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bet-1 Bromodomain-containing protein bet-1 [ Caenorhabditis elegans ]

Gene ID: 172054, updated on 4-Jan-2025

Summary

Official Symbol
bet-1
Official Full Name
Bromodomain-containing protein bet-1
Primary source
WormBase:WBGene00022473
Locus tag
CELE_Y119C1B.8
See related
AllianceGenome:WB:WBGene00022473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables SUMO binding activity and lysine-acetylated histone binding activity. Involved in several processes, including multicellular organismal locomotion; muscle cell cellular homeostasis; and regulation of DNA-templated transcription. Located in chromosome; metaphase plate; and nucleus. Is expressed in several structures, including body wall musculature; hypodermis; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Cornelia de Lange syndrome 6; idiopathic pulmonary fibrosis; lymphoma (multiple); male infertility (multiple); and photosensitivity disease. Orthologous to several human genes including BRD2 (bromodomain containing 2) and BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See bet-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
14
Sequence:
Chromosome: I; NC_003279.8 (4525961..4534805, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene Conserved plasma membrane protein Neighboring gene Ig-like domain-containing protein Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SUMO binding PubMed 
enables histone binding  
enables lysine-acetylated histone binding  
enables lysine-acetylated histone binding PubMed 
enables lysine-acetylated histone binding PubMed 
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in cell fate specification PubMed 
involved_in chromatin remodeling  
involved_in multicellular organismal locomotion PubMed 
involved_in multicellular organismal locomotion PubMed 
involved_in muscle cell cellular homeostasis PubMed 
involved_in muscle cell cellular homeostasis PubMed 
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in negative regulation of cell fate specification PubMed 
involved_in neuroblast fate specification PubMed 
involved_in protein localization to chromatin PubMed 
involved_in regulation of DNA-templated transcription  
involved_in regulation of protein stability PubMed 
involved_in regulation of protein stability PubMed 
involved_in regulation of transcription by RNA polymerase II PubMed 
involved_in regulation of vulval development PubMed 
Component Evidence Code Pubs
located_in chromatin  
located_in chromosome PubMed 
located_in chromosome  
located_in metaphase plate PubMed 
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
Bromodomain-containing protein bet-1
NP_001364495.1
  • Confirmed by transcript evidence
NP_001366623.1
  • Confirmed by transcript evidence
NP_001366624.1
  • Confirmed by transcript evidence
NP_001366625.1
  • Confirmed by transcript evidence
NP_001366626.1
  • Confirmed by transcript evidence
NP_001367704.1
  • Confirmed by transcript evidence
NP_001367705.1
  • Confirmed by transcript evidence
NP_001379011.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4525961..4534805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377574.2NP_001364495.1  Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MQE5
    Conserved Domains (6) summary
    cd05497
    Location:39145
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:262363
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PLN02967
    Location:95240
    PLN02967; kinase
    pfam15791
    Location:684730
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam17035
    Location:526592
    BET; Bromodomain extra-terminal - transcription regulation
    cl21508
    Location:371416
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
  2. NM_001379848.2NP_001366626.1  Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MPT0
    Conserved Domains (6) summary
    cd05497
    Location:39145
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:262363
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PLN02967
    Location:95240
    PLN02967; kinase
    pfam15791
    Location:684730
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam17035
    Location:526592
    BET; Bromodomain extra-terminal - transcription regulation
    cl21508
    Location:371416
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
  3. NM_001379845.1NP_001366623.1  Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MM65
    Conserved Domains (6) summary
    cd05497
    Location:39145
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:262363
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PLN02967
    Location:95240
    PLN02967; kinase
    pfam15791
    Location:682728
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam17035
    Location:526592
    BET; Bromodomain extra-terminal - transcription regulation
    cl21508
    Location:371416
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
  4. NM_001379837.2NP_001367704.1  Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (6) summary
    cd05497
    Location:39145
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:262363
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PLN02967
    Location:95240
    PLN02967; kinase
    pfam15791
    Location:680726
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam17035
    Location:526592
    BET; Bromodomain extra-terminal - transcription regulation
    cl21508
    Location:371416
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
  5. NM_001379846.3NP_001366624.1  Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MN31
    Conserved Domains (6) summary
    cd05497
    Location:39145
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:262363
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PLN02967
    Location:95240
    PLN02967; kinase
    pfam15791
    Location:682728
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam17035
    Location:526592
    BET; Bromodomain extra-terminal - transcription regulation
    cl21508
    Location:371416
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
  6. NM_001379840.2NP_001367705.1  Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KZI7, Q95Y80
    Conserved Domains (6) summary
    cd05497
    Location:39145
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:262363
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PLN02967
    Location:95240
    PLN02967; kinase
    pfam15791
    Location:680726
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam17035
    Location:526592
    BET; Bromodomain extra-terminal - transcription regulation
    cl21508
    Location:371416
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
  7. NM_001392164.1NP_001379011.1  Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MMD4
    Conserved Domains (6) summary
    cd05497
    Location:39145
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:262363
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PLN02967
    Location:95240
    PLN02967; kinase
    pfam15791
    Location:682728
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam17035
    Location:526592
    BET; Bromodomain extra-terminal - transcription regulation
    cl21508
    Location:371416
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
  8. NM_001379843.2NP_001366625.1  Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MMP9
    Conserved Domains (6) summary
    cd05497
    Location:39145
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:262363
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PLN02967
    Location:95240
    PLN02967; kinase
    pfam15791
    Location:682728
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    pfam17035
    Location:526592
    BET; Bromodomain extra-terminal - transcription regulation
    cl21508
    Location:371416
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
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