ubc-9 SUMO-conjugating enzyme UBC9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubc-9
Official Full Name: SUMO-conjugating enzyme UBC9
Primary source: WormBase:WBGene00006706
Locus tag: CELE_F29B9.6
See related: AllianceGenome:WB:WBGene00006706
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; SAM domain binding activity; and SUMO conjugating enzyme activity. Involved in several processes, including chordate pharyngeal muscle development; negative regulation of transcription by RNA polymerase II; and protein sumoylation. Predicted to be located in nuclear envelope. Predicted to be active in nucleus. Is expressed in several structures, including body wall musculature; coelomocyte; germ line; pharynx; and tail. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ubc-9 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (4651044..4652447)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TBX-2 and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 function requires sumoylation.
Title: The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F29B9.6 (e-PCR)
- UniSTS:316673

F29B9.5 (e-PCR)
- UniSTS:322092

F29B9.7 (e-PCR)
- UniSTS:320952

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables SAM domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SUMO conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chordate pharyngeal muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification by small protein conjugation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SUMO-conjugating enzyme UBC9

NP_001023158.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4651044..4652447

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027987.7 → NP_001023158.1 SUMO-conjugating enzyme UBC9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023158.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95017, Q9GYI5

Conserved Domains (2) summary

COG5078
Location:1 → 156

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

pfam00179
Location:8 → 149

UQ_con; Ubiquitin-conjugating enzyme