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    RnrS Ribonucleoside diphosphate reductase small subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36280, updated on 4-Jan-2025

    Summary

    Official Symbol
    RnrSprovided by FlyBase
    Official Full Name
    Ribonucleoside diphosphate reductase small subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011704
    Locus tag
    Dmel_CG8975
    See related
    AllianceGenome:FB:FBgn0011704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.148; CG8975; Dmel\CG8975; DmRNR2; dRNR2; R2; RNR-S; rnr2; Rnr2; RNR2; rnrS; Rnrs; RnRs; RNrS; RNRS
    Summary
    Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be part of ribonucleoside-diphosphate reductase complex. Predicted to be active in cytosol. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; mitochondrial DNA depletion syndrome 8b; and pancreatic cancer. Orthologous to several human genes including RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See RnrS in Genome Data Viewer
    Location:
    48D5-48D5; 2-65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11983145..11985393, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7870650..7872898, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beta1,3-galactosyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene rhomboid-7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytosol  
    part_of ribonucleoside-diphosphate reductase complex  

    General protein information

    Preferred Names
    ribonucleoside diphosphate reductase small subunit
    Names
    CG8975-PA
    RnrS-PA
    ribonucleoside-diphosphate reductase small subunit
    ribonucleotide reductase
    ribonucleotide reductase small subunit
    NP_525111.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11983145..11985393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080372.4 → NP_525111.1  ribonucleoside diphosphate reductase small subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48592, Q9V640
      Related
      FBpp0087152
      Conserved Domains (1) summary
      cl00264
      Location:74 → 393
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
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