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mio missing oocyte [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33399, updated on 4-Jan-2025

Summary

Official Symbol
mioprovided by FlyBase
Official Full Name
missing oocyteprovided by FlyBase
Primary source
FLYBASE:FBgn0031399
Locus tag
Dmel_CG7074
See related
AllianceGenome:FB:FBgn0031399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15384; CG7074; Dmel\CG7074; FBtr0077835; GATOR2; Mio; Sea4; SEA4
Summary
Involved in several processes, including oogenesis; positive regulation of TORC1 signaling; and regulation of autophagy. Located in autolysosome and female germ cell nucleus. Part of GATOR2 complex. Is expressed in adult head; germarium region 2a; oocyte; and ovary. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See mio in Genome Data Viewer
Location:
22D4-22D4; 2-5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2217290..2220625)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2217290..2220625)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene daedalus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene papi Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of GATOR2 complex PubMed 
part_of Seh1-associated complex PubMed 
part_of Seh1-associated complex PubMed 
located_in autolysosome PubMed 
is_active_in cytoplasm  
located_in female germ cell nucleus PubMed 
located_in lysosome PubMed 
located_in nucleus PubMed 
part_of protein-containing complex PubMed 

General protein information

Preferred Names
missing oocyte
Names
CG7074-PA
mio-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2217290..2220625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134812.3 → NP_608656.1  missing oocyte [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608656.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RC2, Q9VQ89
    Related
    FBpp0077507
    Conserved Domains (4) summary
    COG2319
    Location:65 → 266
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:8 → 44
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:60 → 266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl24077
    Location:741 → 852
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type
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