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    Ptprs protein tyrosine phosphatase receptor type S [ Mus musculus (house mouse) ]

    Gene ID: 19280, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptprsprovided by MGI
    Official Full Name
    protein tyrosine phosphatase receptor type Sprovided by MGI
    Primary source
    MGI:MGI:97815
    See related
    Ensembl:ENSMUSG00000013236 AllianceGenome:MGI:97815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTP; Ptpt9; PTP-NU3; PTPNU-3; R-PTP-S; PTPsigma; RPTPsigma; R-PTP-sigma
    Summary
    Enables chondroitin sulfate binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and regulation of postsynaptic density assembly. Acts upstream of or within central nervous system development and establishment of endothelial intestinal barrier. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 169.2), CNS E14 (RPKM 151.8) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Ptprs in Genome Data Viewer
    Location:
    17 D; 17 29.32 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56719426..56783480, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56412426..56476561, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3208 Neighboring gene STARR-positive B cell enhancer ABC_E3209 Neighboring gene ubiquitin-like, containing PHD and RING finger domains, 1 Neighboring gene STARR-positive B cell enhancer ABC_E141 Neighboring gene lysine (K)-specific demethylase 4B Neighboring gene STARR-positive B cell enhancer ABC_E8923 Neighboring gene predicted gene, 32715 Neighboring gene microRNA 6977 Neighboring gene STARR-positive B cell enhancer ABC_E5622 Neighboring gene STARR-positive B cell enhancer mm9_chr17:56601992-56602293 Neighboring gene predicted gene, 32822 Neighboring gene predicted gene 9258 Neighboring gene predicted gene, 33089 Neighboring gene predicted gene, 33211

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC90571

    Gene Ontology Provided by MGI

    Items 1 - 25 of 35
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebellum development PubMed 
    acts_upstream_of_or_within cerebral cortex development PubMed 
    involved_in chromatin remodeling  
    acts_upstream_of_or_within corpus callosum development PubMed 
    acts_upstream_of_or_within establishment of endothelial intestinal barrier PubMed 
    acts_upstream_of_or_within hippocampus development PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in negative regulation of axon extension PubMed 
    involved_in negative regulation of axon regeneration PubMed 
    involved_in negative regulation of collateral sprouting PubMed 
    involved_in negative regulation of dendritic spine development PubMed 
    involved_in negative regulation of interferon-alpha production  
    involved_in negative regulation of interferon-alpha production  
    involved_in negative regulation of interferon-beta production  
    involved_in negative regulation of interferon-beta production  
    involved_in negative regulation of neuron projection development PubMed 
    involved_in negative regulation of toll-like receptor 9 signaling pathway  
    involved_in negative regulation of toll-like receptor 9 signaling pathway  
    involved_in peptidyl-tyrosine dephosphorylation PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation PubMed 
    involved_in presynapse assembly  
    involved_in protein dephosphorylation  
    involved_in regulation of postsynaptic density assembly PubMed 
    involved_in regulation of postsynaptic density assembly PubMed 
    involved_in regulation of postsynaptic density assembly  
    involved_in signal transduction  
    acts_upstream_of_or_within spinal cord development PubMed 
    involved_in synapse organization PubMed 
    involved_in synapse organization PubMed 
    involved_in synaptic membrane adhesion  
    involved_in synaptic membrane adhesion  
    involved_in synaptic membrane adhesion  
    involved_in trans-synaptic signaling PubMed 
    involved_in trans-synaptic signaling PubMed 
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in axon  
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in growth cone  
    located_in perikaryon  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynaptic density membrane  
    located_in postsynaptic density membrane  
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane  
    located_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase S
    Names
    Receptor-type tyrosine-protein phosphatase sigma
    tissue-specific protein tyrosine phosphatase
    NP_001239382.1
    NP_001239384.1
    NP_001239385.1
    NP_035348.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252453.2NP_001239382.1  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239382.1

      Status: VALIDATED

      Source sequence(s)
      CT009637
      Consensus CDS
      CCDS57103.1
      UniProtKB/Swiss-Prot
      B0V2N1
      Conserved Domains (6) summary
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd14625
      Location:9231204
      R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
      cd14627
      Location:12061495
      R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
    2. NM_001252455.2NP_001239384.1  receptor-type tyrosine-protein phosphatase S isoform 3 precursor

      See identical proteins and their annotated locations for NP_001239384.1

      Status: VALIDATED

      Source sequence(s)
      CT009637
      Consensus CDS
      CCDS89125.1
      UniProtKB/Swiss-Prot
      B0V2N1
      Related
      ENSMUSP00000153134.2, ENSMUST00000223859.2
      Conserved Domains (6) summary
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:12281487
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:9671196
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    3. NM_001252456.2NP_001239385.1  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239385.1

      Status: VALIDATED

      Source sequence(s)
      CT009637
      Consensus CDS
      CCDS57103.1
      UniProtKB/Swiss-Prot
      B0V2N1
      Related
      ENSMUSP00000084038.4, ENSMUST00000086828.10
      Conserved Domains (6) summary
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd14625
      Location:9231204
      R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
      cd14627
      Location:12061495
      R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
    4. NM_011218.3NP_035348.2  receptor-type tyrosine-protein phosphatase S isoform 1 precursor

      See identical proteins and their annotated locations for NP_035348.2

      Status: VALIDATED

      Source sequence(s)
      CT009637
      Consensus CDS
      CCDS37664.1
      UniProtKB/Swiss-Prot
      B0V2N1, Q3TEC3, Q3TXC9, Q4JFC7, Q5XJV4, Q64503, Q64699, Q7TT17
      Related
      ENSMUSP00000064048.6, ENSMUST00000067538.6
      Conserved Domains (6) summary
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd14625
      Location:13291610
      R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
      cd14627
      Location:16121901
      R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56719426..56783480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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