U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    PolE1 DNA polymerase epsilon subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42758, updated on 4-Jan-2025

    Summary

    Official Symbol
    PolE1provided by FlyBase
    Official Full Name
    DNA polymerase epsilon subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0264326
    Locus tag
    Dmel_CG6768
    See related
    AllianceGenome:FB:FBgn0264326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6768; BAB17608; CG6768; Dmel\CG6768; DNA pol epsilon; DNApol-epsilon; DNApol-epsilon255; dpolepsilon; dpolepsilon255; dpolepsilonp255; l(3)pl10; l(3)pl10R; pl[10]; pol-epsilon; Polepsilon; Polepsilon255; Polepsilon255KDa
    Summary
    Enables 3'-5'-DNA exonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA replication proofreading; DNA synthesis involved in DNA replication; and endomitotic cell cycle. Located in nucleus. Part of epsilon DNA polymerase complex. Is expressed in embryonic/larval Malpighian tubule; embryonic/larval salivary gland; gamete; imaginal disc; and larval brain. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); endometrial cancer (multiple); lung cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PolE1 in Genome Data Viewer
    Location:
    94E13-94E13; 3-78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23348128..23355163)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19173850..19180885)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene big bubble 8 Neighboring gene pointed Neighboring gene long non-coding RNA:CR46090 Neighboring gene ATP synthase, coupling factor 6 Neighboring gene Secretory 13

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity PubMed 
    enables DNA binding  
    enables DNA binding  
    enables DNA-directed DNA polymerase activity  
    enables DNA-directed DNA polymerase activity PubMed 
    enables DNA-directed DNA polymerase activity  
    enables nucleotide binding  
    enables protein binding PubMed 
    enables single-stranded DNA 3'-5' DNA exonuclease activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in DNA repair  
    involved_in DNA repair PubMed 
    involved_in DNA replication  
    involved_in DNA replication proofreading  
    involved_in DNA replication proofreading PubMed 
    involved_in DNA synthesis involved in DNA replication PubMed 
    involved_in DNA-templated DNA replication PubMed 
    involved_in base-excision repair, gap-filling  
    involved_in endomitotic cell cycle PubMed 
    involved_in leading strand elongation  
    involved_in mitotic cell cycle  
    involved_in mitotic cell cycle PubMed 
    involved_in nucleotide-excision repair, DNA gap filling  
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex  
    part_of epsilon DNA polymerase complex  
    part_of epsilon DNA polymerase complex PubMed 
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    DNA polymerase epsilon subunit 1
    Names
    CG6768-PA
    DNA polymerase epsilon
    DNA polymerase epsilon 255kD subunit
    DNApol-epsilon
    DNApolymarase E
    PolE1-PA
    lethal (3) pl10
    pol.epsilon catalytic subunit
    NP_524462.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23348128..23355163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079738.3NP_524462.2  DNA polymerase epsilon subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524462.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R46, Q9VCN1
      UniProtKB/TrEMBL
      G3M399
      Related
      FBpp0083800
      Conserved Domains (3) summary
      cd05779
      Location:266469
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      cd05535
      Location:5291154
      POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
      pfam08490
      Location:15291930
      DUF1744; Domain of unknown function (DUF1744)
    External link. Please review our privacy policy.