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ALB4 OxaA/YidC-like membrane insertion protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839065, updated on 18-Sep-2024

Summary

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Official Symbol
ALB4
Official Full Name
OxaA/YidC-like membrane insertion protein
Primary source
TAIR:AT1G24490
Locus tag
AT1G24490
See related
Araport:AT1G24490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ALBINA 4; ARABIDOPSIS THALIANA ENVELOPE MEMBRANE INTEGRASE; ARTEMIS; F21J9.16
Summary
Homologue of the Alb3/Oxa1/YidC family. ALB4 is almost identical to the Alb3/Oxa1/YidC domain of the previously described 110 kDa inner envelope protein ARTEMIS. However, ALB4 is expressed as a separate 55 kDa protein and is located in the thylakoid membrane of chloroplasts. Analysis of a T-DNA insertion line with a reduced level of Alb4 revealed chloroplasts with an altered ultrastructure. Mutant plastids are larger, more spherical in appearance and the grana stacks within the mutant lines are less appressed than in the wild-type chloroplasts. ALB4 is required for proper chloroplast biogenesis.
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Genomic context

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See ALB4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (8682195..8685271)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene beta-ketoacyl reductase 2 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ER protein carbohydrate-binding protein Neighboring gene TCP-1/cpn60 chaperonin family protein Neighboring gene homolog of Brassica campestris pollen protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A second thylakoid membrane-localized Alb3/OxaI/YidC homologue is involved in proper chloroplast biogenesis in Arabidopsis thaliana. Gerdes L, et al. J Biol Chem, 2006 Jun 16. PMID 16595657
  2. Suppressors of the Chloroplast Protein Import Mutant tic40 Reveal a Genetic Link between Protein Import and Thylakoid Biogenesis. Bédard J, et al. Plant Cell, 2017 Jul. PMID 28684427, Free PMC Article
  3. Genetic and Physical Interaction Studies Reveal Functional Similarities between ALBINO3 and ALBINO4 in Arabidopsis. Trösch R, et al. Plant Physiol, 2015 Oct. PMID 26265777, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALB4 and STIC2 both participate in thylakoid protein targeting
    Title: Suppressors of the Chloroplast Protein Import Mutant tic40 Reveal a Genetic Link between Protein Import and Thylakoid Biogenesis.
  2. ALB4 optimizes the insertion of thylakoid proteins by participating in the ALB3-chloroplast signal recognition particle pathway.
    Title: Genetic and Physical Interaction Studies Reveal Functional Similarities between ALBINO3 and ALBINO4 in Arabidopsis.
  3. Alb3 has a role in insertion of a subset of the light-harvesting chlorophyll-binding proteins, while Alb4 is required for proper chloroplast biogenesis
    Title: A second thylakoid membrane-localized Alb3/OxaI/YidC homologue is involved in proper chloroplast biogenesis in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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General gene information

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NM_001160892.1
NM_102294.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables membrane insertase activity  
enables protein binding PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chloroplast organization PubMed 
acts_upstream_of_or_within protein localization to chloroplast PubMed 
Component Evidence Code Pubs
located_in chloroplast PubMed 
located_in chloroplast  
located_in chloroplast thylakoid membrane PubMed 
located_in thylakoid PubMed 

General protein information

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Preferred Names
OxaA/YidC-like membrane insertion protein
NP_001154364.1
  • ALBINA 4 (ALB4); CONTAINS InterPro DOMAIN/s: Membrane insertion protein, OxaA/YidC (InterPro:IPR001708), Membrane insertion protein, OxaA/YidC, core (InterPro:IPR020001); BEST Arabidopsis thaliana protein match is: 63 kDa inner membrane family protein (TAIR:AT2G28800.1); Has 8058 Blast hits to 8029 proteins in 2465 species: Archae - 0; Bacteria - 5573; Metazoa - 87; Fungi - 22; Plants - 115; Viruses - 0; Other Eukaryotes - 2261 (source: NCBI BLink).
NP_173858.5
  • ALBINA 4 (ALB4); CONTAINS InterPro DOMAIN/s: Membrane insertion protein, OxaA/YidC (InterPro:IPR001708), Membrane insertion protein, OxaA/YidC, core (InterPro:IPR020001); BEST Arabidopsis thaliana protein match is: 63 kDa inner membrane family protein (TAIR:AT2G28800.1); Has 8883 Blast hits to 8828 proteins in 2598 species: Archae - 0; Bacteria - 5941; Metazoa - 162; Fungi - 75; Plants - 144; Viruses - 0; Other Eukaryotes - 2561 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    8682195..8685271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102294.7 → NP_173858.5  OxaA/YidC-like membrane insertion protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173858.5

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1RPP7, Q9FYL3, Q9FYL4
    UniProtKB/TrEMBL
    A0A178W2M5
    Conserved Domains (2) summary
    PRK00247
    Location:123 → 480
    PRK00247; putative inner membrane protein translocase component YidC; Validated
    pfam02096
    Location:124 → 338
    60KD_IMP; 60Kd inner membrane protein

  2. NM_001160892.1 → NP_001154364.1  OxaA/YidC-like membrane insertion protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154364.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W2M5, F4I9A9
    Conserved Domains (1) summary
    pfam02096
    Location:112 → 301
    60KD_IMP; 60Kd inner membrane protein
Protein Accession Links
GenPept Link UniProtKB Link
Q9FYL3.3

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