
84-246 1.72e-03

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235985  Cd Length: 391  Bit Score: 40.48  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036    84 EAQIAAKNLDKE-YLPIGGLAEFCKASAELALGENNEVLKSGRFVTVqTISGTGALrvgASFLQRFFKFSRDVFLPKPSW 162
Cdd:PRK07309  50 EAAKRAIDANQShYTGMAGLLELRQAAADFVKEKYNLDYAPENEILV-TIGATEAL---SASLTAILEPGDKVLLPAPAY 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   163 GNHTPIfrdagMQLQGYRYYDPKTCGFDFSGALEDISK-IPEQ-----SVLLLHACahNPTGVDPRPEQWKEIASVVKKK 236
Cdd:PRK07309 126 PGYEPI-----VNLVGAEIVEIDTTENDFVLTPEMLEKaILEQgdklkAVILNYPA--NPTGVTYSREQIKALADVLKKY 198

                        170
                 ....*....|
gi 6754036   237 NLFAFFDMAY 246
Cdd:PRK07309 199 DIFVISDEVY 208
PRK06348 PRK06348
pyridoxal phosphate-dependent aminotransferase;
215-289 2.42e-03

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180537  Cd Length: 384  Bit Score: 40.09  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754036   215 NPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGF---------ASGDGDKDawavrHFIEQGinvclcqSYAKNMGLYG 285
Cdd:PRK06348 173 NPTGAVFSKETLEEIAKIAIEYDLFIISDEVYDGFsfyedfvpmATLAGMPE-----RTITFG-------SFSKDFAMTG 240


                 ....
gi 6754036   286 ERVG 289
Cdd:PRK06348 241 WRIG 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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